Bancroftian filariasis: long-term effect of the DEC provocative day test on microfilaraemia
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Bancroftian filariasis: long-term effect of the DEC provocative day test on microfilaraemia. / Simonsen, Poul Erik; Meyrowitsch, Dan Wolf; Makunde, W.H.
I: Transactions of the Royal Society of Tropical Medicine and Hygiene, Bind 91, Nr. 3, 1997, s. 290-293.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Bancroftian filariasis: long-term effect of the DEC provocative day test on microfilaraemia
AU - Simonsen, Poul Erik
AU - Meyrowitsch, Dan Wolf
AU - Makunde, W.H.
N1 - Author Keywords: Author Keywords: filariasis; Wuchereria bancrofti; diagnosis; diethylcarbamazine; provocative day test
PY - 1997
Y1 - 1997
N2 - The diethylcarbamazine (DEC) provocative day test has been widely used for daytime diagnosis of Wuchereria bancrofti infections in areas where microfilariae exhibit nocturnal periodicity. Since DEC is also the primary drug for treatment of bancroftian filariasis, we examined the long term effect of the test on microfilaraemia in 2 groups of individuals receiving either 100 mg of DEC (n = 51) or placebo (n = 20). The low dose of DEC had a significant therapeutic effect. One year after treatment, the geometric mean intensity of microfilaraemia was reduced by 86·1%, and 10·6% of the individuals were amicrofilaraemic. No significant reduction of microfilaraemia was observed in the placebo group. The results imply that the DEC provocative day test should not be used as a diagnostic tool in follow-up studies on microfilaraemias.
AB - The diethylcarbamazine (DEC) provocative day test has been widely used for daytime diagnosis of Wuchereria bancrofti infections in areas where microfilariae exhibit nocturnal periodicity. Since DEC is also the primary drug for treatment of bancroftian filariasis, we examined the long term effect of the test on microfilaraemia in 2 groups of individuals receiving either 100 mg of DEC (n = 51) or placebo (n = 20). The low dose of DEC had a significant therapeutic effect. One year after treatment, the geometric mean intensity of microfilaraemia was reduced by 86·1%, and 10·6% of the individuals were amicrofilaraemic. No significant reduction of microfilaraemia was observed in the placebo group. The results imply that the DEC provocative day test should not be used as a diagnostic tool in follow-up studies on microfilaraemias.
U2 - 10.1016/S0035-9203(97)90079-1
DO - 10.1016/S0035-9203(97)90079-1
M3 - Journal article
VL - 91
SP - 290
EP - 293
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 3
ER -
ID: 218790