Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark
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Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark. / Bille, Camilla; Pedersen, Dorthe Almind; Andersen, Anne-Marie Nybo; Mansilla, Maria A; Murray, Jeff; Christensen, Kaare; Ballard, Johnathan L; Gorman, Elizabeth B; Cabrera, Robert M; Finnell, Richard H.
I: Pediatric Research, Bind 67, Nr. 3, 2010, s. 274-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark
AU - Bille, Camilla
AU - Pedersen, Dorthe Almind
AU - Andersen, Anne-Marie Nybo
AU - Mansilla, Maria A
AU - Murray, Jeff
AU - Christensen, Kaare
AU - Ballard, Johnathan L
AU - Gorman, Elizabeth B
AU - Cabrera, Robert M
AU - Finnell, Richard H
PY - 2010
Y1 - 2010
N2 - The objective of this study was to determine whether IgG and IgM autoantibodies to folate receptor alpha (FRalpha) in pregnant women are associated with an increased risk of oral cleft-affected offspring. A case-control study nested in the prospective Danish National Birth Cohort (100,418 pregnancies, enrolled during 1997-2003) was done. Hundred eighty-five children were born with an oral cleft. Maternal serum from their mothers (cases) was compared with maternal serum from 779 randomly selected mothers of nonmalformed children (controls). We found that the average level of FRalpha IgG autoantibodies did not differ significantly among cases and controls (p = 0.71). Slightly higher levels of FRalpha IgM autoantibodies were found among controls compared with cases. This was, however, not statistically significant (p = 0.06), except for mothers of children with isolated cleft lip (p = 0.04). Blocking of folate binding to FR was similar among cases and controls (p = 0.54). The results did not change when stratifying into the cleft subgroups, nor when only isolated oral cleft cases were considered. In conclusion, high maternal autoantibody levels and blocking of folate binding to FRalpha in maternal serum during pregnancy are not associated with an increased risk of oral clefts in the offspring in this population-based cohort.
AB - The objective of this study was to determine whether IgG and IgM autoantibodies to folate receptor alpha (FRalpha) in pregnant women are associated with an increased risk of oral cleft-affected offspring. A case-control study nested in the prospective Danish National Birth Cohort (100,418 pregnancies, enrolled during 1997-2003) was done. Hundred eighty-five children were born with an oral cleft. Maternal serum from their mothers (cases) was compared with maternal serum from 779 randomly selected mothers of nonmalformed children (controls). We found that the average level of FRalpha IgG autoantibodies did not differ significantly among cases and controls (p = 0.71). Slightly higher levels of FRalpha IgM autoantibodies were found among controls compared with cases. This was, however, not statistically significant (p = 0.06), except for mothers of children with isolated cleft lip (p = 0.04). Blocking of folate binding to FR was similar among cases and controls (p = 0.54). The results did not change when stratifying into the cleft subgroups, nor when only isolated oral cleft cases were considered. In conclusion, high maternal autoantibody levels and blocking of folate binding to FRalpha in maternal serum during pregnancy are not associated with an increased risk of oral clefts in the offspring in this population-based cohort.
U2 - 10.1203/PDR.0b013e3181cbd564
DO - 10.1203/PDR.0b013e3181cbd564
M3 - Journal article
C2 - 19952865
VL - 67
SP - 274
EP - 279
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 3
ER -
ID: 21162256