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Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants. / Satterstrom, F Kyle; Walters, Raymond K; Singh, Tarjinder; Wigdor, Emilie M; Lescai, Francesco; Demontis, Ditte; Kosmicki, Jack A; Grove, Jakob; Stevens, Christine; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Palmer, Duncan S; Maller, Julian B; Nordentoft, Merete; Mors, Ole; Robinson, Elise B; Hougaard, David M; Werge, Thomas M.; Bo Mortensen, Preben; Neale, Benjamin M; Børglum, Anders D; Daly, Mark J; iPSYCH-Broad Consortium.
I:
Nature Neuroscience, Bind 22, Nr. 12, 2019, s. 1961-1965.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Satterstrom, FK, Walters, RK, Singh, T, Wigdor, EM, Lescai, F, Demontis, D, Kosmicki, JA, Grove, J, Stevens, C, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Palmer, DS, Maller, JB
, Nordentoft, M, Mors, O, Robinson, EB, Hougaard, DM
, Werge, TM, Bo Mortensen, P, Neale, BM, Børglum, AD, Daly, MJ & iPSYCH-Broad Consortium 2019, '
Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants',
Nature Neuroscience, bind 22, nr. 12, s. 1961-1965.
https://doi.org/10.1038/s41593-019-0527-8APA
Satterstrom, F. K., Walters, R. K., Singh, T., Wigdor, E. M., Lescai, F., Demontis, D., Kosmicki, J. A., Grove, J., Stevens, C., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Palmer, D. S., Maller, J. B.
, Nordentoft, M., Mors, O., Robinson, E. B., Hougaard, D. M.
, Werge, T. M., Bo Mortensen, P., ... iPSYCH-Broad Consortium (2019).
Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants.
Nature Neuroscience,
22(12), 1961-1965.
https://doi.org/10.1038/s41593-019-0527-8Vancouver
Satterstrom FK, Walters RK, Singh T, Wigdor EM, Lescai F, Demontis D o.a.
Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants.
Nature Neuroscience. 2019;22(12):1961-1965.
https://doi.org/10.1038/s41593-019-0527-8Author
Satterstrom, F Kyle ; Walters, Raymond K ; Singh, Tarjinder ; Wigdor, Emilie M ; Lescai, Francesco ; Demontis, Ditte ; Kosmicki, Jack A ; Grove, Jakob ; Stevens, Christine ; Bybjerg-Grauholm, Jonas ; Bækvad-Hansen, Marie ; Palmer, Duncan S ; Maller, Julian B ; Nordentoft, Merete ; Mors, Ole ; Robinson, Elise B ; Hougaard, David M ; Werge, Thomas M. ; Bo Mortensen, Preben ; Neale, Benjamin M ; Børglum, Anders D ; Daly, Mark J ; iPSYCH-Broad Consortium. / Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants. I: Nature Neuroscience. 2019 ; Bind 22, Nr. 12. s. 1961-1965.
Bibtex
@article{c8fb68b525704e559945cd8f8c447e48,
title = "Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants",
abstract = "The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar burden of rare protein-truncating variants in evolutionarily constrained genes, both significantly higher than controls. This motivated a combined analysis across ASD and ADHD, identifying microtubule-associated protein 1A (MAP1A) as a new exome-wide significant gene conferring risk for childhood psychiatric disorders.",
author = "Satterstrom, {F Kyle} and Walters, {Raymond K} and Tarjinder Singh and Wigdor, {Emilie M} and Francesco Lescai and Ditte Demontis and Kosmicki, {Jack A} and Jakob Grove and Christine Stevens and Jonas Bybjerg-Grauholm and Marie B{\ae}kvad-Hansen and Palmer, {Duncan S} and Maller, {Julian B} and Merete Nordentoft and Ole Mors and Robinson, {Elise B} and Hougaard, {David M} and Werge, {Thomas M.} and {Bo Mortensen}, Preben and Neale, {Benjamin M} and B{\o}rglum, {Anders D} and Daly, {Mark J} and {iPSYCH-Broad Consortium}",
year = "2019",
doi = "10.1038/s41593-019-0527-8",
language = "English",
volume = "22",
pages = "1961--1965",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "nature publishing group",
number = "12",
}
RIS
TY - JOUR
T1 - Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants
AU - Satterstrom, F Kyle
AU - Walters, Raymond K
AU - Singh, Tarjinder
AU - Wigdor, Emilie M
AU - Lescai, Francesco
AU - Demontis, Ditte
AU - Kosmicki, Jack A
AU - Grove, Jakob
AU - Stevens, Christine
AU - Bybjerg-Grauholm, Jonas
AU - Bækvad-Hansen, Marie
AU - Palmer, Duncan S
AU - Maller, Julian B
AU - Nordentoft, Merete
AU - Mors, Ole
AU - Robinson, Elise B
AU - Hougaard, David M
AU - Werge, Thomas M.
AU - Bo Mortensen, Preben
AU - Neale, Benjamin M
AU - Børglum, Anders D
AU - Daly, Mark J
AU - iPSYCH-Broad Consortium
PY - 2019
Y1 - 2019
N2 - The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar burden of rare protein-truncating variants in evolutionarily constrained genes, both significantly higher than controls. This motivated a combined analysis across ASD and ADHD, identifying microtubule-associated protein 1A (MAP1A) as a new exome-wide significant gene conferring risk for childhood psychiatric disorders.
AB - The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar burden of rare protein-truncating variants in evolutionarily constrained genes, both significantly higher than controls. This motivated a combined analysis across ASD and ADHD, identifying microtubule-associated protein 1A (MAP1A) as a new exome-wide significant gene conferring risk for childhood psychiatric disorders.
U2 - 10.1038/s41593-019-0527-8
DO - 10.1038/s41593-019-0527-8
M3 - Journal article
C2 - 31768057
VL - 22
SP - 1961
EP - 1965
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
IS - 12
ER -
