Atrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance
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Atrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance. / Jujić, Amra; Nilsson, Peter M; Persson, Margaretha; Holst, Jens Juul; Torekov, Signe Sørensen; Lyssenko, Valeriya; Groop, Leif; Melander, Olle; Magnusson, Martin.
I: The Journal of clinical endocrinology and metabolism, Bind 101, Nr. 4, 27.01.2016, s. 1372-1380.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Atrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance
AU - Jujić, Amra
AU - Nilsson, Peter M
AU - Persson, Margaretha
AU - Holst, Jens Juul
AU - Torekov, Signe Sørensen
AU - Lyssenko, Valeriya
AU - Groop, Leif
AU - Melander, Olle
AU - Magnusson, Martin
PY - 2016/1/27
Y1 - 2016/1/27
N2 - Context We have previously shown that high levels of atrial natriuretic peptides (ANP) are associated with decreased risk of future diabetes development; however, the mechanism behind this relationship is not fully understood.OBJECTIVE: In this study, we prospectively analyzed whether baseline plasma levels of mid-regional proANP (MR-proANP) are associated with insulin resistance and post challenge incretin secretion after long-term follow-up. Design/Setting/Patients MR-proANP was measured in 2243 non-diabetic individuals at baseline examination of Malmö Diet and Cancer Cardiovascular cohort. At re-examination 16.5 years later, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), insulin, glucose and glucagon were measured during an oral glucose tolerance test.RESULTS: Linear regression analyses showed that each 1 SD increment of baseline MR-proANP levels was inversely associated with insulin resistance calculated as HOMA-IR (per 1 SD change β= -0.066, p-value 0.001) at follow-up. Logistic regression analysis showed that each 1 SD increment of baseline ANP levels resulted in lower risk of belonging to upper quartile of HOMA-IR at follow-up (OR 0.88; CI 95 % 0.78-0.99; p-value 0.043). In linear regression analyses each 1 SD increment in baseline MR-proANP levels was associated with greater GIP release (per 1 SD change: β= 0.055; p-value= 0.020) 120 minutes after 75g glucose intake, but not with GLP-1 release (per 1 SD change: β= 0.016; p-value= 0.493) 120 minutes after 75g glucose intake at 16.5 years of follow up.CONCLUSION: Midlife exposure to ANP within the high normal range is associated with lower risk of insulin resistance. Further, midlife exposure to ANP within the high normal range is associated with greater post challenge GIP secretion at follow-up, possibly explaining the lower prevalence of insulin resistance.
AB - Context We have previously shown that high levels of atrial natriuretic peptides (ANP) are associated with decreased risk of future diabetes development; however, the mechanism behind this relationship is not fully understood.OBJECTIVE: In this study, we prospectively analyzed whether baseline plasma levels of mid-regional proANP (MR-proANP) are associated with insulin resistance and post challenge incretin secretion after long-term follow-up. Design/Setting/Patients MR-proANP was measured in 2243 non-diabetic individuals at baseline examination of Malmö Diet and Cancer Cardiovascular cohort. At re-examination 16.5 years later, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), insulin, glucose and glucagon were measured during an oral glucose tolerance test.RESULTS: Linear regression analyses showed that each 1 SD increment of baseline MR-proANP levels was inversely associated with insulin resistance calculated as HOMA-IR (per 1 SD change β= -0.066, p-value 0.001) at follow-up. Logistic regression analysis showed that each 1 SD increment of baseline ANP levels resulted in lower risk of belonging to upper quartile of HOMA-IR at follow-up (OR 0.88; CI 95 % 0.78-0.99; p-value 0.043). In linear regression analyses each 1 SD increment in baseline MR-proANP levels was associated with greater GIP release (per 1 SD change: β= 0.055; p-value= 0.020) 120 minutes after 75g glucose intake, but not with GLP-1 release (per 1 SD change: β= 0.016; p-value= 0.493) 120 minutes after 75g glucose intake at 16.5 years of follow up.CONCLUSION: Midlife exposure to ANP within the high normal range is associated with lower risk of insulin resistance. Further, midlife exposure to ANP within the high normal range is associated with greater post challenge GIP secretion at follow-up, possibly explaining the lower prevalence of insulin resistance.
U2 - 10.1210/jc.2015-3518
DO - 10.1210/jc.2015-3518
M3 - Journal article
C2 - 26815880
VL - 101
SP - 1372
EP - 1380
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -
ID: 154444011