Atrial fibrillation as a risk factor for exercise-induced pulmonary haemorrhage following a standardised exercise test
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Atrial fibrillation as a risk factor for exercise-induced pulmonary haemorrhage following a standardised exercise test. / Hansen, Sanni; Otten, Nina D.; Nissen, Sarah D.; Carstensen, Helena; Hopster-Iversen, Charlotte; Fjeldborg, Julie; Staun, Sophie H.; Fenner, Merle; Hesselkilde, Eva M.; Buhl, Rikke.
I: Equine Veterinary Journal, Bind 56, Nr. 3, 2024, s. 552-561.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Atrial fibrillation as a risk factor for exercise-induced pulmonary haemorrhage following a standardised exercise test
AU - Hansen, Sanni
AU - Otten, Nina D.
AU - Nissen, Sarah D.
AU - Carstensen, Helena
AU - Hopster-Iversen, Charlotte
AU - Fjeldborg, Julie
AU - Staun, Sophie H.
AU - Fenner, Merle
AU - Hesselkilde, Eva M.
AU - Buhl, Rikke
N1 - Publisher Copyright: © 2023 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.
PY - 2024
Y1 - 2024
N2 - Background: Atrial fibrillation (AF) has been proposed as a risk factor for exercise-induced pulmonary haemorrhage (EIPH) due to increased pressure in the left atrium. Objective: To evaluate if AF was associated with EIPH following a standardised exercise test (SET) to fatigue. Study design: Two-arm controlled experiment. Methods: Ten untrained Standardbred mares mean (standard deviation [SD]) age 6 (2) years performed a SET on the treadmill in sinus rhythm (SR) (SET1) and 25–44 days after induction of self-sustained AF (SET2). AF was induced by tachypacing using a pacing device. Endoscopy, including tracheal wash and bronchoalveolar lavage (BAL), was performed 48–72 h before and 24 h after the two SETs. In addition, endoscopic grading of tracheal blood was performed 2 h after each SET. Results: After SET1, none of the horses showed blood in the trachea, and two horses showed erythrophagocytosis. Following SET2, two horses had grade 1 blood in the trachea and free erythrocytes and erythrophagocytosis in the BAL, while another two horses had erythrophagocytosis in the BAL. In SET2, the overall performance on the treadmill was decreased with a lower maximum velocity (SET1 10.3 ± 0.8 m/s vs. SET2 8.9 ± 0.9 m/s, p = 0.004), a higher heart rate (284 ± 21 vs. 221 ± 18 bpm, p = 0.003) and more abnormal QRS complexes (p < 0.001) compared with SET1. Conclusions: Two horses showed signs of EIPH, resulting in visible blood in the trachea, when exercising in AF compared with SR. However, a possible link between EIPH, pulmonary pressure and AF needs to be further elucidated.
AB - Background: Atrial fibrillation (AF) has been proposed as a risk factor for exercise-induced pulmonary haemorrhage (EIPH) due to increased pressure in the left atrium. Objective: To evaluate if AF was associated with EIPH following a standardised exercise test (SET) to fatigue. Study design: Two-arm controlled experiment. Methods: Ten untrained Standardbred mares mean (standard deviation [SD]) age 6 (2) years performed a SET on the treadmill in sinus rhythm (SR) (SET1) and 25–44 days after induction of self-sustained AF (SET2). AF was induced by tachypacing using a pacing device. Endoscopy, including tracheal wash and bronchoalveolar lavage (BAL), was performed 48–72 h before and 24 h after the two SETs. In addition, endoscopic grading of tracheal blood was performed 2 h after each SET. Results: After SET1, none of the horses showed blood in the trachea, and two horses showed erythrophagocytosis. Following SET2, two horses had grade 1 blood in the trachea and free erythrocytes and erythrophagocytosis in the BAL, while another two horses had erythrophagocytosis in the BAL. In SET2, the overall performance on the treadmill was decreased with a lower maximum velocity (SET1 10.3 ± 0.8 m/s vs. SET2 8.9 ± 0.9 m/s, p = 0.004), a higher heart rate (284 ± 21 vs. 221 ± 18 bpm, p = 0.003) and more abnormal QRS complexes (p < 0.001) compared with SET1. Conclusions: Two horses showed signs of EIPH, resulting in visible blood in the trachea, when exercising in AF compared with SR. However, a possible link between EIPH, pulmonary pressure and AF needs to be further elucidated.
KW - arrhythmia
KW - bronchoalveolar lavage
KW - epistaxis
KW - equine asthma
KW - horse
KW - performance
U2 - 10.1111/evj.13995
DO - 10.1111/evj.13995
M3 - Journal article
C2 - 37654233
AN - SCOPUS:85169325903
VL - 56
SP - 552
EP - 561
JO - Equine Veterinary Journal
JF - Equine Veterinary Journal
SN - 0425-1644
IS - 3
ER -
ID: 367539939