Standard
Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness. / Patel, Vivek L; Busch, Evan L; Friebel, Tara M; Cronin, Angel; Leslie, Goska; McGuffog, Lesley; Adlard, Julian; Agata, Simona; Agnarsson, Bjarni A; Ahmed, Munaza; Aittomäki, Kristiina; Alducci, Elisa; Andrulis, Irene L; Arason, Adalgeir; Arnold, Norbert; Artioli, Grazia; Arver, Brita; Auber, Bernd; Azzollini, Jacopo; Balmaña, Judith; Barkardottir, Rosa B; Barnes, Daniel R; Barroso, Alicia; Barrowdale, Daniel; Belotti, Muriel; Benitez, Javier; Bertelsen, Birgitte; Blok, Marinus J; Bodrogi, Istvan; Bonadona, Valérie; Bonanni, Bernardo; Bondavalli, Davide; Boonen, Susanne E; Borde, Julika; Borg, Ake; Bradbury, Angela R; Brady, Angela; Brewer, Carole; Brunet, Joan; Buecher, Bruno; Buys, Saundra S; Cabezas-Camarero, Santiago; Caldés, Trinidad; Caliebe, Almuth; Caligo, Maria A; Calvello, Mariarosaria; Campbell, Ian G; Carnevali, Ileana; Carrasco, Estela; Chan, Tsun L; Chu, Annie T W; Chung, Wendy K; Claes, Kathleen B M; Collaborators, Gemo Study; Collaborators, Embrace; Cook, Jackie; Cortesi, Laura; Couch, Fergus J; Daly, Mary B; Damante, Giuseppe; Darder, Esther; Davidson, Rosemarie; de la Hoya, Miguel; Puppa, Lara Della; Dennis, Joe; Díez, Orland; Ding, Yuan Chun; Ditsch, Nina; Domchek, Susan M; Donaldson, Alan; Dworniczak, Bernd; Easton, Douglas F; Eccles, Diana M; Eeles, Rosalind A; Ehrencrona, Hans; Ejlertsen, Bent; Engel, Christoph; Evans, D Gareth; Faivre, Laurence; Faust, Ulrike; Feliubadaló, Lídia; Foretova, Lenka; Fostira, Florentia; Fountzilas, George; Frost, Debra; García-Barberán, Vanesa; Garre, Pilar; Gauthier-Villars, Marion; Géczi, Lajos; Gehrig, Andrea; Gerdes, Anne-Marie; Gesta, Paul; Giannini, Giuseppe; Glendon, Gord; Godwin, Andrew K; Goldgar, David E; Greene, Mark H; Gutierrez-Barrera, Angelica M; Hahnen, Eric; Hamann, Ute; Hauke, Jan; Herold, Natalie; Hogervorst, Frans B L; Honisch, Ellen; Hopper, John L; Hulick, Peter J; Investigators, KConFab; Investigators, Hebon; Izatt, Louise; Jager, Agnes; James, Paul; Janavicius, Ramunas; Jensen, Uffe Birk; Jensen, Thomas Dyrso; Johannsson, Oskar Th; John, Esther M; Joseph, Vijai; Kang, Eunyoung; Kast, Karin; Kiiski, Johanna I; Kim, Sung-Won; Kim, Zisun; Ko, Kwang-Pil; Konstantopoulou, Irene; Kramer, Gero; Krogh, Lotte; Kruse, Torben A; Kwong, Ava; Larsen, Mirjam; Lasset, Christine; Lautrup, Charlotte; Lazaro, Conxi; Lee, Jihyoun; Lee, Jong Won; Lee, Min Hyuk; Lemke, Johannes; Lesueur, Fabienne; Liljegren, Annelie; Lindblom, Annika; Llovet, Patricia; Lopez-Fernández, Adria; Lopez-Perolio, Irene; Lorca, Victor; Loud, Jennifer T; Ma, Edmond S K; Mai, Phuong L; Manoukian, Siranoush; Mari, Veronique; Martin, Lynn; Matricardi, Laura; Mebirouk, Noura; Medici, Veronica; Meijers-Heijboer, Hanne E J; Meindl, Alfons; Mensenkamp, Arjen R; Miller, Clare; Gomes, Denise Molina; Montagna, Marco; Mooij, Thea M; Moserle, Lidia; Mouret-Fourme, Emmanuelle; Mulligan, Anna Marie; Nathanson, Katherine L; Navratilova, Marie; Nevanlinna, Heli; Niederacher, Dieter; Nielsen, Finn C Cilius; Nikitina-Zake, Liene; Offit, Kenneth; Olah, Edith; Olopade, Olufunmilayo I; Ong, Kai-Ren; Osorio, Ana; Ott, Claus-Eric; Palli, Domenico; Park, Sue K; Parsons, Michael T; Pedersen, Inge Sokilde; Peissel, Bernard; Peixoto, Ana; Pérez-Segura, Pedro; Peterlongo, Paolo; Petersen, Annabeth Høgh; Porteous, Mary E; Pujana, Miguel Angel; Radice, Paolo; Ramser, Juliane; Rantala, Johanna; Rashid, Muhammad U; Rhiem, Kerstin; Rizzolo, Piera; Robson, Mark E; Rookus, Matti A; Rossing, Caroline M; Ruddy, Kathryn J; Santos, Catarina; Saule, Claire; Scarpitta, Rosa; Schmutzler, Rita K; Schuster, Hélène; Senter, Leigha; Seynaeve, Caroline M; Shah, Payal D; Sharma, Priyanka; Shin, Vivian Y; Silvestri, Valentina; Simard, Jacques; Singer, Christian F; Skytte, Anne-Bine; Snape, Katie; Solano, Angela R; Soucy, Penny; Southey, Melissa C; Spurdle, Amanda B; Steele, Linda; Steinemann, Doris; Stoppa-Lyonnet, Dominique; Stradella, Agostina; Sunde, Lone; Sutter, Christian; Tan, Yen Y; Teixeira, Manuel R; Teo, Soo Hwang; Thomassen, Mads; Tibiletti, Maria Grazia; Tischkowitz, Marc; Tognazzo, Silvia; Toland, Amanda E; Tommasi, Stefania; Torres, Diana; Toss, Angela; Trainer, Alison H; Tung, Nadine; van Asperen, Christi J; van der Baan, Frederieke H; van der Kolk, Lizet E; van der Luijt, Rob B; van Hest, Liselotte P; Varesco, Liliana; Varon-Mateeva, Raymonda; Viel, Alessandra; Vierstraete, Jeroen; Villa, Roberta; von Wachenfeldt, Anna; Wagner, Philipp; Wang-Gohrke, Shan; Wappenschmidt, Barbara; Weitzel, Jeffrey N; Wieme, Greet; Yadav, Siddhartha; Yannoukakos, Drakoulis; Yoon, Sook-Yee; Zanzottera, Cristina; Zorn, Kristin K; D'Amico, Anthony V; Freedman, Matthew L; Pomerantz, Mark M; Chenevix-Trench, Georgia; Antoniou, Antonis C; Neuhausen, Susan L; Ottini, Laura; Nielsen, Henriette Roed; Rebbeck, Timothy R.
I:
Cancer Research, Bind 80, Nr. 3, 01.02.2020, s. 624-638.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Patel, VL, Busch, EL, Friebel, TM, Cronin, A, Leslie, G, McGuffog, L, Adlard, J, Agata, S, Agnarsson, BA, Ahmed, M, Aittomäki, K, Alducci, E, Andrulis, IL, Arason, A, Arnold, N, Artioli, G, Arver, B, Auber, B, Azzollini, J, Balmaña, J, Barkardottir, RB, Barnes, DR, Barroso, A, Barrowdale, D, Belotti, M, Benitez, J, Bertelsen, B, Blok, MJ, Bodrogi, I, Bonadona, V, Bonanni, B, Bondavalli, D, Boonen, SE, Borde, J, Borg, A, Bradbury, AR, Brady, A, Brewer, C, Brunet, J, Buecher, B, Buys, SS, Cabezas-Camarero, S, Caldés, T, Caliebe, A, Caligo, MA, Calvello, M, Campbell, IG, Carnevali, I, Carrasco, E, Chan, TL, Chu, ATW, Chung, WK, Claes, KBM, Collaborators, GS, Collaborators, E, Cook, J, Cortesi, L, Couch, FJ, Daly, MB, Damante, G, Darder, E, Davidson, R, de la Hoya, M, Puppa, LD, Dennis, J, Díez, O, Ding, YC, Ditsch, N, Domchek, SM, Donaldson, A, Dworniczak, B, Easton, DF, Eccles, DM, Eeles, RA, Ehrencrona, H
, Ejlertsen, B, Engel, C, Evans, DG, Faivre, L, Faust, U, Feliubadaló, L, Foretova, L, Fostira, F, Fountzilas, G, Frost, D, García-Barberán, V, Garre, P, Gauthier-Villars, M, Géczi, L, Gehrig, A
, Gerdes, A-M, Gesta, P, Giannini, G, Glendon, G, Godwin, AK, Goldgar, DE, Greene, MH, Gutierrez-Barrera, AM, Hahnen, E, Hamann, U, Hauke, J, Herold, N, Hogervorst, FBL, Honisch, E, Hopper, JL, Hulick, PJ, Investigators, KC, Investigators, H, Izatt, L, Jager, A, James, P, Janavicius, R, Jensen, UB, Jensen, TD, Johannsson, OT, John, EM, Joseph, V, Kang, E, Kast, K, Kiiski, JI, Kim, S-W, Kim, Z, Ko, K-P, Konstantopoulou, I, Kramer, G, Krogh, L, Kruse, TA, Kwong, A, Larsen, M, Lasset, C, Lautrup, C, Lazaro, C, Lee, J, Lee, JW, Lee, MH, Lemke, J, Lesueur, F, Liljegren, A, Lindblom, A, Llovet, P, Lopez-Fernández, A, Lopez-Perolio, I, Lorca, V, Loud, JT, Ma, ESK, Mai, PL, Manoukian, S, Mari, V, Martin, L, Matricardi, L, Mebirouk, N, Medici, V, Meijers-Heijboer, HEJ, Meindl, A, Mensenkamp, AR, Miller, C, Gomes, DM, Montagna, M, Mooij, TM, Moserle, L, Mouret-Fourme, E, Mulligan, AM, Nathanson, KL, Navratilova, M, Nevanlinna, H, Niederacher, D
, Nielsen, FCC, Nikitina-Zake, L, Offit, K, Olah, E, Olopade, OI, Ong, K-R, Osorio, A, Ott, C-E, Palli, D, Park, SK, Parsons, MT, Pedersen, IS, Peissel, B, Peixoto, A, Pérez-Segura, P, Peterlongo, P, Petersen, AH, Porteous, ME, Pujana, MA, Radice, P, Ramser, J, Rantala, J, Rashid, MU, Rhiem, K, Rizzolo, P, Robson, ME, Rookus, MA, Rossing, CM, Ruddy, KJ, Santos, C, Saule, C, Scarpitta, R, Schmutzler, RK, Schuster, H, Senter, L, Seynaeve, CM, Shah, PD, Sharma, P, Shin, VY, Silvestri, V, Simard, J, Singer, CF, Skytte, A-B, Snape, K, Solano, AR, Soucy, P, Southey, MC, Spurdle, AB, Steele, L, Steinemann, D, Stoppa-Lyonnet, D, Stradella, A, Sunde, L, Sutter, C, Tan, YY, Teixeira, MR, Teo, SH, Thomassen, M, Tibiletti, MG, Tischkowitz, M, Tognazzo, S, Toland, AE, Tommasi, S, Torres, D, Toss, A, Trainer, AH, Tung, N, van Asperen, CJ, van der Baan, FH, van der Kolk, LE, van der Luijt, RB, van Hest, LP, Varesco, L, Varon-Mateeva, R, Viel, A, Vierstraete, J, Villa, R, von Wachenfeldt, A, Wagner, P, Wang-Gohrke, S, Wappenschmidt, B, Weitzel, JN, Wieme, G, Yadav, S, Yannoukakos, D, Yoon, S-Y, Zanzottera, C, Zorn, KK, D'Amico, AV, Freedman, ML, Pomerantz, MM, Chenevix-Trench, G, Antoniou, AC, Neuhausen, SL, Ottini, L, Nielsen, HR & Rebbeck, TR 2020, '
Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness',
Cancer Research, bind 80, nr. 3, s. 624-638.
https://doi.org/10.1158/0008-5472.CAN-19-1840APA
Patel, V. L., Busch, E. L., Friebel, T. M., Cronin, A., Leslie, G., McGuffog, L., Adlard, J., Agata, S., Agnarsson, B. A., Ahmed, M., Aittomäki, K., Alducci, E., Andrulis, I. L., Arason, A., Arnold, N., Artioli, G., Arver, B., Auber, B., Azzollini, J., ... Rebbeck, T. R. (2020).
Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness.
Cancer Research,
80(3), 624-638.
https://doi.org/10.1158/0008-5472.CAN-19-1840Vancouver
Patel VL, Busch EL, Friebel TM, Cronin A, Leslie G, McGuffog L o.a.
Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness.
Cancer Research. 2020 feb. 1;80(3):624-638.
https://doi.org/10.1158/0008-5472.CAN-19-1840Author
Patel, Vivek L ; Busch, Evan L ; Friebel, Tara M ; Cronin, Angel ; Leslie, Goska ; McGuffog, Lesley ; Adlard, Julian ; Agata, Simona ; Agnarsson, Bjarni A ; Ahmed, Munaza ; Aittomäki, Kristiina ; Alducci, Elisa ; Andrulis, Irene L ; Arason, Adalgeir ; Arnold, Norbert ; Artioli, Grazia ; Arver, Brita ; Auber, Bernd ; Azzollini, Jacopo ; Balmaña, Judith ; Barkardottir, Rosa B ; Barnes, Daniel R ; Barroso, Alicia ; Barrowdale, Daniel ; Belotti, Muriel ; Benitez, Javier ; Bertelsen, Birgitte ; Blok, Marinus J ; Bodrogi, Istvan ; Bonadona, Valérie ; Bonanni, Bernardo ; Bondavalli, Davide ; Boonen, Susanne E ; Borde, Julika ; Borg, Ake ; Bradbury, Angela R ; Brady, Angela ; Brewer, Carole ; Brunet, Joan ; Buecher, Bruno ; Buys, Saundra S ; Cabezas-Camarero, Santiago ; Caldés, Trinidad ; Caliebe, Almuth ; Caligo, Maria A ; Calvello, Mariarosaria ; Campbell, Ian G ; Carnevali, Ileana ; Carrasco, Estela ; Chan, Tsun L ; Chu, Annie T W ; Chung, Wendy K ; Claes, Kathleen B M ; Collaborators, Gemo Study ; Collaborators, Embrace ; Cook, Jackie ; Cortesi, Laura ; Couch, Fergus J ; Daly, Mary B ; Damante, Giuseppe ; Darder, Esther ; Davidson, Rosemarie ; de la Hoya, Miguel ; Puppa, Lara Della ; Dennis, Joe ; Díez, Orland ; Ding, Yuan Chun ; Ditsch, Nina ; Domchek, Susan M ; Donaldson, Alan ; Dworniczak, Bernd ; Easton, Douglas F ; Eccles, Diana M ; Eeles, Rosalind A ; Ehrencrona, Hans ; Ejlertsen, Bent ; Engel, Christoph ; Evans, D Gareth ; Faivre, Laurence ; Faust, Ulrike ; Feliubadaló, Lídia ; Foretova, Lenka ; Fostira, Florentia ; Fountzilas, George ; Frost, Debra ; García-Barberán, Vanesa ; Garre, Pilar ; Gauthier-Villars, Marion ; Géczi, Lajos ; Gehrig, Andrea ; Gerdes, Anne-Marie ; Gesta, Paul ; Giannini, Giuseppe ; Glendon, Gord ; Godwin, Andrew K ; Goldgar, David E ; Greene, Mark H ; Gutierrez-Barrera, Angelica M ; Hahnen, Eric ; Hamann, Ute ; Hauke, Jan ; Herold, Natalie ; Hogervorst, Frans B L ; Honisch, Ellen ; Hopper, John L ; Hulick, Peter J ; Investigators, KConFab ; Investigators, Hebon ; Izatt, Louise ; Jager, Agnes ; James, Paul ; Janavicius, Ramunas ; Jensen, Uffe Birk ; Jensen, Thomas Dyrso ; Johannsson, Oskar Th ; John, Esther M ; Joseph, Vijai ; Kang, Eunyoung ; Kast, Karin ; Kiiski, Johanna I ; Kim, Sung-Won ; Kim, Zisun ; Ko, Kwang-Pil ; Konstantopoulou, Irene ; Kramer, Gero ; Krogh, Lotte ; Kruse, Torben A ; Kwong, Ava ; Larsen, Mirjam ; Lasset, Christine ; Lautrup, Charlotte ; Lazaro, Conxi ; Lee, Jihyoun ; Lee, Jong Won ; Lee, Min Hyuk ; Lemke, Johannes ; Lesueur, Fabienne ; Liljegren, Annelie ; Lindblom, Annika ; Llovet, Patricia ; Lopez-Fernández, Adria ; Lopez-Perolio, Irene ; Lorca, Victor ; Loud, Jennifer T ; Ma, Edmond S K ; Mai, Phuong L ; Manoukian, Siranoush ; Mari, Veronique ; Martin, Lynn ; Matricardi, Laura ; Mebirouk, Noura ; Medici, Veronica ; Meijers-Heijboer, Hanne E J ; Meindl, Alfons ; Mensenkamp, Arjen R ; Miller, Clare ; Gomes, Denise Molina ; Montagna, Marco ; Mooij, Thea M ; Moserle, Lidia ; Mouret-Fourme, Emmanuelle ; Mulligan, Anna Marie ; Nathanson, Katherine L ; Navratilova, Marie ; Nevanlinna, Heli ; Niederacher, Dieter ; Nielsen, Finn C Cilius ; Nikitina-Zake, Liene ; Offit, Kenneth ; Olah, Edith ; Olopade, Olufunmilayo I ; Ong, Kai-Ren ; Osorio, Ana ; Ott, Claus-Eric ; Palli, Domenico ; Park, Sue K ; Parsons, Michael T ; Pedersen, Inge Sokilde ; Peissel, Bernard ; Peixoto, Ana ; Pérez-Segura, Pedro ; Peterlongo, Paolo ; Petersen, Annabeth Høgh ; Porteous, Mary E ; Pujana, Miguel Angel ; Radice, Paolo ; Ramser, Juliane ; Rantala, Johanna ; Rashid, Muhammad U ; Rhiem, Kerstin ; Rizzolo, Piera ; Robson, Mark E ; Rookus, Matti A ; Rossing, Caroline M ; Ruddy, Kathryn J ; Santos, Catarina ; Saule, Claire ; Scarpitta, Rosa ; Schmutzler, Rita K ; Schuster, Hélène ; Senter, Leigha ; Seynaeve, Caroline M ; Shah, Payal D ; Sharma, Priyanka ; Shin, Vivian Y ; Silvestri, Valentina ; Simard, Jacques ; Singer, Christian F ; Skytte, Anne-Bine ; Snape, Katie ; Solano, Angela R ; Soucy, Penny ; Southey, Melissa C ; Spurdle, Amanda B ; Steele, Linda ; Steinemann, Doris ; Stoppa-Lyonnet, Dominique ; Stradella, Agostina ; Sunde, Lone ; Sutter, Christian ; Tan, Yen Y ; Teixeira, Manuel R ; Teo, Soo Hwang ; Thomassen, Mads ; Tibiletti, Maria Grazia ; Tischkowitz, Marc ; Tognazzo, Silvia ; Toland, Amanda E ; Tommasi, Stefania ; Torres, Diana ; Toss, Angela ; Trainer, Alison H ; Tung, Nadine ; van Asperen, Christi J ; van der Baan, Frederieke H ; van der Kolk, Lizet E ; van der Luijt, Rob B ; van Hest, Liselotte P ; Varesco, Liliana ; Varon-Mateeva, Raymonda ; Viel, Alessandra ; Vierstraete, Jeroen ; Villa, Roberta ; von Wachenfeldt, Anna ; Wagner, Philipp ; Wang-Gohrke, Shan ; Wappenschmidt, Barbara ; Weitzel, Jeffrey N ; Wieme, Greet ; Yadav, Siddhartha ; Yannoukakos, Drakoulis ; Yoon, Sook-Yee ; Zanzottera, Cristina ; Zorn, Kristin K ; D'Amico, Anthony V ; Freedman, Matthew L ; Pomerantz, Mark M ; Chenevix-Trench, Georgia ; Antoniou, Antonis C ; Neuhausen, Susan L ; Ottini, Laura ; Nielsen, Henriette Roed ; Rebbeck, Timothy R. / Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness. I: Cancer Research. 2020 ; Bind 80, Nr. 3. s. 624-638.
Bibtex
@article{b0f2d0b60ff141adbc3741b897188266,
title = "Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness",
abstract = "Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, BRCA1 Protein/genetics, BRCA2 Protein/genetics, Genetic Association Studies, Genetic Predisposition to Disease, Genomics/methods, Heterozygote, Humans, Male, Middle Aged, Mutation, Prognosis, Prostatic Neoplasms/genetics, Risk Factors, Young Adult",
author = "Patel, {Vivek L} and Busch, {Evan L} and Friebel, {Tara M} and Angel Cronin and Goska Leslie and Lesley McGuffog and Julian Adlard and Simona Agata and Agnarsson, {Bjarni A} and Munaza Ahmed and Kristiina Aittom{\"a}ki and Elisa Alducci and Andrulis, {Irene L} and Adalgeir Arason and Norbert Arnold and Grazia Artioli and Brita Arver and Bernd Auber and Jacopo Azzollini and Judith Balma{\~n}a and Barkardottir, {Rosa B} and Barnes, {Daniel R} and Alicia Barroso and Daniel Barrowdale and Muriel Belotti and Javier Benitez and Birgitte Bertelsen and Blok, {Marinus J} and Istvan Bodrogi and Val{\'e}rie Bonadona and Bernardo Bonanni and Davide Bondavalli and Boonen, {Susanne E} and Julika Borde and Ake Borg and Bradbury, {Angela R} and Angela Brady and Carole Brewer and Joan Brunet and Bruno Buecher and Buys, {Saundra S} and Santiago Cabezas-Camarero and Trinidad Cald{\'e}s and Almuth Caliebe and Caligo, {Maria A} and Mariarosaria Calvello and Campbell, {Ian G} and Ileana Carnevali and Estela Carrasco and Chan, {Tsun L} and Chu, {Annie T W} and Chung, {Wendy K} and Claes, {Kathleen B M} and Collaborators, {Gemo Study} and Embrace Collaborators and Jackie Cook and Laura Cortesi and Couch, {Fergus J} and Daly, {Mary B} and Giuseppe Damante and Esther Darder and Rosemarie Davidson and {de la Hoya}, Miguel and Puppa, {Lara Della} and Joe Dennis and Orland D{\'i}ez and Ding, {Yuan Chun} and Nina Ditsch and Domchek, {Susan M} and Alan Donaldson and Bernd Dworniczak and Easton, {Douglas F} and Eccles, {Diana M} and Eeles, {Rosalind A} and Hans Ehrencrona and Bent Ejlertsen and Christoph Engel and Evans, {D Gareth} and Laurence Faivre and Ulrike Faust and L{\'i}dia Feliubadal{\'o} and Lenka Foretova and Florentia Fostira and George Fountzilas and Debra Frost and Vanesa Garc{\'i}a-Barber{\'a}n and Pilar Garre and Marion Gauthier-Villars and Lajos G{\'e}czi and Andrea Gehrig and Anne-Marie Gerdes and Paul Gesta and Giuseppe Giannini and Gord Glendon and Godwin, {Andrew K} and Goldgar, {David E} and Greene, {Mark H} and Gutierrez-Barrera, {Angelica M} and Eric Hahnen and Ute Hamann and Jan Hauke and Natalie Herold and Hogervorst, {Frans B L} and Ellen Honisch and Hopper, {John L} and Hulick, {Peter J} and KConFab Investigators and Hebon Investigators and Louise Izatt and Agnes Jager and Paul James and Ramunas Janavicius and Jensen, {Uffe Birk} and Jensen, {Thomas Dyrso} and Johannsson, {Oskar Th} and John, {Esther M} and Vijai Joseph and Eunyoung Kang and Karin Kast and Kiiski, {Johanna I} and Sung-Won Kim and Zisun Kim and Kwang-Pil Ko and Irene Konstantopoulou and Gero Kramer and Lotte Krogh and Kruse, {Torben A} and Ava Kwong and Mirjam Larsen and Christine Lasset and Charlotte Lautrup and Conxi Lazaro and Jihyoun Lee and Lee, {Jong Won} and Lee, {Min Hyuk} and Johannes Lemke and Fabienne Lesueur and Annelie Liljegren and Annika Lindblom and Patricia Llovet and Adria Lopez-Fern{\'a}ndez and Irene Lopez-Perolio and Victor Lorca and Loud, {Jennifer T} and Ma, {Edmond S K} and Mai, {Phuong L} and Siranoush Manoukian and Veronique Mari and Lynn Martin and Laura Matricardi and Noura Mebirouk and Veronica Medici and Meijers-Heijboer, {Hanne E J} and Alfons Meindl and Mensenkamp, {Arjen R} and Clare Miller and Gomes, {Denise Molina} and Marco Montagna and Mooij, {Thea M} and Lidia Moserle and Emmanuelle Mouret-Fourme and Mulligan, {Anna Marie} and Nathanson, {Katherine L} and Marie Navratilova and Heli Nevanlinna and Dieter Niederacher and Nielsen, {Finn C Cilius} and Liene Nikitina-Zake and Kenneth Offit and Edith Olah and Olopade, {Olufunmilayo I} and Kai-Ren Ong and Ana Osorio and Claus-Eric Ott and Domenico Palli and Park, {Sue K} and Parsons, {Michael T} and Pedersen, {Inge Sokilde} and Bernard Peissel and Ana Peixoto and Pedro P{\'e}rez-Segura and Paolo Peterlongo and Petersen, {Annabeth H{\o}gh} and Porteous, {Mary E} and Pujana, {Miguel Angel} and Paolo Radice and Juliane Ramser and Johanna Rantala and Rashid, {Muhammad U} and Kerstin Rhiem and Piera Rizzolo and Robson, {Mark E} and Rookus, {Matti A} and Rossing, {Caroline M} and Ruddy, {Kathryn J} and Catarina Santos and Claire Saule and Rosa Scarpitta and Schmutzler, {Rita K} and H{\'e}l{\`e}ne Schuster and Leigha Senter and Seynaeve, {Caroline M} and Shah, {Payal D} and Priyanka Sharma and Shin, {Vivian Y} and Valentina Silvestri and Jacques Simard and Singer, {Christian F} and Anne-Bine Skytte and Katie Snape and Solano, {Angela R} and Penny Soucy and Southey, {Melissa C} and Spurdle, {Amanda B} and Linda Steele and Doris Steinemann and Dominique Stoppa-Lyonnet and Agostina Stradella and Lone Sunde and Christian Sutter and Tan, {Yen Y} and Teixeira, {Manuel R} and Teo, {Soo Hwang} and Mads Thomassen and Tibiletti, {Maria Grazia} and Marc Tischkowitz and Silvia Tognazzo and Toland, {Amanda E} and Stefania Tommasi and Diana Torres and Angela Toss and Trainer, {Alison H} and Nadine Tung and {van Asperen}, {Christi J} and {van der Baan}, {Frederieke H} and {van der Kolk}, {Lizet E} and {van der Luijt}, {Rob B} and {van Hest}, {Liselotte P} and Liliana Varesco and Raymonda Varon-Mateeva and Alessandra Viel and Jeroen Vierstraete and Roberta Villa and {von Wachenfeldt}, Anna and Philipp Wagner and Shan Wang-Gohrke and Barbara Wappenschmidt and Weitzel, {Jeffrey N} and Greet Wieme and Siddhartha Yadav and Drakoulis Yannoukakos and Sook-Yee Yoon and Cristina Zanzottera and Zorn, {Kristin K} and D'Amico, {Anthony V} and Freedman, {Matthew L} and Pomerantz, {Mark M} and Georgia Chenevix-Trench and Antoniou, {Antonis C} and Neuhausen, {Susan L} and Laura Ottini and Nielsen, {Henriette Roed} and Rebbeck, {Timothy R}",
note = "{\textcopyright}2019 American Association for Cancer Research.",
year = "2020",
month = feb,
day = "1",
doi = "10.1158/0008-5472.CAN-19-1840",
language = "English",
volume = "80",
pages = "624--638",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research",
number = "3",
}
RIS
TY - JOUR
T1 - Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness
AU - Patel, Vivek L
AU - Busch, Evan L
AU - Friebel, Tara M
AU - Cronin, Angel
AU - Leslie, Goska
AU - McGuffog, Lesley
AU - Adlard, Julian
AU - Agata, Simona
AU - Agnarsson, Bjarni A
AU - Ahmed, Munaza
AU - Aittomäki, Kristiina
AU - Alducci, Elisa
AU - Andrulis, Irene L
AU - Arason, Adalgeir
AU - Arnold, Norbert
AU - Artioli, Grazia
AU - Arver, Brita
AU - Auber, Bernd
AU - Azzollini, Jacopo
AU - Balmaña, Judith
AU - Barkardottir, Rosa B
AU - Barnes, Daniel R
AU - Barroso, Alicia
AU - Barrowdale, Daniel
AU - Belotti, Muriel
AU - Benitez, Javier
AU - Bertelsen, Birgitte
AU - Blok, Marinus J
AU - Bodrogi, Istvan
AU - Bonadona, Valérie
AU - Bonanni, Bernardo
AU - Bondavalli, Davide
AU - Boonen, Susanne E
AU - Borde, Julika
AU - Borg, Ake
AU - Bradbury, Angela R
AU - Brady, Angela
AU - Brewer, Carole
AU - Brunet, Joan
AU - Buecher, Bruno
AU - Buys, Saundra S
AU - Cabezas-Camarero, Santiago
AU - Caldés, Trinidad
AU - Caliebe, Almuth
AU - Caligo, Maria A
AU - Calvello, Mariarosaria
AU - Campbell, Ian G
AU - Carnevali, Ileana
AU - Carrasco, Estela
AU - Chan, Tsun L
AU - Chu, Annie T W
AU - Chung, Wendy K
AU - Claes, Kathleen B M
AU - Collaborators, Gemo Study
AU - Collaborators, Embrace
AU - Cook, Jackie
AU - Cortesi, Laura
AU - Couch, Fergus J
AU - Daly, Mary B
AU - Damante, Giuseppe
AU - Darder, Esther
AU - Davidson, Rosemarie
AU - de la Hoya, Miguel
AU - Puppa, Lara Della
AU - Dennis, Joe
AU - Díez, Orland
AU - Ding, Yuan Chun
AU - Ditsch, Nina
AU - Domchek, Susan M
AU - Donaldson, Alan
AU - Dworniczak, Bernd
AU - Easton, Douglas F
AU - Eccles, Diana M
AU - Eeles, Rosalind A
AU - Ehrencrona, Hans
AU - Ejlertsen, Bent
AU - Engel, Christoph
AU - Evans, D Gareth
AU - Faivre, Laurence
AU - Faust, Ulrike
AU - Feliubadaló, Lídia
AU - Foretova, Lenka
AU - Fostira, Florentia
AU - Fountzilas, George
AU - Frost, Debra
AU - García-Barberán, Vanesa
AU - Garre, Pilar
AU - Gauthier-Villars, Marion
AU - Géczi, Lajos
AU - Gehrig, Andrea
AU - Gerdes, Anne-Marie
AU - Gesta, Paul
AU - Giannini, Giuseppe
AU - Glendon, Gord
AU - Godwin, Andrew K
AU - Goldgar, David E
AU - Greene, Mark H
AU - Gutierrez-Barrera, Angelica M
AU - Hahnen, Eric
AU - Hamann, Ute
AU - Hauke, Jan
AU - Herold, Natalie
AU - Hogervorst, Frans B L
AU - Honisch, Ellen
AU - Hopper, John L
AU - Hulick, Peter J
AU - Investigators, KConFab
AU - Investigators, Hebon
AU - Izatt, Louise
AU - Jager, Agnes
AU - James, Paul
AU - Janavicius, Ramunas
AU - Jensen, Uffe Birk
AU - Jensen, Thomas Dyrso
AU - Johannsson, Oskar Th
AU - John, Esther M
AU - Joseph, Vijai
AU - Kang, Eunyoung
AU - Kast, Karin
AU - Kiiski, Johanna I
AU - Kim, Sung-Won
AU - Kim, Zisun
AU - Ko, Kwang-Pil
AU - Konstantopoulou, Irene
AU - Kramer, Gero
AU - Krogh, Lotte
AU - Kruse, Torben A
AU - Kwong, Ava
AU - Larsen, Mirjam
AU - Lasset, Christine
AU - Lautrup, Charlotte
AU - Lazaro, Conxi
AU - Lee, Jihyoun
AU - Lee, Jong Won
AU - Lee, Min Hyuk
AU - Lemke, Johannes
AU - Lesueur, Fabienne
AU - Liljegren, Annelie
AU - Lindblom, Annika
AU - Llovet, Patricia
AU - Lopez-Fernández, Adria
AU - Lopez-Perolio, Irene
AU - Lorca, Victor
AU - Loud, Jennifer T
AU - Ma, Edmond S K
AU - Mai, Phuong L
AU - Manoukian, Siranoush
AU - Mari, Veronique
AU - Martin, Lynn
AU - Matricardi, Laura
AU - Mebirouk, Noura
AU - Medici, Veronica
AU - Meijers-Heijboer, Hanne E J
AU - Meindl, Alfons
AU - Mensenkamp, Arjen R
AU - Miller, Clare
AU - Gomes, Denise Molina
AU - Montagna, Marco
AU - Mooij, Thea M
AU - Moserle, Lidia
AU - Mouret-Fourme, Emmanuelle
AU - Mulligan, Anna Marie
AU - Nathanson, Katherine L
AU - Navratilova, Marie
AU - Nevanlinna, Heli
AU - Niederacher, Dieter
AU - Nielsen, Finn C Cilius
AU - Nikitina-Zake, Liene
AU - Offit, Kenneth
AU - Olah, Edith
AU - Olopade, Olufunmilayo I
AU - Ong, Kai-Ren
AU - Osorio, Ana
AU - Ott, Claus-Eric
AU - Palli, Domenico
AU - Park, Sue K
AU - Parsons, Michael T
AU - Pedersen, Inge Sokilde
AU - Peissel, Bernard
AU - Peixoto, Ana
AU - Pérez-Segura, Pedro
AU - Peterlongo, Paolo
AU - Petersen, Annabeth Høgh
AU - Porteous, Mary E
AU - Pujana, Miguel Angel
AU - Radice, Paolo
AU - Ramser, Juliane
AU - Rantala, Johanna
AU - Rashid, Muhammad U
AU - Rhiem, Kerstin
AU - Rizzolo, Piera
AU - Robson, Mark E
AU - Rookus, Matti A
AU - Rossing, Caroline M
AU - Ruddy, Kathryn J
AU - Santos, Catarina
AU - Saule, Claire
AU - Scarpitta, Rosa
AU - Schmutzler, Rita K
AU - Schuster, Hélène
AU - Senter, Leigha
AU - Seynaeve, Caroline M
AU - Shah, Payal D
AU - Sharma, Priyanka
AU - Shin, Vivian Y
AU - Silvestri, Valentina
AU - Simard, Jacques
AU - Singer, Christian F
AU - Skytte, Anne-Bine
AU - Snape, Katie
AU - Solano, Angela R
AU - Soucy, Penny
AU - Southey, Melissa C
AU - Spurdle, Amanda B
AU - Steele, Linda
AU - Steinemann, Doris
AU - Stoppa-Lyonnet, Dominique
AU - Stradella, Agostina
AU - Sunde, Lone
AU - Sutter, Christian
AU - Tan, Yen Y
AU - Teixeira, Manuel R
AU - Teo, Soo Hwang
AU - Thomassen, Mads
AU - Tibiletti, Maria Grazia
AU - Tischkowitz, Marc
AU - Tognazzo, Silvia
AU - Toland, Amanda E
AU - Tommasi, Stefania
AU - Torres, Diana
AU - Toss, Angela
AU - Trainer, Alison H
AU - Tung, Nadine
AU - van Asperen, Christi J
AU - van der Baan, Frederieke H
AU - van der Kolk, Lizet E
AU - van der Luijt, Rob B
AU - van Hest, Liselotte P
AU - Varesco, Liliana
AU - Varon-Mateeva, Raymonda
AU - Viel, Alessandra
AU - Vierstraete, Jeroen
AU - Villa, Roberta
AU - von Wachenfeldt, Anna
AU - Wagner, Philipp
AU - Wang-Gohrke, Shan
AU - Wappenschmidt, Barbara
AU - Weitzel, Jeffrey N
AU - Wieme, Greet
AU - Yadav, Siddhartha
AU - Yannoukakos, Drakoulis
AU - Yoon, Sook-Yee
AU - Zanzottera, Cristina
AU - Zorn, Kristin K
AU - D'Amico, Anthony V
AU - Freedman, Matthew L
AU - Pomerantz, Mark M
AU - Chenevix-Trench, Georgia
AU - Antoniou, Antonis C
AU - Neuhausen, Susan L
AU - Ottini, Laura
AU - Nielsen, Henriette Roed
AU - Rebbeck, Timothy R
N1 - ©2019 American Association for Cancer Research.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.
AB - Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - BRCA1 Protein/genetics
KW - BRCA2 Protein/genetics
KW - Genetic Association Studies
KW - Genetic Predisposition to Disease
KW - Genomics/methods
KW - Heterozygote
KW - Humans
KW - Male
KW - Middle Aged
KW - Mutation
KW - Prognosis
KW - Prostatic Neoplasms/genetics
KW - Risk Factors
KW - Young Adult
U2 - 10.1158/0008-5472.CAN-19-1840
DO - 10.1158/0008-5472.CAN-19-1840
M3 - Journal article
C2 - 31723001
VL - 80
SP - 624
EP - 638
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 3
ER -
