Association of bisphenol A, bisphenol F, and bisphenol S with ADHD symptoms in children
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Association of bisphenol A, bisphenol F, and bisphenol S with ADHD symptoms in children. / Kim, Johanna Inhyang; Lee, Young Ah; Shin, Choong Ho; Hong, Yun-Chul; Kim, Bung-Nyun; Lim, Youn-Hee.
I: Environment International, Bind 161, 107093, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Association of bisphenol A, bisphenol F, and bisphenol S with ADHD symptoms in children
AU - Kim, Johanna Inhyang
AU - Lee, Young Ah
AU - Shin, Choong Ho
AU - Hong, Yun-Chul
AU - Kim, Bung-Nyun
AU - Lim, Youn-Hee
N1 - Copyright © 2022. Published by Elsevier Ltd.
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Bisphenol A (BPA) has been linked to attention-deficit/hyperactivity disorder (ADHD) symptoms, but the neurotoxic effects of bisphenol substitutes such as bisphenol F (BPF) and S (BPS) have not been well investigated. We investigated the associations between BPA, BPF, and BPS with ADHD symptoms at multiple time points in children.METHODS: The levels of BPA (at ages 4, 6, and 8), BPF (at ages 6 and 8), and BPS (at ages 6 and 8) were measured in 619 children. Because of the low detection frequency of BPF and BPS levels, participants were divided into categories (RESULTS: BPA was detected in most participants (>97%), whereas BPF and BPS were less frequently detected (age 6: 17.5% for BPF and 42.0% for BPS; age 8: 51.6% for BPF and 73.3% for BPS). Doubling in BPA levels was associated with increased ARS scores by 4.7% (95% confidence intervals [CI]: 0.5, 9.2) at age 6. The association was greater with BPA levels higher than 3.0 μg/g creatinine (24.2% [95% CI: 15.5, 33.6] increase). The BPF ≥ LOD group had 10.8% (95% CI: 1.2, 21.4) higher ARS scores than the BPF < LOD group. The BPS ≥ median group had 11.4% (95% CI: 2.0, 21.7) higher ARS scores than the BPS < LOD group.CONCLUSION: All bisphenols, in particular those at or above the LOD or median levels, were associated with ADHD symptoms at age 6. Further prospective studies are warranted to determine causal inference.
AB - BACKGROUND: Bisphenol A (BPA) has been linked to attention-deficit/hyperactivity disorder (ADHD) symptoms, but the neurotoxic effects of bisphenol substitutes such as bisphenol F (BPF) and S (BPS) have not been well investigated. We investigated the associations between BPA, BPF, and BPS with ADHD symptoms at multiple time points in children.METHODS: The levels of BPA (at ages 4, 6, and 8), BPF (at ages 6 and 8), and BPS (at ages 6 and 8) were measured in 619 children. Because of the low detection frequency of BPF and BPS levels, participants were divided into categories (RESULTS: BPA was detected in most participants (>97%), whereas BPF and BPS were less frequently detected (age 6: 17.5% for BPF and 42.0% for BPS; age 8: 51.6% for BPF and 73.3% for BPS). Doubling in BPA levels was associated with increased ARS scores by 4.7% (95% confidence intervals [CI]: 0.5, 9.2) at age 6. The association was greater with BPA levels higher than 3.0 μg/g creatinine (24.2% [95% CI: 15.5, 33.6] increase). The BPF ≥ LOD group had 10.8% (95% CI: 1.2, 21.4) higher ARS scores than the BPF < LOD group. The BPS ≥ median group had 11.4% (95% CI: 2.0, 21.7) higher ARS scores than the BPS < LOD group.CONCLUSION: All bisphenols, in particular those at or above the LOD or median levels, were associated with ADHD symptoms at age 6. Further prospective studies are warranted to determine causal inference.
U2 - 10.1016/j.envint.2022.107093
DO - 10.1016/j.envint.2022.107093
M3 - Journal article
C2 - 35077929
VL - 161
JO - Environment international
JF - Environment international
SN - 0160-4120
M1 - 107093
ER -
ID: 290974960