Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study
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Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV : The Swiss HIV Cohort Study. / Schwenke, Johannes M.; Thorball, Christian W.; Schoepf, Isabella C.; Ryom, Lene; Hasse, B.; Lamy, Olivier; Calmy, Alexandra; Wandeler, G.; Marzolini, C.; Kahlert, Christian R.; Bernasconi, Enos; Kouyos, R. D.; Günthard, H. F.; Ledergerber, Bruno; Fellay, Jacques; Burkhalter, Felix; Tarr, P.; Swiss HIV Cohort Study (SHCS).
I: Journal of Infectious Diseases, Bind 228, Nr. 6, 2023, s. 742-750.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV
T2 - The Swiss HIV Cohort Study
AU - Schwenke, Johannes M.
AU - Thorball, Christian W.
AU - Schoepf, Isabella C.
AU - Ryom, Lene
AU - Hasse, B.
AU - Lamy, Olivier
AU - Calmy, Alexandra
AU - Wandeler, G.
AU - Marzolini, C.
AU - Kahlert, Christian R.
AU - Bernasconi, Enos
AU - Kouyos, R. D.
AU - Günthard, H. F.
AU - Ledergerber, Bruno
AU - Fellay, Jacques
AU - Burkhalter, Felix
AU - Tarr, P.
AU - Swiss HIV Cohort Study (SHCS)
N1 - Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023
Y1 - 2023
N2 - Background: Bone mineral density (BMD) loss may be accelerated in people with HIV (PLWH). It is unknown whether a polygenic risk score (PRS) is associated with low BMD in PLWH. Methods: Swiss HIV Cohort Study participants of self-reported European descent underwent ≥2 per-protocol dual x-ray absorptiometry (DXA) measurements ≥2 years apart (2011-2020). Univariable and multivariable odds ratios (ORs) for DXA-defined osteoporosis were based on traditional and HIV-related risk factors and a genome-wide PRS built from 9413 single-nucleotide polymorphisms associated with low BMD in the general population. Controls were free from osteoporosis/osteopenia on all DXA measurements. Results: We included 438 participants: 149 with osteoporosis and 289 controls (median age, 53 years; 82% male, 95% with suppressed HIV RNA). Participants with unfavorable osteoporosis PRS (top vs bottom quintile) had univariable and multivariable-adjusted osteoporosis ORs of 4.76 (95% CI, 2.34-9.67) and 4.13 (1.86-9.18), respectively. For comparison, hepatitis C seropositivity, 5-year tenofovir disoproxil fumarate exposure, and parent history of hip fracture yielded univariable osteoporosis ORs of 2.26 (1.37-3.74), 1.84 (1.40-2.43), and 1.54 (0.82-2.9). Conclusions: In PLWH in Switzerland, osteoporosis was independently associated with a BMD-associated PRS after adjustment for established risk factors, including exposure to tenofovir disoproxil fumarate.
AB - Background: Bone mineral density (BMD) loss may be accelerated in people with HIV (PLWH). It is unknown whether a polygenic risk score (PRS) is associated with low BMD in PLWH. Methods: Swiss HIV Cohort Study participants of self-reported European descent underwent ≥2 per-protocol dual x-ray absorptiometry (DXA) measurements ≥2 years apart (2011-2020). Univariable and multivariable odds ratios (ORs) for DXA-defined osteoporosis were based on traditional and HIV-related risk factors and a genome-wide PRS built from 9413 single-nucleotide polymorphisms associated with low BMD in the general population. Controls were free from osteoporosis/osteopenia on all DXA measurements. Results: We included 438 participants: 149 with osteoporosis and 289 controls (median age, 53 years; 82% male, 95% with suppressed HIV RNA). Participants with unfavorable osteoporosis PRS (top vs bottom quintile) had univariable and multivariable-adjusted osteoporosis ORs of 4.76 (95% CI, 2.34-9.67) and 4.13 (1.86-9.18), respectively. For comparison, hepatitis C seropositivity, 5-year tenofovir disoproxil fumarate exposure, and parent history of hip fracture yielded univariable osteoporosis ORs of 2.26 (1.37-3.74), 1.84 (1.40-2.43), and 1.54 (0.82-2.9). Conclusions: In PLWH in Switzerland, osteoporosis was independently associated with a BMD-associated PRS after adjustment for established risk factors, including exposure to tenofovir disoproxil fumarate.
KW - aging
KW - HIV infection
KW - low bone mineral density
KW - osteoporosis
KW - polygenic risk score
U2 - 10.1093/infdis/jiad179
DO - 10.1093/infdis/jiad179
M3 - Journal article
C2 - 37225667
AN - SCOPUS:85173444253
VL - 228
SP - 742
EP - 750
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 6
ER -
ID: 397033385