Association between sugar intake and intima media thickness as a marker for atherosclerosis: A cross-sectional study in the Malmö diet and cancer study (Sweden)
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Association between sugar intake and intima media thickness as a marker for atherosclerosis : A cross-sectional study in the Malmö diet and cancer study (Sweden). / González-Padilla, Esther; Janzi, Suzanne; Ramne, Stina; Thuneland, Camilla; Borné, Yan; Sonestedt, Emily.
I: Nutrients, Bind 13, Nr. 5, 1555, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association between sugar intake and intima media thickness as a marker for atherosclerosis
T2 - A cross-sectional study in the Malmö diet and cancer study (Sweden)
AU - González-Padilla, Esther
AU - Janzi, Suzanne
AU - Ramne, Stina
AU - Thuneland, Camilla
AU - Borné, Yan
AU - Sonestedt, Emily
N1 - Funding Information: Funding: This research was funded by the Swedish Research Council (2016-01501), the Heart and Lung Foundation (2016-0267, 2019-0555) and the Albert Påhlsson Foundation. Further support was provided by the Swedish Foundation for Strategic Research (IRC15-006). The APC was funded by Lund University’s APC Fund. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - It has been suggested that sugar intake may play a role in the development of atherosclero-sis. However, studies on this matter are lacking. Intima media thickness (IMT) is a well-established measurement of subclinical atherosclerosis. This study aimed to investigate the cross-sectional association between sugar intake (i.e., added, free and total sugar and sugar-rich foods and beverages) and IMT. Our study comprised 5269 individuals (45–73 years, 40% men) of the Malmö Diet and Cancer Study, a population-based cohort conducted in Sweden with data collected from 1991 to 1994. Measurements of IMT were performed with B-mode ultrasound at the right common carotid artery (IMTcca) and the bifurcation of the carotids (IMTbif). Dietary intake was estimated using a combina-tion of a 7-day food record, diet questionnaire and interview. After adjusting for methodological, lifestyle and dietary confounders, no statistically significant associations were observed for any of the sugar intake variables and IMT. For example, added sugar intake presented no significant linear association with IMTcca or IMTbif (Ptrends: IMTcca 0.81 for men and 0.98 for women and IMTbif 0.20 for men and 0.40 for women). In conclusion, we found no clear association between sugar intake and IMT measurements in this study.
AB - It has been suggested that sugar intake may play a role in the development of atherosclero-sis. However, studies on this matter are lacking. Intima media thickness (IMT) is a well-established measurement of subclinical atherosclerosis. This study aimed to investigate the cross-sectional association between sugar intake (i.e., added, free and total sugar and sugar-rich foods and beverages) and IMT. Our study comprised 5269 individuals (45–73 years, 40% men) of the Malmö Diet and Cancer Study, a population-based cohort conducted in Sweden with data collected from 1991 to 1994. Measurements of IMT were performed with B-mode ultrasound at the right common carotid artery (IMTcca) and the bifurcation of the carotids (IMTbif). Dietary intake was estimated using a combina-tion of a 7-day food record, diet questionnaire and interview. After adjusting for methodological, lifestyle and dietary confounders, no statistically significant associations were observed for any of the sugar intake variables and IMT. For example, added sugar intake presented no significant linear association with IMTcca or IMTbif (Ptrends: IMTcca 0.81 for men and 0.98 for women and IMTbif 0.20 for men and 0.40 for women). In conclusion, we found no clear association between sugar intake and IMT measurements in this study.
KW - Added sugar
KW - Atherosclerosis
KW - Free sugar
KW - IMT
KW - Intima media thickness
KW - SSB
KW - Sugar intake
KW - Sugar-rich foods
KW - Sugar-sweetened beverages
KW - Total sugar
U2 - 10.3390/nu13051555
DO - 10.3390/nu13051555
M3 - Journal article
C2 - 34063058
AN - SCOPUS:85105222712
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 5
M1 - 1555
ER -
ID: 288801614