Association between atopic dermatitis and hypertension: a systematic review and meta-analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Association between atopic dermatitis and hypertension : a systematic review and meta-analysis. / Yousaf, M.; Ayasse, M.; Ahmed, A.; Gwillim, E. C.; Janmohamed, S. R.; Yousaf, A.; Patel, K. R.; Thyssen, J. P.; Silverberg, J. I.
I: British Journal of Dermatology, Bind 186, Nr. 2, 2022, s. 227-235.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association between atopic dermatitis and hypertension
T2 - a systematic review and meta-analysis
AU - Yousaf, M.
AU - Ayasse, M.
AU - Ahmed, A.
AU - Gwillim, E. C.
AU - Janmohamed, S. R.
AU - Yousaf, A.
AU - Patel, K. R.
AU - Thyssen, J. P.
AU - Silverberg, J. I.
N1 - Publisher Copyright: © 2021 British Association of Dermatologists
PY - 2022
Y1 - 2022
N2 - Background: Previous studies have found conflicting results about the association of atopic dermatitis (AD) with hypertension. Objectives: To determine whether AD and AD severity are associated with hypertension. Methods: A systematic review was performed of published studies in Ovid MEDLINE, Embase, Scopus, Web of Science, and GREAT (Global Resource for EczemA Trials) databases. At least two reviewers conducted title/abstract, full-text review and data extraction. Quality of evidence was assessed using the Newcastle–Ottawa Scale. Results: Fifty-one studies met the inclusion criteria and 19 had sufficient data for meta-analysis. AD was associated with higher odds of hypertension compared with healthy controls [increased in nine of 16 studies; pooled prevalence 16·4% vs. 13·8%; random-effects regression, pooled unadjusted odds ratio (OR) 1·16, 95% confidence interval (CI) 1·04–1·30], but lower odds of hypertension compared with psoriasis [decreased in five of eight studies; 15·4% vs. 24·8% (OR 0·53, 95% CI 0·37–0·76)]. In particular, moderate-to-severe AD was associated with hypertension compared with healthy controls [increased in four of six studies; 24·9% vs. 14·7% (OR 2·33, 95% CI 1·10–4·94)]. Hypertension was commonly reported as an adverse event secondary to AD treatments, particularly systemic ciclosporin A. Limitations include lack of longitudinal studies or individual-level data, and potential confounding. Conclusions: AD, particularly moderate-to-severe disease, was associated with increased hypertension compared with healthy controls, but with lower odds than for psoriasis.
AB - Background: Previous studies have found conflicting results about the association of atopic dermatitis (AD) with hypertension. Objectives: To determine whether AD and AD severity are associated with hypertension. Methods: A systematic review was performed of published studies in Ovid MEDLINE, Embase, Scopus, Web of Science, and GREAT (Global Resource for EczemA Trials) databases. At least two reviewers conducted title/abstract, full-text review and data extraction. Quality of evidence was assessed using the Newcastle–Ottawa Scale. Results: Fifty-one studies met the inclusion criteria and 19 had sufficient data for meta-analysis. AD was associated with higher odds of hypertension compared with healthy controls [increased in nine of 16 studies; pooled prevalence 16·4% vs. 13·8%; random-effects regression, pooled unadjusted odds ratio (OR) 1·16, 95% confidence interval (CI) 1·04–1·30], but lower odds of hypertension compared with psoriasis [decreased in five of eight studies; 15·4% vs. 24·8% (OR 0·53, 95% CI 0·37–0·76)]. In particular, moderate-to-severe AD was associated with hypertension compared with healthy controls [increased in four of six studies; 24·9% vs. 14·7% (OR 2·33, 95% CI 1·10–4·94)]. Hypertension was commonly reported as an adverse event secondary to AD treatments, particularly systemic ciclosporin A. Limitations include lack of longitudinal studies or individual-level data, and potential confounding. Conclusions: AD, particularly moderate-to-severe disease, was associated with increased hypertension compared with healthy controls, but with lower odds than for psoriasis.
U2 - 10.1111/bjd.20661
DO - 10.1111/bjd.20661
M3 - Review
C2 - 34319589
AN - SCOPUS:85115950401
VL - 186
SP - 227
EP - 235
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 2
ER -
ID: 316681759