Arrhythmia mechanism dependent pulmonary vein ablation in paroxysmal atrial fibrillation

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Standard

Arrhythmia mechanism dependent pulmonary vein ablation in paroxysmal atrial fibrillation. / Gottlieb, Lisa A; Dekker, Lukas R C; Coronel, Ruben.

I: Frontiers in Physiology, Bind 14, 1157338, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gottlieb, LA, Dekker, LRC & Coronel, R 2023, 'Arrhythmia mechanism dependent pulmonary vein ablation in paroxysmal atrial fibrillation', Frontiers in Physiology, bind 14, 1157338. https://doi.org/10.3389/fphys.2023.1157338

APA

Gottlieb, L. A., Dekker, L. R. C., & Coronel, R. (2023). Arrhythmia mechanism dependent pulmonary vein ablation in paroxysmal atrial fibrillation. Frontiers in Physiology, 14, [1157338]. https://doi.org/10.3389/fphys.2023.1157338

Vancouver

Gottlieb LA, Dekker LRC, Coronel R. Arrhythmia mechanism dependent pulmonary vein ablation in paroxysmal atrial fibrillation. Frontiers in Physiology. 2023;14. 1157338. https://doi.org/10.3389/fphys.2023.1157338

Author

Gottlieb, Lisa A ; Dekker, Lukas R C ; Coronel, Ruben. / Arrhythmia mechanism dependent pulmonary vein ablation in paroxysmal atrial fibrillation. I: Frontiers in Physiology. 2023 ; Bind 14.

Bibtex

@article{0c53030d8b3945b6824840f56359f55e,

title = "Arrhythmia mechanism dependent pulmonary vein ablation in paroxysmal atrial fibrillation",

abstract = "Atrial fibrillation (AF) often requires invasive treatment by ablation to decrease symptom burden. The pulmonary veins (PV) are thought to trigger paroxysms of AF, and ablative PV isolation (PVI) is a cornerstone in AF treatment. However, incomplete PVI, where electrical conduction between the PV and left atrium (LA) is maintained, is curative of AF in a subset of patients. This implies that an antiarrhythmic effect other than electrical isolation between the PV and LA plays a role in AF prevention in these patients. We reason that the PV myocardium constitutes an arrhythmogenic substrate conducive to reentry in the patients with curative incomplete PVI. This PV substrate is amenable to ablation, even when conduction between the LA and PV persists. We propose that PV ablation strategies are differentiated to fit the arrhythmogenic mechanisms in the individual patient. PV substrate modification in patients with PV reentry may constitute a new therapeutic approach that is potentially simpler and more effective, in this subgroup of patients.",

author = "Gottlieb, {Lisa A} and Dekker, {Lukas R C} and Ruben Coronel",

note = "Copyright {\textcopyright} 2023 Gottlieb, Dekker and Coronel.",

year = "2023",

doi = "10.3389/fphys.2023.1157338",

language = "English",

volume = "14",

journal = "Frontiers in Physiology",

issn = "1664-042X",

publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Arrhythmia mechanism dependent pulmonary vein ablation in paroxysmal atrial fibrillation

AU - Gottlieb, Lisa A

AU - Dekker, Lukas R C

AU - Coronel, Ruben

PY - 2023

Y1 - 2023

N2 - Atrial fibrillation (AF) often requires invasive treatment by ablation to decrease symptom burden. The pulmonary veins (PV) are thought to trigger paroxysms of AF, and ablative PV isolation (PVI) is a cornerstone in AF treatment. However, incomplete PVI, where electrical conduction between the PV and left atrium (LA) is maintained, is curative of AF in a subset of patients. This implies that an antiarrhythmic effect other than electrical isolation between the PV and LA plays a role in AF prevention in these patients. We reason that the PV myocardium constitutes an arrhythmogenic substrate conducive to reentry in the patients with curative incomplete PVI. This PV substrate is amenable to ablation, even when conduction between the LA and PV persists. We propose that PV ablation strategies are differentiated to fit the arrhythmogenic mechanisms in the individual patient. PV substrate modification in patients with PV reentry may constitute a new therapeutic approach that is potentially simpler and more effective, in this subgroup of patients.

AB - Atrial fibrillation (AF) often requires invasive treatment by ablation to decrease symptom burden. The pulmonary veins (PV) are thought to trigger paroxysms of AF, and ablative PV isolation (PVI) is a cornerstone in AF treatment. However, incomplete PVI, where electrical conduction between the PV and left atrium (LA) is maintained, is curative of AF in a subset of patients. This implies that an antiarrhythmic effect other than electrical isolation between the PV and LA plays a role in AF prevention in these patients. We reason that the PV myocardium constitutes an arrhythmogenic substrate conducive to reentry in the patients with curative incomplete PVI. This PV substrate is amenable to ablation, even when conduction between the LA and PV persists. We propose that PV ablation strategies are differentiated to fit the arrhythmogenic mechanisms in the individual patient. PV substrate modification in patients with PV reentry may constitute a new therapeutic approach that is potentially simpler and more effective, in this subgroup of patients.

U2 - 10.3389/fphys.2023.1157338

DO - 10.3389/fphys.2023.1157338

M3 - Journal article

C2 - 37293260

VL - 14

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 1157338

ER -

ID: 396849603