Apelin is a novel islet peptide

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Apelin is a novel islet peptide. / Ringström, Camilla; Nitert, Marloes Dekker; Bennet, Hedvig; Fex, Malin; Valet, Philippe; Rehfeld, Jens F.; Friis-Hansen, Lennart Jan; Wierup, Nils.

I: Regulatory Peptides, Bind 162, Nr. 1-3, 08.06.2010, s. 44-51.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ringström, C, Nitert, MD, Bennet, H, Fex, M, Valet, P, Rehfeld, JF, Friis-Hansen, LJ & Wierup, N 2010, 'Apelin is a novel islet peptide', Regulatory Peptides, bind 162, nr. 1-3, s. 44-51. https://doi.org/10.1016/j.regpep.2010.03.005

APA

Ringström, C., Nitert, M. D., Bennet, H., Fex, M., Valet, P., Rehfeld, J. F., Friis-Hansen, L. J., & Wierup, N. (2010). Apelin is a novel islet peptide. Regulatory Peptides, 162(1-3), 44-51. https://doi.org/10.1016/j.regpep.2010.03.005

Vancouver

Ringström C, Nitert MD, Bennet H, Fex M, Valet P, Rehfeld JF o.a. Apelin is a novel islet peptide. Regulatory Peptides. 2010 jun. 8;162(1-3):44-51. https://doi.org/10.1016/j.regpep.2010.03.005

Author

Ringström, Camilla ; Nitert, Marloes Dekker ; Bennet, Hedvig ; Fex, Malin ; Valet, Philippe ; Rehfeld, Jens F. ; Friis-Hansen, Lennart Jan ; Wierup, Nils. / Apelin is a novel islet peptide. I: Regulatory Peptides. 2010 ; Bind 162, Nr. 1-3. s. 44-51.

Bibtex

@article{56a996e4f4c44633841f46d73e0be197,

title = "Apelin is a novel islet peptide",

abstract = "Apelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion. We examined whether apelin is expressed in human islets, as well as in normal and type 2 diabetic (T2D) animal islets. Further, we studied islet apelin regulation and the effect of apelin on insulin secretion. Apelin expression and regulation was examined in human and animal specimens using immunocytochemistry, in situ hybridization, and real-time PCR. Insulin secretion was studied in INS-1 (832/13) clonal beta cells. APJ-receptor expression was studied using real-time PCR. In human and murine islets apelin was predominantly expressed in beta cells and alpha cells; a subpopulation of the PP cells in human islets also harbored apelin. In porcine and feline islets apelin was mainly expressed in beta cells. APJ-receptor expression was detected in INS-1 (832/13) cells, and in human and mouse islets. A high dose (1microM) of apelin-36 caused a moderate increase in glucose-stimulated insulin secretion (30%; p",

author = "Camilla Ringstr{\"o}m and Nitert, {Marloes Dekker} and Hedvig Bennet and Malin Fex and Philippe Valet and Rehfeld, {Jens F.} and Friis-Hansen, {Lennart Jan} and Nils Wierup",

year = "2010",

month = jun,

day = "8",

doi = "http://dx.doi.org/10.1016/j.regpep.2010.03.005",

language = "English",

volume = "162",

pages = "44--51",

journal = "Regulatory Peptides",

issn = "0167-0115",

publisher = "Elsevier",

number = "1-3",

}

RIS

TY - JOUR

T1 - Apelin is a novel islet peptide

AU - Ringström, Camilla

AU - Nitert, Marloes Dekker

AU - Bennet, Hedvig

AU - Fex, Malin

AU - Valet, Philippe

AU - Rehfeld, Jens F.

AU - Friis-Hansen, Lennart Jan

AU - Wierup, Nils

PY - 2010/6/8

Y1 - 2010/6/8

N2 - Apelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion. We examined whether apelin is expressed in human islets, as well as in normal and type 2 diabetic (T2D) animal islets. Further, we studied islet apelin regulation and the effect of apelin on insulin secretion. Apelin expression and regulation was examined in human and animal specimens using immunocytochemistry, in situ hybridization, and real-time PCR. Insulin secretion was studied in INS-1 (832/13) clonal beta cells. APJ-receptor expression was studied using real-time PCR. In human and murine islets apelin was predominantly expressed in beta cells and alpha cells; a subpopulation of the PP cells in human islets also harbored apelin. In porcine and feline islets apelin was mainly expressed in beta cells. APJ-receptor expression was detected in INS-1 (832/13) cells, and in human and mouse islets. A high dose (1microM) of apelin-36 caused a moderate increase in glucose-stimulated insulin secretion (30%; p

AB - Apelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion. We examined whether apelin is expressed in human islets, as well as in normal and type 2 diabetic (T2D) animal islets. Further, we studied islet apelin regulation and the effect of apelin on insulin secretion. Apelin expression and regulation was examined in human and animal specimens using immunocytochemistry, in situ hybridization, and real-time PCR. Insulin secretion was studied in INS-1 (832/13) clonal beta cells. APJ-receptor expression was studied using real-time PCR. In human and murine islets apelin was predominantly expressed in beta cells and alpha cells; a subpopulation of the PP cells in human islets also harbored apelin. In porcine and feline islets apelin was mainly expressed in beta cells. APJ-receptor expression was detected in INS-1 (832/13) cells, and in human and mouse islets. A high dose (1microM) of apelin-36 caused a moderate increase in glucose-stimulated insulin secretion (30%; p

U2 - http://dx.doi.org/10.1016/j.regpep.2010.03.005

DO - http://dx.doi.org/10.1016/j.regpep.2010.03.005

M3 - Journal article

VL - 162

SP - 44

EP - 51

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 1-3

ER -

ID: 34179609