Annexin A7 mediates lysosome repair independently of ESCRT-III
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Lysosomes are crucial organelles essential for various cellular processes, and any damage to them can severely compromise cell viability. This study uncovers a previously unrecognized function of the calcium- and phospholipid-binding protein Annexin A7 in lysosome repair, which operates independently of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery. Our research reveals that Annexin A7 plays a role in repairing damaged lysosomes, different from its role in repairing the plasma membrane, where it facilitates repair through the recruitment of ESCRT-III components. Notably, our findings strongly suggest that Annexin A7, like the ESCRT machinery, is dispensable for membrane contact site formation within the newly discovered phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway. Instead, we speculate that Annexin A7 is recruited to damaged lysosomes and promotes repair through its membrane curvature and cross-linking capabilities. Our findings provide new insights into the diverse mechanisms underlying lysosomal membrane repair and highlight the multifunctional role of Annexin A7 in membrane repair.
Originalsprog | Engelsk |
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Artikelnummer | 1211498 |
Tidsskrift | Frontiers in Cell and Developmental Biology |
Vol/bind | 11 |
Antal sider | 19 |
ISSN | 2296-634X |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
This study was supported by the Scientific Committee Danish Cancer Society (R90-A5847-14-S2, R269-A15812), the Danish Council for Independent Research (6108-00378A, 9040-00252B), and the Novo Nordisk Foundation (NNF18OC0034936).
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Copyright © 2024 Ebstrup, Sønder, Fogde, Heitmann, Dietrich, Dias, Jäättelä, Maeda and Nylandsted.
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