Anatomical patterns of dermatitis in adult filaggrin mutation carriers
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Anatomical patterns of dermatitis in adult filaggrin mutation carriers. / Heede, Nina G; Thyssen, Jacob Pontoppidan; Thuesen, Betina H; Linneberg, Allan René; Johansen, Jeanne Duus.
I: Journal of the American Academy of Dermatology, Bind 72, Nr. 3, 03.2015, s. 440-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Anatomical patterns of dermatitis in adult filaggrin mutation carriers
AU - Heede, Nina G
AU - Thyssen, Jacob Pontoppidan
AU - Thuesen, Betina H
AU - Linneberg, Allan René
AU - Johansen, Jeanne Duus
N1 - Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
PY - 2015/3
Y1 - 2015/3
N2 - BACKGROUND: Common filaggrin (FLG) null mutations are associated with severe and early onset of atopic dermatitis (AD). To date, few studies have investigated anatomical patterns of dermatitis and none has been conducted in the general population.OBJECTIVE: We evaluated patterns of dermatitis in an adult general population stratified by FLG genotype.METHODS: Data from a population-based cohort study with a 5-year follow-up were used. This study included 2143 participants aged 18 to 72 years. Information about dermatitis on the hands; feet; face; axillae; and abdomen, chest, or back was obtained by use of questionnaires. Participants were genotyped for common FLG mutations. A history of AD was defined by the United Kingdom Working Party's diagnostic criteria.RESULTS: The frequency of foot dermatitis in the general population was associated with FLG genotype (P = .014). However, when stratification of FLG genotype and AD was performed, we found that FLG mutations increased the prevalence (odds ratios) of foot dermatitis (odds ratio 10.41; 95% confidence interval 5.27-20.60) and persistent hand dermatitis (odds ratio 17.57; 95% confidence interval 8.60-35.89) only in participants with AD.LIMITATIONS: Potential misclassification and recall bias are study limitations.CONCLUSION: FLG mutations affected the lifetime prevalence of hand and foot dermatitis in participants with a history of AD.
AB - BACKGROUND: Common filaggrin (FLG) null mutations are associated with severe and early onset of atopic dermatitis (AD). To date, few studies have investigated anatomical patterns of dermatitis and none has been conducted in the general population.OBJECTIVE: We evaluated patterns of dermatitis in an adult general population stratified by FLG genotype.METHODS: Data from a population-based cohort study with a 5-year follow-up were used. This study included 2143 participants aged 18 to 72 years. Information about dermatitis on the hands; feet; face; axillae; and abdomen, chest, or back was obtained by use of questionnaires. Participants were genotyped for common FLG mutations. A history of AD was defined by the United Kingdom Working Party's diagnostic criteria.RESULTS: The frequency of foot dermatitis in the general population was associated with FLG genotype (P = .014). However, when stratification of FLG genotype and AD was performed, we found that FLG mutations increased the prevalence (odds ratios) of foot dermatitis (odds ratio 10.41; 95% confidence interval 5.27-20.60) and persistent hand dermatitis (odds ratio 17.57; 95% confidence interval 8.60-35.89) only in participants with AD.LIMITATIONS: Potential misclassification and recall bias are study limitations.CONCLUSION: FLG mutations affected the lifetime prevalence of hand and foot dermatitis in participants with a history of AD.
KW - Adolescent
KW - Adult
KW - Aged
KW - Cohort Studies
KW - Dermatitis, Atopic
KW - Female
KW - Genotype
KW - Humans
KW - Intermediate Filament Proteins
KW - Male
KW - Middle Aged
KW - Mutation
KW - Young Adult
U2 - 10.1016/j.jaad.2015.01.001
DO - 10.1016/j.jaad.2015.01.001
M3 - Journal article
C2 - 25659224
VL - 72
SP - 440
EP - 448
JO - American Academy of Dermatology. Journal
JF - American Academy of Dermatology. Journal
SN - 0190-9622
IS - 3
ER -
ID: 161847402