An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells

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An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells. / Heldager Pedersen, Nanna; Bjerregaard Jeppesen, Helene; Persson, Gry; Bojesen, Sophie; Hviid, Thomas Vauvert F.

I: Current Research in Immunology, Bind 5, 100074, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Heldager Pedersen, N, Bjerregaard Jeppesen, H, Persson, G, Bojesen, S & Hviid, TVF 2024, 'An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells', Current Research in Immunology, bind 5, 100074. https://doi.org/10.1016/j.crimmu.2023.100074

APA

Heldager Pedersen, N., Bjerregaard Jeppesen, H., Persson, G., Bojesen, S., & Hviid, T. V. F. (2024). An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells. Current Research in Immunology, 5, [100074]. https://doi.org/10.1016/j.crimmu.2023.100074

Vancouver

Heldager Pedersen N, Bjerregaard Jeppesen H, Persson G, Bojesen S, Hviid TVF. An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells. Current Research in Immunology. 2024;5. 100074. https://doi.org/10.1016/j.crimmu.2023.100074

Author

Heldager Pedersen, Nanna ; Bjerregaard Jeppesen, Helene ; Persson, Gry ; Bojesen, Sophie ; Hviid, Thomas Vauvert F. / An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells. I: Current Research in Immunology. 2024 ; Bind 5.

Bibtex

@article{25c8daaf12d04327ba3fec7f2a997d1f,

title = "An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells",

abstract = "Malignant melanoma is a highly immunogenic tumour, and the immune profile significantly influences cancer development and response to immunotherapy. The peripheral immune profile may identify high risk patients. The current study showed reduced levels of CD4+ T cells and increased levels of CD8+ T cells in peripheral blood from malignant melanoma patients compared with controls. Percentages of peripheral CD56dimCD16+ NK cells were reduced and CD56brightCD16−KIR3+ NK cells were increased in malignant melanoma patients. Late stage malignant melanoma was correlated with low levels of CD4+ T cells and high levels of CD56brightCD16−KIR3+ NK cells. Finally, high levels of Tregs in peripheral blood were correlated with poor overall survival and disease-free survival. The results indicate that changes in specific immune cell subsets in peripheral blood samples from patients at the time of diagnosis may be potential biomarkers for prognosis and survival. Further studies will enable clarification of independent roles in tumour pathogenesis.",

keywords = "Immune marker, Malignant melanoma, NK cell, Survival, T cell",

author = "{Heldager Pedersen}, Nanna and {Bjerregaard Jeppesen}, Helene and Gry Persson and Sophie Bojesen and Hviid, {Thomas Vauvert F.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2024",

doi = "10.1016/j.crimmu.2023.100074",

language = "English",

volume = "5",

journal = "Current Research in Immunology",

issn = "2590-2555",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells

AU - Heldager Pedersen, Nanna

AU - Bjerregaard Jeppesen, Helene

AU - Persson, Gry

AU - Bojesen, Sophie

AU - Hviid, Thomas Vauvert F.

PY - 2024

Y1 - 2024

N2 - Malignant melanoma is a highly immunogenic tumour, and the immune profile significantly influences cancer development and response to immunotherapy. The peripheral immune profile may identify high risk patients. The current study showed reduced levels of CD4+ T cells and increased levels of CD8+ T cells in peripheral blood from malignant melanoma patients compared with controls. Percentages of peripheral CD56dimCD16+ NK cells were reduced and CD56brightCD16−KIR3+ NK cells were increased in malignant melanoma patients. Late stage malignant melanoma was correlated with low levels of CD4+ T cells and high levels of CD56brightCD16−KIR3+ NK cells. Finally, high levels of Tregs in peripheral blood were correlated with poor overall survival and disease-free survival. The results indicate that changes in specific immune cell subsets in peripheral blood samples from patients at the time of diagnosis may be potential biomarkers for prognosis and survival. Further studies will enable clarification of independent roles in tumour pathogenesis.

AB - Malignant melanoma is a highly immunogenic tumour, and the immune profile significantly influences cancer development and response to immunotherapy. The peripheral immune profile may identify high risk patients. The current study showed reduced levels of CD4+ T cells and increased levels of CD8+ T cells in peripheral blood from malignant melanoma patients compared with controls. Percentages of peripheral CD56dimCD16+ NK cells were reduced and CD56brightCD16−KIR3+ NK cells were increased in malignant melanoma patients. Late stage malignant melanoma was correlated with low levels of CD4+ T cells and high levels of CD56brightCD16−KIR3+ NK cells. Finally, high levels of Tregs in peripheral blood were correlated with poor overall survival and disease-free survival. The results indicate that changes in specific immune cell subsets in peripheral blood samples from patients at the time of diagnosis may be potential biomarkers for prognosis and survival. Further studies will enable clarification of independent roles in tumour pathogenesis.

KW - Immune marker

KW - Malignant melanoma

KW - NK cell

KW - Survival

KW - T cell

U2 - 10.1016/j.crimmu.2023.100074

DO - 10.1016/j.crimmu.2023.100074

M3 - Journal article

C2 - 38059204

AN - SCOPUS:85178128077

VL - 5

JO - Current Research in Immunology

JF - Current Research in Immunology

SN - 2590-2555

M1 - 100074

ER -

ID: 381066943