Alignment of Transcatheter Aortic-Valve Neo-Commissures (ALIGN TAVR): Impact on Final Valve Orientation and Coronary Artery Overlap
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Alignment of Transcatheter Aortic-Valve Neo-Commissures (ALIGN TAVR) : Impact on Final Valve Orientation and Coronary Artery Overlap. / Tang, Gilbert H.L.; Zaid, Syed; Fuchs, Andreas; Yamabe, Tsuyoshi; Yazdchi, Farhang; Gupta, Eisha; Ahmad, Hasan; Kofoed, Klaus F.; Goldberg, Joshua B.; Undemir, Cenap; Kaple, Ryan K.; Shah, Pinak B.; Kaneko, Tsuyoshi; Lansman, Steven L.; Khera, Sahil; Kovacic, Jason C.; Dangas, George D.; Lerakis, Stamatios; Sharma, Samin K.; Kini, Annapoorna; Adams, David H.; Khalique, Omar K.; Hahn, Rebecca T.; Søndergaard, Lars; George, Isaac; Kodali, Susheel K.; De Backer, Ole; Leon, Martin B.; Bapat, Vinayak N.
I: JACC: Cardiovascular Interventions, Bind 13, Nr. 9, 2020, s. 1030-1042.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Alignment of Transcatheter Aortic-Valve Neo-Commissures (ALIGN TAVR)
T2 - Impact on Final Valve Orientation and Coronary Artery Overlap
AU - Tang, Gilbert H.L.
AU - Zaid, Syed
AU - Fuchs, Andreas
AU - Yamabe, Tsuyoshi
AU - Yazdchi, Farhang
AU - Gupta, Eisha
AU - Ahmad, Hasan
AU - Kofoed, Klaus F.
AU - Goldberg, Joshua B.
AU - Undemir, Cenap
AU - Kaple, Ryan K.
AU - Shah, Pinak B.
AU - Kaneko, Tsuyoshi
AU - Lansman, Steven L.
AU - Khera, Sahil
AU - Kovacic, Jason C.
AU - Dangas, George D.
AU - Lerakis, Stamatios
AU - Sharma, Samin K.
AU - Kini, Annapoorna
AU - Adams, David H.
AU - Khalique, Omar K.
AU - Hahn, Rebecca T.
AU - Søndergaard, Lars
AU - George, Isaac
AU - Kodali, Susheel K.
AU - De Backer, Ole
AU - Leon, Martin B.
AU - Bapat, Vinayak N.
PY - 2020
Y1 - 2020
N2 - Objectives: The aim of this study was to evaluate the impact of initial deployment orientation of SAPIEN 3, Evolut, and ACURATE-neo transcatheter heart valves on their final orientation and neocommissural overlap with coronary arteries. Background: Coronary artery access and redo transcatheter aortic valve replacement (TAVR) following initial TAVR may be influenced by transcatheter heart valve orientation. In this study the impact of transcatheter heart valve deployment orientation on commissural alignment was evaluated. Methods: Pre-TAVR computed tomography and procedural fluoroscopy were analyzed in 828 patients who underwent TAVR (483 SAPIEN 3, 245 Evolut, and 100 ACURATE-neo valves) from March 2016 to September 2019 at 5 centers. Coplanar fluoroscopic views were coregistered to pre-TAVR computed tomography to determine commissural alignment. Severe overlap between neocommissural posts and coronary arteries was defined as 0° to 20° apart. The SAPIEN 3 had 1 commissural post crimped at 3, 6, 9, and 12 o'clock. The Evolut “Hat” marker and ACURATE-neo commissural post at deployment were classified as center back (CB), inner curve (IC), outer curve (OC), or center front (CF) and matched with final orientation. Results: Initial SAPIEN 3 crimped orientation had no impact on commissural alignment. Evolut “Hat” at OC or CF at initial deployment had less severe overlap than IC or CB (p < 0.001) against the left main (15.7% vs. 66.0%) and right coronary (7.1% vs. 51.1%) arteries. Tracking Evolut “Hat” at OC of the descending aorta (n = 107) improved OC at deployment from 70.2% to 91.6% (p = 0.002) and reduced coronary artery overlap by 36% to 60% (p < 0.05). ACURATE-neo commissural post at CB or IC during deployment had less coronary artery overlap compared to CF or OC (p < 0.001), with intentional alignment successful in 5 of 7 cases. Conclusions: This is the first systematic evaluation of commissural alignment in TAVR. More than 30% to 50% of cases had overlap with 1 or both coronary arteries. Initial SAPIEN 3 orientation had no impact on alignment, but specific initial orientations of Evolut and ACURATE improved alignment. Optimizing valve alignment to avoid coronary artery overlap will be important in coronary artery access and redo TAVR.
AB - Objectives: The aim of this study was to evaluate the impact of initial deployment orientation of SAPIEN 3, Evolut, and ACURATE-neo transcatheter heart valves on their final orientation and neocommissural overlap with coronary arteries. Background: Coronary artery access and redo transcatheter aortic valve replacement (TAVR) following initial TAVR may be influenced by transcatheter heart valve orientation. In this study the impact of transcatheter heart valve deployment orientation on commissural alignment was evaluated. Methods: Pre-TAVR computed tomography and procedural fluoroscopy were analyzed in 828 patients who underwent TAVR (483 SAPIEN 3, 245 Evolut, and 100 ACURATE-neo valves) from March 2016 to September 2019 at 5 centers. Coplanar fluoroscopic views were coregistered to pre-TAVR computed tomography to determine commissural alignment. Severe overlap between neocommissural posts and coronary arteries was defined as 0° to 20° apart. The SAPIEN 3 had 1 commissural post crimped at 3, 6, 9, and 12 o'clock. The Evolut “Hat” marker and ACURATE-neo commissural post at deployment were classified as center back (CB), inner curve (IC), outer curve (OC), or center front (CF) and matched with final orientation. Results: Initial SAPIEN 3 crimped orientation had no impact on commissural alignment. Evolut “Hat” at OC or CF at initial deployment had less severe overlap than IC or CB (p < 0.001) against the left main (15.7% vs. 66.0%) and right coronary (7.1% vs. 51.1%) arteries. Tracking Evolut “Hat” at OC of the descending aorta (n = 107) improved OC at deployment from 70.2% to 91.6% (p = 0.002) and reduced coronary artery overlap by 36% to 60% (p < 0.05). ACURATE-neo commissural post at CB or IC during deployment had less coronary artery overlap compared to CF or OC (p < 0.001), with intentional alignment successful in 5 of 7 cases. Conclusions: This is the first systematic evaluation of commissural alignment in TAVR. More than 30% to 50% of cases had overlap with 1 or both coronary arteries. Initial SAPIEN 3 orientation had no impact on alignment, but specific initial orientations of Evolut and ACURATE improved alignment. Optimizing valve alignment to avoid coronary artery overlap will be important in coronary artery access and redo TAVR.
KW - commissural alignment
KW - coronary artery access
KW - transcatheter aortic valve replacement
U2 - 10.1016/j.jcin.2020.02.005
DO - 10.1016/j.jcin.2020.02.005
M3 - Journal article
C2 - 32192985
AN - SCOPUS:85083703977
VL - 13
SP - 1030
EP - 1042
JO - J A C C: Cardiovascular Interventions
JF - J A C C: Cardiovascular Interventions
SN - 1936-8798
IS - 9
ER -
ID: 260597460