Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Neuropeptide Y (NPY) gene transduction of the brain using viral vectors in epileptogenic regions can effectively suppress seizures in animals, and is being considered as a promising alternative treatment strategy for epilepsy. Therefore, it is fundamental to understand the detailed mechanisms governing the release and action of transgene NPY in neuronal circuitries. Using whole-cell recordings from subicular neurons, we show that in animals transduced by recombinant adeno-associated viral (rAAV) vector carrying the NPY gene, transgene NPY is released during high-frequency activation of CA1-subicular synapses. Released transgene NPY attenuates excitatory synaptic transmission not only in activated, but also in neighboring, non-activated synapses. Such broad action of transgene NPY may prevent recruitment of excitatory synapses in epileptic activity and could play a key role in limiting the spread and generalization of seizures.
Originalsprog | Engelsk |
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Tidsskrift | Molecular and Cellular Neuroscience |
Vol/bind | 39 |
Udgave nummer | 2 |
Sider (fra-til) | 229-37 |
Antal sider | 9 |
ISSN | 1044-7431 |
DOI | |
Status | Udgivet - okt. 2008 |
ID: 186411872