Acculturation and celiac disease risk in second-generation immigrants: a nationwide cohort study in Sweden
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Acculturation and celiac disease risk in second-generation immigrants : a nationwide cohort study in Sweden. / Clinical Sciences, Malmö, Lund University, Department; Agardh, Daniel; Merlo, Juan.
I: Scandinavian Journal of Gastroenterology, Bind 47, Nr. 10, 10.2012, s. 1174-80.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Acculturation and celiac disease risk in second-generation immigrants
T2 - a nationwide cohort study in Sweden
AU - Clinical Sciences, Malmö, Lund University, Department
AU - Agardh, Daniel
AU - Merlo, Juan
PY - 2012/10
Y1 - 2012/10
N2 - OBJECTIVES: The burden of celiac disease (CD) is increasingly recognized as a global problem. However, whether this situation depends on genetics or environmental factors is uncertain. The authors examined these aspects in Sweden, a country in which the risk of CD is generally considered to be high. If environmental factors are relevant, CD risk in second-generation immigrant children should be related to maternal length of stay in Sweden before delivery.MATERIAL AND METHODS: Linking the Swedish Medical Birth Registry to other national registries, the authors investigated all singleton children (n = 792,401) born in Sweden between 1987 and 1993. They studied the risk of CD in children before age 6 as a function of the mother's geographical region of birth and length of stay in Sweden before delivery using Cox regression models.RESULTS: In children whose mothers immigrated to Sweden from a country outside of Europe, a maternal length of stay in Sweden of more than 5 years increased the hazard ratio (HR) of CD (1.73, 95% confidence interval (CI) 1.06-2.81). The authors observed a similar result among children born to mothers from a Nordic country outside of Sweden (HR 1.57, 95% CI 0.89-2.75), but a non-conclusive protective effect was observed in second-generation immigrant children from a non-Nordic European country (HR 0.65, 95% CI 0.39-1.09).CONCLUSIONS: The risk of CD among second-generation immigrants seems to be conditioned by maternal length of stay in Sweden before delivery, suggesting that environmental factors contribute to the variation in CD risk observed across populations.
AB - OBJECTIVES: The burden of celiac disease (CD) is increasingly recognized as a global problem. However, whether this situation depends on genetics or environmental factors is uncertain. The authors examined these aspects in Sweden, a country in which the risk of CD is generally considered to be high. If environmental factors are relevant, CD risk in second-generation immigrant children should be related to maternal length of stay in Sweden before delivery.MATERIAL AND METHODS: Linking the Swedish Medical Birth Registry to other national registries, the authors investigated all singleton children (n = 792,401) born in Sweden between 1987 and 1993. They studied the risk of CD in children before age 6 as a function of the mother's geographical region of birth and length of stay in Sweden before delivery using Cox regression models.RESULTS: In children whose mothers immigrated to Sweden from a country outside of Europe, a maternal length of stay in Sweden of more than 5 years increased the hazard ratio (HR) of CD (1.73, 95% confidence interval (CI) 1.06-2.81). The authors observed a similar result among children born to mothers from a Nordic country outside of Sweden (HR 1.57, 95% CI 0.89-2.75), but a non-conclusive protective effect was observed in second-generation immigrant children from a non-Nordic European country (HR 0.65, 95% CI 0.39-1.09).CONCLUSIONS: The risk of CD among second-generation immigrants seems to be conditioned by maternal length of stay in Sweden before delivery, suggesting that environmental factors contribute to the variation in CD risk observed across populations.
KW - Acculturation
KW - Celiac Disease/epidemiology
KW - Child
KW - Child, Preschool
KW - Cohort Effect
KW - Cohort Studies
KW - Cost of Illness
KW - Emigrants and Immigrants/statistics & numerical data
KW - Environmental Health
KW - Female
KW - Health Status Disparities
KW - Humans
KW - Incidence
KW - Male
KW - Mothers/statistics & numerical data
KW - Proportional Hazards Models
KW - Registries/statistics & numerical data
KW - Risk Assessment
KW - Risk Factors
KW - Sweden/epidemiology
KW - Time Factors
KW - Young Adult
U2 - 10.3109/00365521.2012.703238
DO - 10.3109/00365521.2012.703238
M3 - Journal article
C2 - 22827636
VL - 47
SP - 1174
EP - 1180
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 10
ER -
ID: 364855454