Absolute and Relative Risks of Hematologic Disease and Cause-Specific Death in Individuals with Incidentally Discovered Thrombocytopenia: A Prospective Study of Two Independent General Population Cohorts Including 486,782 Individuals from the United Kingdom and Denmark
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Absolute and Relative Risks of Hematologic Disease and Cause-Specific Death in Individuals with Incidentally Discovered Thrombocytopenia: A Prospective Study of Two Independent General Population Cohorts Including 486,782 Individuals from the United Kingdom and Denmark. / Juhl, Anne Rudbeck; Glenthoej, Andreas; Nordestgaard, Boerge Groenne; Petersen, Jesper; Dahl, Morten; Ellervik, Christina; Bojesen, Stig Egil; Helby, Jens.
I: Blood, Bind 142, Nr. Supplement 1, 2023, s. 395.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Absolute and Relative Risks of Hematologic Disease and Cause-Specific Death in Individuals with Incidentally Discovered Thrombocytopenia: A Prospective Study of Two Independent General Population Cohorts Including 486,782 Individuals from the United Kingdom and Denmark
AU - Juhl, Anne Rudbeck
AU - Glenthoej, Andreas
AU - Nordestgaard, Boerge Groenne
AU - Petersen, Jesper
AU - Dahl, Morten
AU - Ellervik, Christina
AU - Bojesen, Stig Egil
AU - Helby, Jens
PY - 2023
Y1 - 2023
N2 - Background:Incidentally discovered thrombocytopenia in asymptomatic individuals often result in a referral to hematology. Clinical decisions for these individuals are mostly based on local practice, as little evidence exists on their risk of hematologic disease and death. We aim to lay ground for an evidence-based clinical approach to incidental thrombocytopenia with or without concurrent anemia by studying relative and absolute risk of being diagnosed with hematologic disease, death from hematologic disease and death from any cause.Methods:We studied 382,424 general population individuals from the United Kingdom (UK) Biobank aged 40-70 years, of whom 9,151 had thrombocytopenia with or without anemia. Individuals with leukocytosis, neutropenia or prior hematologic disease were excluded. As a validation cohort, we studied 104,358 Danish general population individuals. All individuals attended a health examination and had platelets, hemoglobin, leukocyte and differential count measured at study enrolment. Individuals were followed prospectively for up to 16 years for hematologic disease and cause-specific death using national registries, covering all deaths and almost all cancer cases in the UK and Denmark.Results:Among 382,424 individuals from the UK, 6,044 had hematologic disease during follow-up, 28,403 died from any cause and 1,213 died due to hematologic disease. For all analyses, the reference group was individuals with normal platelet count and normal hemoglobin.
AB - Background:Incidentally discovered thrombocytopenia in asymptomatic individuals often result in a referral to hematology. Clinical decisions for these individuals are mostly based on local practice, as little evidence exists on their risk of hematologic disease and death. We aim to lay ground for an evidence-based clinical approach to incidental thrombocytopenia with or without concurrent anemia by studying relative and absolute risk of being diagnosed with hematologic disease, death from hematologic disease and death from any cause.Methods:We studied 382,424 general population individuals from the United Kingdom (UK) Biobank aged 40-70 years, of whom 9,151 had thrombocytopenia with or without anemia. Individuals with leukocytosis, neutropenia or prior hematologic disease were excluded. As a validation cohort, we studied 104,358 Danish general population individuals. All individuals attended a health examination and had platelets, hemoglobin, leukocyte and differential count measured at study enrolment. Individuals were followed prospectively for up to 16 years for hematologic disease and cause-specific death using national registries, covering all deaths and almost all cancer cases in the UK and Denmark.Results:Among 382,424 individuals from the UK, 6,044 had hematologic disease during follow-up, 28,403 died from any cause and 1,213 died due to hematologic disease. For all analyses, the reference group was individuals with normal platelet count and normal hemoglobin.
U2 - 10.1182/blood-2023-173792
DO - 10.1182/blood-2023-173792
M3 - Journal article
VL - 142
SP - 395
JO - Blood
JF - Blood
SN - 0006-4971
IS - Supplement 1
ER -
ID: 386601804