Absolute and Relative Psoriasis Area and Severity Indices (PASI) for Comparison of the Efficacy of Ixekizumab to Etanercept and Placebo in Patients with Moderate-to-severe Plaque Psoriasis: An Integrated Analysis of UNCOVER-2 and UNCOVER-3 Outcomes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Absolute and Relative Psoriasis Area and Severity Indices (PASI) for Comparison of the Efficacy of Ixekizumab to Etanercept and Placebo in Patients with Moderate-to-severe Plaque Psoriasis : An Integrated Analysis of UNCOVER-2 and UNCOVER-3 Outcomes. / Puig, Luis; Dossenbach, Martin; Berggren, Lovisa; Ljungberg, Anders; Zachariae, Claus.
I: Acta Dermato-Venereologica, Bind 99, Nr. 11, 2019, s. 971-977.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Absolute and Relative Psoriasis Area and Severity Indices (PASI) for Comparison of the Efficacy of Ixekizumab to Etanercept and Placebo in Patients with Moderate-to-severe Plaque Psoriasis
T2 - An Integrated Analysis of UNCOVER-2 and UNCOVER-3 Outcomes
AU - Puig, Luis
AU - Dossenbach, Martin
AU - Berggren, Lovisa
AU - Ljungberg, Anders
AU - Zachariae, Claus
PY - 2019
Y1 - 2019
N2 - Treatment goals defined by the absolute Psoriasis Area and Severity Index (PASI) scores offer certain advantages in the clinical setting. In order to investigate potential treatment targets, this study evaluated absolute PASI outcomes relative to other measures of response using data from two randomized clinical trials of patients with moderate-to-severe psoriasis treated with ixekizumab, etanercept, or placebo (n=2,567). Response was assessed throughout 12 weeks as the proportion of patients achieving absolute PASI band cut-offs who also reached established response criteria. Most PASI band ≤2 responders also achieved PASI 90 (70.1–100%), static Physician’s Global Assessment (0,1) (91.3–96.1%), Dermatology Life Quality Index (0,1) (63.0–67.7%), Patient Global Assessment of Disease Severity (0,1) (80.3–86.7%), and Itch Numeric Rating Scale improvement ≥4 (87.2–87.6%). Agreement sharply decreased for less stringent PASI criteria. These data indicate that PASI ≤2 represents significantly meaningful clinical and health-related quality of life improvements and may be a suitable treatment target for moderate-to-severe plaque psoriasis.
AB - Treatment goals defined by the absolute Psoriasis Area and Severity Index (PASI) scores offer certain advantages in the clinical setting. In order to investigate potential treatment targets, this study evaluated absolute PASI outcomes relative to other measures of response using data from two randomized clinical trials of patients with moderate-to-severe psoriasis treated with ixekizumab, etanercept, or placebo (n=2,567). Response was assessed throughout 12 weeks as the proportion of patients achieving absolute PASI band cut-offs who also reached established response criteria. Most PASI band ≤2 responders also achieved PASI 90 (70.1–100%), static Physician’s Global Assessment (0,1) (91.3–96.1%), Dermatology Life Quality Index (0,1) (63.0–67.7%), Patient Global Assessment of Disease Severity (0,1) (80.3–86.7%), and Itch Numeric Rating Scale improvement ≥4 (87.2–87.6%). Agreement sharply decreased for less stringent PASI criteria. These data indicate that PASI ≤2 represents significantly meaningful clinical and health-related quality of life improvements and may be a suitable treatment target for moderate-to-severe plaque psoriasis.
KW - Disease management
KW - Ixekizumab
KW - Psoriasis
U2 - 10.2340/00015555-3245
DO - 10.2340/00015555-3245
M3 - Journal article
C2 - 31240322
AN - SCOPUS:85073474195
VL - 99
SP - 971
EP - 977
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 11
ER -
ID: 241578978