TY - JOUR

T1 - Absolute and Relative Psoriasis Area and Severity Indices (PASI) for Comparison of the Efficacy of Ixekizumab to Etanercept and Placebo in Patients with Moderate-to-severe Plaque Psoriasis

T2 - An Integrated Analysis of UNCOVER-2 and UNCOVER-3 Outcomes

AU - Puig, Luis

AU - Dossenbach, Martin

AU - Berggren, Lovisa

AU - Ljungberg, Anders

AU - Zachariae, Claus

PY - 2019

Y1 - 2019

N2 - Treatment goals defined by the absolute Psoriasis Area and Severity Index (PASI) scores offer certain advantages in the clinical setting. In order to investigate potential treatment targets, this study evaluated absolute PASI outcomes relative to other measures of response using data from two randomized clinical trials of patients with moderate-to-severe psoriasis treated with ixekizumab, etanercept, or placebo (n=2,567). Response was assessed throughout 12 weeks as the proportion of patients achieving absolute PASI band cut-offs who also reached established response criteria. Most PASI band ≤2 responders also achieved PASI 90 (70.1–100%), static Physician’s Global Assessment (0,1) (91.3–96.1%), Dermatology Life Quality Index (0,1) (63.0–67.7%), Patient Global Assessment of Disease Severity (0,1) (80.3–86.7%), and Itch Numeric Rating Scale improvement ≥4 (87.2–87.6%). Agreement sharply decreased for less stringent PASI criteria. These data indicate that PASI ≤2 represents significantly meaningful clinical and health-related quality of life improvements and may be a suitable treatment target for moderate-to-severe plaque psoriasis.

AB - Treatment goals defined by the absolute Psoriasis Area and Severity Index (PASI) scores offer certain advantages in the clinical setting. In order to investigate potential treatment targets, this study evaluated absolute PASI outcomes relative to other measures of response using data from two randomized clinical trials of patients with moderate-to-severe psoriasis treated with ixekizumab, etanercept, or placebo (n=2,567). Response was assessed throughout 12 weeks as the proportion of patients achieving absolute PASI band cut-offs who also reached established response criteria. Most PASI band ≤2 responders also achieved PASI 90 (70.1–100%), static Physician’s Global Assessment (0,1) (91.3–96.1%), Dermatology Life Quality Index (0,1) (63.0–67.7%), Patient Global Assessment of Disease Severity (0,1) (80.3–86.7%), and Itch Numeric Rating Scale improvement ≥4 (87.2–87.6%). Agreement sharply decreased for less stringent PASI criteria. These data indicate that PASI ≤2 represents significantly meaningful clinical and health-related quality of life improvements and may be a suitable treatment target for moderate-to-severe plaque psoriasis.

KW - Disease management

KW - Ixekizumab

KW - Psoriasis

U2 - 10.2340/00015555-3245

DO - 10.2340/00015555-3245

M3 - Journal article

C2 - 31240322

AN - SCOPUS:85073474195

VL - 99

SP - 971

EP - 977

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 11

ER -