Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss
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Although many individuals are able to achieve weight loss, maintaining this loss over time is challenging. We aimed to study whether genetic predisposition to general or abdominal obesity predicts weight regain after weight loss. We examined the associations between genetic risk scores for higher BMI and higher waist-to-hip ratio adjusted for BMI (WHRadjBMI) with changes in weight and waist circumference up to 3 years after a 1-year weight loss program in participants (n = 822 women, n = 593 men) from the Look AHEAD (Action for Health in Diabe-tes) study who had lost ≥3% of their initial weight. Genetic predisposition to higher BMI or WHRadjBMI was not associated with weight regain after weight loss. How-ever, the WHRadjBMI genetic score did predict an increase in waist circumference independent of weight change. To conclude, a genetic predisposition to higher WHRadjBMI predicts an increase in abdominal obesity after weight loss, whereas genetic predisposition to higher BMI is not predictive of weight regain. These results suggest that genetic effects on abdominal obesity may be more pronounced than those on general obesity during weight regain.
Originalsprog | Engelsk |
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Tidsskrift | Diabetes |
Vol/bind | 72 |
Udgave nummer | 10 |
Sider (fra-til) | 1424-1432 |
Antal sider | 9 |
ISSN | 0012-1797 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
Acknowledgments. We thank the Look AHEAD Research Group at Year 4; research group members are listed in the Supplementary Material. Funding. M.R.C. and T.O.K. were supported by the Novo Nordisk Foundation (grant NNF18CC0034900). M.R.C. also was supported by a research grant from the Danish Diabetes Academy, which is funded by the Novo Nordisk Foundation (grant NNF17SA0031406). T.O.K. also was supported by the Novo Nordisk Foundation grants NNF20OC0063707 and NNF21SA0072102. Duality of Interest. This work was prepared while J.M.M. was employed at the University of Connecticut. No other potential conflicts of interest relevant to this article were reported.
Publisher Copyright:
© 2023 by the American Diabetes Association.
ID: 369122016