A systematic review of prophylactic antibiotics in the surgical treatment of maxillofacial fractures
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
A systematic review of prophylactic antibiotics in the surgical treatment of maxillofacial fractures. / Andreasen, Jens O; Jensen, Simon S; Schwartz, Ole; Hillerup, Yören.
I: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Bind 64, Nr. 11, 11.2006, s. 1664-8.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A systematic review of prophylactic antibiotics in the surgical treatment of maxillofacial fractures
AU - Andreasen, Jens O
AU - Jensen, Simon S
AU - Schwartz, Ole
AU - Hillerup, Yören
PY - 2006/11
Y1 - 2006/11
N2 - PURPOSE: A systematic review was performed to find evidence for prophylactic administration of antibiotics in relation to treatment of maxillofacial fractures.METHODS: Four studies were retrieved that fulfilled most of the requirements of being randomized controlled clinical trials.RESULTS: An analysis of these studies showed a 3-fold decrease in the infection rate of mandibular fractures in the antibiotic treated groups compared with the control groups. A variety of antibiotics had been used with an apparently uniform effect. A "1-shot" regimen or a 1-day treatment course had a similar or perhaps even better effect than 7 days of treatment. No infections were related to condylar, maxillary, or zygoma fractures.CONCLUSION: A 1-shot or 1-day administration of prophylactic antibiotics seem to be the best documented to reduce infections in the management of mandibular fractures not involving the condylar region.
AB - PURPOSE: A systematic review was performed to find evidence for prophylactic administration of antibiotics in relation to treatment of maxillofacial fractures.METHODS: Four studies were retrieved that fulfilled most of the requirements of being randomized controlled clinical trials.RESULTS: An analysis of these studies showed a 3-fold decrease in the infection rate of mandibular fractures in the antibiotic treated groups compared with the control groups. A variety of antibiotics had been used with an apparently uniform effect. A "1-shot" regimen or a 1-day treatment course had a similar or perhaps even better effect than 7 days of treatment. No infections were related to condylar, maxillary, or zygoma fractures.CONCLUSION: A 1-shot or 1-day administration of prophylactic antibiotics seem to be the best documented to reduce infections in the management of mandibular fractures not involving the condylar region.
KW - Antibiotic Prophylaxis/statistics & numerical data
KW - Humans
KW - Mandibular Fractures/surgery
KW - Maxillary Fractures/surgery
KW - Randomized Controlled Trials as Topic
KW - Surgical Wound Infection/prevention & control
KW - Zygomatic Fractures/surgery
U2 - 10.1016/j.joms.2006.02.032
DO - 10.1016/j.joms.2006.02.032
M3 - Review
C2 - 17052593
VL - 64
SP - 1664
EP - 1668
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
SN - 0278-2391
IS - 11
ER -
ID: 216255176