A systematic review and meta-analysis of the effects of vitamin D on inflammatory and clinical outcomes in patients with rheumatoid arthritis (RA)
Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › fagfællebedømt
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A systematic review and meta-analysis of the effects of vitamin D on inflammatory and clinical outcomes in patients with rheumatoid arthritis (RA). / Al-Saoodi, Hagir; Kolahdooz, Fariba; Andersen, Jens Rikardt; Jalili, Mahsa.
2023. Abstract fra Årsmøde 2023 i Dansk Selskab for KliniskErnæring , Copenhagen, Danmark.
Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › fagfællebedømt
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Ernæring , Copenhagen, Danmark, 12/05/2023.
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Ernæring , Copenhagen, Danmark.
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Ernæring , Copenhagen, Danmark.
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TY - ABST
T1 - A systematic review and meta-analysis of the effects of vitamin D on inflammatory and clinical outcomes in patients with rheumatoid arthritis (RA)
AU - Al-Saoodi, Hagir
AU - Kolahdooz, Fariba
AU - Andersen, Jens Rikardt
AU - Jalili, Mahsa
PY - 2023
Y1 - 2023
N2 - Background: Vitamin D deficiency is commonly in patients with rheumatoid arthritis, and a meta-analysis based on observational data showed that vitamin D supplementation reduced disease activity. Aim: To investigate whether vitamin D supplementation affects the inflammatory and clinical outcomes in patients with rheumatoid arthritis. Material and Methods: Literature was searched in the Cochrane Central Register, PubMed, MEDLINE, Embase, and Google Scholar. Cochrane guidelines were used with a random effects model. Of 464 publications, 11 studies were included (3049 patients). All with a placebo or a different dose of vitamin D as controls. Only one study used vitamin D with calcium. Results: Vitamin D supplementation did not reduce C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), disease activity score in 28 joints (DAS28), or health assessment questionnaire score (HAQ), but heterogeneity was marked. Vitamin D significantly reduced pain in VAS, DAS28–CRP, and DAS28–ESR. Subgroup analysis for vitamin D doses (>100 µg per day versus <100 µg per day) showed, that high doses had better effect on CRP than the low doses (P < 0.05). There was no dose effect on ESR and DAS28. Subgroup analysis for blinded versus open-label design showed no effect on CRP, but some effect on ESR (P = 0.08). The open-label study design had a significant effect on pain-VAS. Conclusions: There are minor effects of Vitamin D supplementation to patients with rheumatoid arthritis. In future studies, factors such as sun exposure, drug interaction, and dosage of vitamin D should be included.
AB - Background: Vitamin D deficiency is commonly in patients with rheumatoid arthritis, and a meta-analysis based on observational data showed that vitamin D supplementation reduced disease activity. Aim: To investigate whether vitamin D supplementation affects the inflammatory and clinical outcomes in patients with rheumatoid arthritis. Material and Methods: Literature was searched in the Cochrane Central Register, PubMed, MEDLINE, Embase, and Google Scholar. Cochrane guidelines were used with a random effects model. Of 464 publications, 11 studies were included (3049 patients). All with a placebo or a different dose of vitamin D as controls. Only one study used vitamin D with calcium. Results: Vitamin D supplementation did not reduce C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), disease activity score in 28 joints (DAS28), or health assessment questionnaire score (HAQ), but heterogeneity was marked. Vitamin D significantly reduced pain in VAS, DAS28–CRP, and DAS28–ESR. Subgroup analysis for vitamin D doses (>100 µg per day versus <100 µg per day) showed, that high doses had better effect on CRP than the low doses (P < 0.05). There was no dose effect on ESR and DAS28. Subgroup analysis for blinded versus open-label design showed no effect on CRP, but some effect on ESR (P = 0.08). The open-label study design had a significant effect on pain-VAS. Conclusions: There are minor effects of Vitamin D supplementation to patients with rheumatoid arthritis. In future studies, factors such as sun exposure, drug interaction, and dosage of vitamin D should be included.
M3 - Conference abstract for conference
T2 - Årsmøde 2023 i Dansk Selskab for Klinisk<br/>Ernæring
Y2 - 12 May 2023
ER -
ID: 395713693