A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura

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A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura. / Esserlind, A-L; Kirchmann, M; Hauge, A W; Le, H; Olesen, J.

I: European Journal of Neurology, Bind 19, Nr. 4, 2012, s. 603-609.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Esserlind, A-L, Kirchmann, M, Hauge, AW, Le, H & Olesen, J 2012, 'A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura', European Journal of Neurology, bind 19, nr. 4, s. 603-609. https://doi.org/10.1111/j.1468-1331.2011.03588.x

APA

Esserlind, A-L., Kirchmann, M., Hauge, A. W., Le, H., & Olesen, J. (2012). A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura. European Journal of Neurology, 19(4), 603-609. https://doi.org/10.1111/j.1468-1331.2011.03588.x

Vancouver

Esserlind A-L, Kirchmann M, Hauge AW, Le H, Olesen J. A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura. European Journal of Neurology. 2012;19(4):603-609. https://doi.org/10.1111/j.1468-1331.2011.03588.x

Author

Esserlind, A-L ; Kirchmann, M ; Hauge, A W ; Le, H ; Olesen, J. / A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura. I: European Journal of Neurology. 2012 ; Bind 19, Nr. 4. s. 603-609.

Bibtex

@article{2ea94ad823ba4642bf17d86a66d0a47a,

title = "A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura",

abstract = "Background and purpose: Although the genetics of familial hemiplegic migraine are being unraveled, this is not the case for the prevalent types of migraine. However, a recent genome wide association study (GWAS) reported an association of the single nucleotide polymorphism (SNP) rs1835740 and migraine. The aim of this study is to evaluate the association of clinical characteristics in migraine with aura (MA) with the newly discovered minor allele A of rs1835740 at 8q22.1. Methods: Participants were recruited from the Danish Headache Center and from specialist practices during the periods 1999-2002 and 2005-2006, and diagnosed according to the International Classification of Headache Disorders (ICHD-II) using a validated physician-conducted semi-structured interview. A large number of clinical characteristics were systematically determined. Caucasians of Danish ancestry diagnosed with MA and successfully genotyped for the SNP rs1835740 were included. Patients with hemiplegic migraine were excluded. Blood samples were collected for extraction of genomic DNA and genotyped for the common susceptibility variant rs1835740. Results: Six hundred and ninety one successfully genotyped MA patients with substantial description of their clinical characteristics were included. Two hundred and fifty one were heterozygous and 40 were homozygote for the variant marker. Carriers of the rs1835740 variant showed a non-significant tendency towards having a higher frequency of aura symptoms and a non-significant tendency towards milder migraine headache characteristics and fewer accompanying symptoms. These tendencies were not increased in homozygote carriers. Conclusion: None of the clinical characteristics of MA were significantly influenced by the common susceptibility variant on 8q22.1.",

author = "A-L Esserlind and M Kirchmann and Hauge, {A W} and H Le and J Olesen",

note = "{\textcopyright} 2011 The Author(s). European Journal of Neurology {\textcopyright} 2011 EFNS.",

year = "2012",

doi = "10.1111/j.1468-1331.2011.03588.x",

language = "English",

volume = "19",

pages = "603--609",

journal = "European Journal of Neurology",

issn = "1351-5101",

publisher = "Wiley-Blackwell",

number = "4",

}

RIS

TY - JOUR

T1 - A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura

AU - Esserlind, A-L

AU - Kirchmann, M

AU - Hauge, A W

AU - Le, H

AU - Olesen, J

PY - 2012

Y1 - 2012

N2 - Background and purpose: Although the genetics of familial hemiplegic migraine are being unraveled, this is not the case for the prevalent types of migraine. However, a recent genome wide association study (GWAS) reported an association of the single nucleotide polymorphism (SNP) rs1835740 and migraine. The aim of this study is to evaluate the association of clinical characteristics in migraine with aura (MA) with the newly discovered minor allele A of rs1835740 at 8q22.1. Methods: Participants were recruited from the Danish Headache Center and from specialist practices during the periods 1999-2002 and 2005-2006, and diagnosed according to the International Classification of Headache Disorders (ICHD-II) using a validated physician-conducted semi-structured interview. A large number of clinical characteristics were systematically determined. Caucasians of Danish ancestry diagnosed with MA and successfully genotyped for the SNP rs1835740 were included. Patients with hemiplegic migraine were excluded. Blood samples were collected for extraction of genomic DNA and genotyped for the common susceptibility variant rs1835740. Results: Six hundred and ninety one successfully genotyped MA patients with substantial description of their clinical characteristics were included. Two hundred and fifty one were heterozygous and 40 were homozygote for the variant marker. Carriers of the rs1835740 variant showed a non-significant tendency towards having a higher frequency of aura symptoms and a non-significant tendency towards milder migraine headache characteristics and fewer accompanying symptoms. These tendencies were not increased in homozygote carriers. Conclusion: None of the clinical characteristics of MA were significantly influenced by the common susceptibility variant on 8q22.1.

AB - Background and purpose: Although the genetics of familial hemiplegic migraine are being unraveled, this is not the case for the prevalent types of migraine. However, a recent genome wide association study (GWAS) reported an association of the single nucleotide polymorphism (SNP) rs1835740 and migraine. The aim of this study is to evaluate the association of clinical characteristics in migraine with aura (MA) with the newly discovered minor allele A of rs1835740 at 8q22.1. Methods: Participants were recruited from the Danish Headache Center and from specialist practices during the periods 1999-2002 and 2005-2006, and diagnosed according to the International Classification of Headache Disorders (ICHD-II) using a validated physician-conducted semi-structured interview. A large number of clinical characteristics were systematically determined. Caucasians of Danish ancestry diagnosed with MA and successfully genotyped for the SNP rs1835740 were included. Patients with hemiplegic migraine were excluded. Blood samples were collected for extraction of genomic DNA and genotyped for the common susceptibility variant rs1835740. Results: Six hundred and ninety one successfully genotyped MA patients with substantial description of their clinical characteristics were included. Two hundred and fifty one were heterozygous and 40 were homozygote for the variant marker. Carriers of the rs1835740 variant showed a non-significant tendency towards having a higher frequency of aura symptoms and a non-significant tendency towards milder migraine headache characteristics and fewer accompanying symptoms. These tendencies were not increased in homozygote carriers. Conclusion: None of the clinical characteristics of MA were significantly influenced by the common susceptibility variant on 8q22.1.

U2 - 10.1111/j.1468-1331.2011.03588.x

DO - 10.1111/j.1468-1331.2011.03588.x

M3 - Journal article

C2 - 22103325

VL - 19

SP - 603

EP - 609

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 4

ER -

ID: 40186657