A broken network of susceptibility genes in the monocytes of Crohn's disease patients

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A broken network of susceptibility genes in the monocytes of Crohn's disease patients. / Liu, Hankui; Guan, Liping; Su, Xi; Zhao, Lijian; Shu, Qing; Zhang, Jianguo.

I: Life Science Alliance, Bind 7, Nr. 9, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Liu, H, Guan, L, Su, X, Zhao, L, Shu, Q & Zhang, J 2024, 'A broken network of susceptibility genes in the monocytes of Crohn's disease patients', Life Science Alliance, bind 7, nr. 9. https://doi.org/10.26508/lsa.202302394

APA

Liu, H., Guan, L., Su, X., Zhao, L., Shu, Q., & Zhang, J. (2024). A broken network of susceptibility genes in the monocytes of Crohn's disease patients. Life Science Alliance, 7(9). https://doi.org/10.26508/lsa.202302394

Vancouver

Liu H, Guan L, Su X, Zhao L, Shu Q, Zhang J. A broken network of susceptibility genes in the monocytes of Crohn's disease patients. Life Science Alliance. 2024;7(9). https://doi.org/10.26508/lsa.202302394

Author

Liu, Hankui ; Guan, Liping ; Su, Xi ; Zhao, Lijian ; Shu, Qing ; Zhang, Jianguo. / A broken network of susceptibility genes in the monocytes of Crohn's disease patients. I: Life Science Alliance. 2024 ; Bind 7, Nr. 9.

Bibtex

@article{70c0a4a0945c4c5085acac4bcbf9fa56,

title = "A broken network of susceptibility genes in the monocytes of Crohn's disease patients",

abstract = "Genome-wide association studies have identified over 200 genetic loci associated with inflammatory bowel disease; however, the mechanism of such a large amount of susceptibility genes remains uncertain. In this study, we integrated bioinformatics analysis and two independent single-cell transcriptome datasets to investigate the expression network of 232 susceptibility genes in Crohn's disease (CD) patients and healthy controls. The study revealed that most of the susceptibility genes are specifically and strictly expressed in the monocytes of the human intestinal tract. The susceptibility genes established a network within the monocytes of health control. The robustness of a gene network may prevent disease onset that is influenced by the genetic and environmental alteration in the expression of susceptibility genes. In contrast, we showed a sparse network in pediatric/adult CD patients, suggesting the broken network contributed to the CD etiology. The network status of susceptibility genes at the single-cell level of monocytes provided novel insight into the etiology.",

author = "Hankui Liu and Liping Guan and Xi Su and Lijian Zhao and Qing Shu and Jianguo Zhang",

note = "Publisher Copyright: {\textcopyright} 2024 Liu et al.",

year = "2024",

doi = "10.26508/lsa.202302394",

language = "English",

volume = "7",

journal = "Life Science Alliance",

issn = "2575-1077",

publisher = "Life Science Alliance",

number = "9",

}

RIS

TY - JOUR

T1 - A broken network of susceptibility genes in the monocytes of Crohn's disease patients

AU - Liu, Hankui

AU - Guan, Liping

AU - Su, Xi

AU - Zhao, Lijian

AU - Shu, Qing

AU - Zhang, Jianguo

PY - 2024

Y1 - 2024

N2 - Genome-wide association studies have identified over 200 genetic loci associated with inflammatory bowel disease; however, the mechanism of such a large amount of susceptibility genes remains uncertain. In this study, we integrated bioinformatics analysis and two independent single-cell transcriptome datasets to investigate the expression network of 232 susceptibility genes in Crohn's disease (CD) patients and healthy controls. The study revealed that most of the susceptibility genes are specifically and strictly expressed in the monocytes of the human intestinal tract. The susceptibility genes established a network within the monocytes of health control. The robustness of a gene network may prevent disease onset that is influenced by the genetic and environmental alteration in the expression of susceptibility genes. In contrast, we showed a sparse network in pediatric/adult CD patients, suggesting the broken network contributed to the CD etiology. The network status of susceptibility genes at the single-cell level of monocytes provided novel insight into the etiology.

AB - Genome-wide association studies have identified over 200 genetic loci associated with inflammatory bowel disease; however, the mechanism of such a large amount of susceptibility genes remains uncertain. In this study, we integrated bioinformatics analysis and two independent single-cell transcriptome datasets to investigate the expression network of 232 susceptibility genes in Crohn's disease (CD) patients and healthy controls. The study revealed that most of the susceptibility genes are specifically and strictly expressed in the monocytes of the human intestinal tract. The susceptibility genes established a network within the monocytes of health control. The robustness of a gene network may prevent disease onset that is influenced by the genetic and environmental alteration in the expression of susceptibility genes. In contrast, we showed a sparse network in pediatric/adult CD patients, suggesting the broken network contributed to the CD etiology. The network status of susceptibility genes at the single-cell level of monocytes provided novel insight into the etiology.

U2 - 10.26508/lsa.202302394

DO - 10.26508/lsa.202302394

M3 - Journal article

C2 - 38925865

AN - SCOPUS:85197151653

VL - 7

JO - Life Science Alliance

JF - Life Science Alliance

SN - 2575-1077

IS - 9

ER -

ID: 397797222