17q21 gene variation is not associated with asthma in adulthood
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17q21 gene variation is not associated with asthma in adulthood. / Kreiner-Møller, E.; Strachan, D P; Linneberg, A; Husemoen, L L N; Bisgaard, H; Bønnelykke, K.
I: Allergy, Bind 70, Nr. 1, 01.2015, s. 107-14.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - 17q21 gene variation is not associated with asthma in adulthood
AU - Kreiner-Møller, E.
AU - Strachan, D P
AU - Linneberg, A
AU - Husemoen, L L N
AU - Bisgaard, H
AU - Bønnelykke, K
N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2015/1
Y1 - 2015/1
N2 - BACKGROUND: 17q21 gene variants are the strongest known genetic determinants for childhood asthma and have been reported to interact with environmental tobacco smoke exposure in childhood. It remains unclear whether individuals with 17q21 risk variants have increased risk of asthma or reduced lung function in adulthood. The aim was to examine the association between the 17q21 region and current adult asthma and lung function, and interaction with active smoking.METHODS: We investigated the single nucleotide polymorphism rs7216389 at the 17q21 locus in 3471 adults from the Health2006 cross-sectional study and in 7008 adults from The British 1958 Birth Cohort and examined the association with current asthma, spirometry measures, and related atopic traits. Analyses were performed for interaction with active smoking.RESULTS: We found no association between rs7216389[T] and asthma when meta-analyzed (OR = 1.02 [0.92-1.13], P = 0.81). The risk variant was associated with reduced FEV1 as compared to normal FEV1 (OR = 1.10 [1.01-1.12], P = 0.033) and with allergic sensitization (OR = 1.10 [1.03-1.17], P = 0.003). Individuals with rs7216389 risk variants smoked as frequently as individuals without risk variants, and there was no evidence that smoking modified the association between rs7216389 and asthma.CONCLUSION: Our study suggests that the 17q21 rs7216389 locus variant does not substantially influence asthma risk in adulthood or susceptibility to detrimental effects of active smoking. This contrasts the findings in children and suggests that this locus is associated with a childhood-specific asthma endotype.
AB - BACKGROUND: 17q21 gene variants are the strongest known genetic determinants for childhood asthma and have been reported to interact with environmental tobacco smoke exposure in childhood. It remains unclear whether individuals with 17q21 risk variants have increased risk of asthma or reduced lung function in adulthood. The aim was to examine the association between the 17q21 region and current adult asthma and lung function, and interaction with active smoking.METHODS: We investigated the single nucleotide polymorphism rs7216389 at the 17q21 locus in 3471 adults from the Health2006 cross-sectional study and in 7008 adults from The British 1958 Birth Cohort and examined the association with current asthma, spirometry measures, and related atopic traits. Analyses were performed for interaction with active smoking.RESULTS: We found no association between rs7216389[T] and asthma when meta-analyzed (OR = 1.02 [0.92-1.13], P = 0.81). The risk variant was associated with reduced FEV1 as compared to normal FEV1 (OR = 1.10 [1.01-1.12], P = 0.033) and with allergic sensitization (OR = 1.10 [1.03-1.17], P = 0.003). Individuals with rs7216389 risk variants smoked as frequently as individuals without risk variants, and there was no evidence that smoking modified the association between rs7216389 and asthma.CONCLUSION: Our study suggests that the 17q21 rs7216389 locus variant does not substantially influence asthma risk in adulthood or susceptibility to detrimental effects of active smoking. This contrasts the findings in children and suggests that this locus is associated with a childhood-specific asthma endotype.
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Aged
KW - Alleles
KW - Asthma
KW - Chromosomes, Human, Pair 17
KW - Cross-Sectional Studies
KW - Female
KW - Gene Frequency
KW - Genetic Association Studies
KW - Genetic Predisposition to Disease
KW - Genetic Variation
KW - Genotype
KW - Humans
KW - Male
KW - Middle Aged
KW - Odds Ratio
KW - Polymorphism, Single Nucleotide
KW - Quantitative Trait Loci
KW - Respiratory Function Tests
KW - Risk Factors
KW - Sex Factors
KW - Young Adult
U2 - 10.1111/all.12537
DO - 10.1111/all.12537
M3 - Journal article
C2 - 25331618
VL - 70
SP - 107
EP - 114
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 1
ER -
ID: 160051639