YKL-40 levels and atrial fibrillation in the general population
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YKL-40 levels and atrial fibrillation in the general population. / Marott, Sarah C W; Benn, Marianne; Johansen, Julia S; Jensen, Gorm B; Tybjærg-Hansen, Anne; Nordestgaard, Børge G.
In: International Journal of Cardiology, 2013.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - YKL-40 levels and atrial fibrillation in the general population
AU - Marott, Sarah C W
AU - Benn, Marianne
AU - Johansen, Julia S
AU - Jensen, Gorm B
AU - Tybjærg-Hansen, Anne
AU - Nordestgaard, Børge G
N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
PY - 2013
Y1 - 2013
N2 - BACKGROUND: Atrial fibrillation is associated with inflammation. In contrast to inflammatory markers like C-reactive protein (CRP) and fibrinogen produced in the liver, YKL-40 is produced at the site of inflammation including in the myocardium. We hypothesized that elevated plasma YKL-40 levels associate with increased risk of atrial fibrillation. METHOD AND RESULTS: We measured plasma YKL-40 in 8731 participants from the prospective Copenhagen City Heart Study including 896 individuals who developed atrial fibrillation during up to 18years of follow-up. Additionally, we measured YKL-40 in 6621 individuals from the cross-sectional Copenhagen General Population Study including 337 cases with atrial fibrillation. A YKL-40 level >95% percentile (>204μg/L) versus 95% percentile versus
AB - BACKGROUND: Atrial fibrillation is associated with inflammation. In contrast to inflammatory markers like C-reactive protein (CRP) and fibrinogen produced in the liver, YKL-40 is produced at the site of inflammation including in the myocardium. We hypothesized that elevated plasma YKL-40 levels associate with increased risk of atrial fibrillation. METHOD AND RESULTS: We measured plasma YKL-40 in 8731 participants from the prospective Copenhagen City Heart Study including 896 individuals who developed atrial fibrillation during up to 18years of follow-up. Additionally, we measured YKL-40 in 6621 individuals from the cross-sectional Copenhagen General Population Study including 337 cases with atrial fibrillation. A YKL-40 level >95% percentile (>204μg/L) versus 95% percentile versus
U2 - 10.1016/j.ijcard.2012.04.006
DO - 10.1016/j.ijcard.2012.04.006
M3 - Journal article
C2 - 22525348
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -
ID: 48475399