Vascular endothelial growth factor receptor-3 expression in mycosis fungoides

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Vascular endothelial growth factor receptor-3 expression in mycosis fungoides. / Pedersen, Ida Holst; Willerslev-Olsen, Andreas; Vetter-Kauczok, Claudia; Krejsgaard, Thorbjørn; Lauenborg, Britt; Kopp, Katharina Luise; Geisler, Carsten; Bonefeld, Charlotte M; Zhang, Qian; Wasik, Mariusz A; Dabelsteen, Sally; Andersen, Anders Woetmann; Becker, Jurgen C; Odum, Niels.

In: Leukemia and Lymphoma, 2012.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pedersen, IH, Willerslev-Olsen, A, Vetter-Kauczok, C, Krejsgaard, T, Lauenborg, B, Kopp, KL, Geisler, C, Bonefeld, CM, Zhang, Q, Wasik, MA, Dabelsteen, S, Andersen, AW, Becker, JC & Odum, N 2012, 'Vascular endothelial growth factor receptor-3 expression in mycosis fungoides', Leukemia and Lymphoma. https://doi.org/10.3109/10428194.2012.726720

APA

Pedersen, I. H., Willerslev-Olsen, A., Vetter-Kauczok, C., Krejsgaard, T., Lauenborg, B., Kopp, K. L., Geisler, C., Bonefeld, C. M., Zhang, Q., Wasik, M. A., Dabelsteen, S., Andersen, A. W., Becker, J. C., & Odum, N. (2012). Vascular endothelial growth factor receptor-3 expression in mycosis fungoides. Leukemia and Lymphoma. https://doi.org/10.3109/10428194.2012.726720

Vancouver

Pedersen IH, Willerslev-Olsen A, Vetter-Kauczok C, Krejsgaard T, Lauenborg B, Kopp KL et al. Vascular endothelial growth factor receptor-3 expression in mycosis fungoides. Leukemia and Lymphoma. 2012. https://doi.org/10.3109/10428194.2012.726720

Author

Pedersen, Ida Holst ; Willerslev-Olsen, Andreas ; Vetter-Kauczok, Claudia ; Krejsgaard, Thorbjørn ; Lauenborg, Britt ; Kopp, Katharina Luise ; Geisler, Carsten ; Bonefeld, Charlotte M ; Zhang, Qian ; Wasik, Mariusz A ; Dabelsteen, Sally ; Andersen, Anders Woetmann ; Becker, Jurgen C ; Odum, Niels. / Vascular endothelial growth factor receptor-3 expression in mycosis fungoides. In: Leukemia and Lymphoma. 2012.

Bibtex

@article{667239e41bcb4acb93b409a18405df90,
title = "Vascular endothelial growth factor receptor-3 expression in mycosis fungoides",
abstract = "Here, we have studied vascular endothelial growth factor receptor-3 (VEGFR-3) expression in mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). Immunohistochemistry revealed that in two-thirds of 34 patients, VEGFR-3 was expressed in situ by both tumor and stromal cells irrespective of the disease stage. The natural VEGFR-3 ligand, VEGF-C, partially protected malignant T-cell lines from growth inhibition by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA). Whereas the malignant T cells did not produce VEGF-C in vitro, its expression was induced during tumor formation in vivo in a xenograft mouse model of MF. In conclusion, malignant and stromal cells express high levels of VEGFR-3 in all stages of MF. Moreover, malignant T cells trigger enhanced VEGF-C expression in fibroblasts, suggesting that cross-talk between tumor and stromal cells plays a role in lymphangiogenesis and possibly disease progression.",
author = "Pedersen, {Ida Holst} and Andreas Willerslev-Olsen and Claudia Vetter-Kauczok and Thorbj{\o}rn Krejsgaard and Britt Lauenborg and Kopp, {Katharina Luise} and Carsten Geisler and Bonefeld, {Charlotte M} and Qian Zhang and Wasik, {Mariusz A} and Sally Dabelsteen and Andersen, {Anders Woetmann} and Becker, {Jurgen C} and Niels Odum",
year = "2012",
doi = "10.3109/10428194.2012.726720",
language = "English",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Taylor & Francis",

}

RIS

TY - JOUR

T1 - Vascular endothelial growth factor receptor-3 expression in mycosis fungoides

AU - Pedersen, Ida Holst

AU - Willerslev-Olsen, Andreas

AU - Vetter-Kauczok, Claudia

AU - Krejsgaard, Thorbjørn

AU - Lauenborg, Britt

AU - Kopp, Katharina Luise

AU - Geisler, Carsten

AU - Bonefeld, Charlotte M

AU - Zhang, Qian

AU - Wasik, Mariusz A

AU - Dabelsteen, Sally

AU - Andersen, Anders Woetmann

AU - Becker, Jurgen C

AU - Odum, Niels

PY - 2012

Y1 - 2012

N2 - Here, we have studied vascular endothelial growth factor receptor-3 (VEGFR-3) expression in mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). Immunohistochemistry revealed that in two-thirds of 34 patients, VEGFR-3 was expressed in situ by both tumor and stromal cells irrespective of the disease stage. The natural VEGFR-3 ligand, VEGF-C, partially protected malignant T-cell lines from growth inhibition by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA). Whereas the malignant T cells did not produce VEGF-C in vitro, its expression was induced during tumor formation in vivo in a xenograft mouse model of MF. In conclusion, malignant and stromal cells express high levels of VEGFR-3 in all stages of MF. Moreover, malignant T cells trigger enhanced VEGF-C expression in fibroblasts, suggesting that cross-talk between tumor and stromal cells plays a role in lymphangiogenesis and possibly disease progression.

AB - Here, we have studied vascular endothelial growth factor receptor-3 (VEGFR-3) expression in mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). Immunohistochemistry revealed that in two-thirds of 34 patients, VEGFR-3 was expressed in situ by both tumor and stromal cells irrespective of the disease stage. The natural VEGFR-3 ligand, VEGF-C, partially protected malignant T-cell lines from growth inhibition by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA). Whereas the malignant T cells did not produce VEGF-C in vitro, its expression was induced during tumor formation in vivo in a xenograft mouse model of MF. In conclusion, malignant and stromal cells express high levels of VEGFR-3 in all stages of MF. Moreover, malignant T cells trigger enhanced VEGF-C expression in fibroblasts, suggesting that cross-talk between tumor and stromal cells plays a role in lymphangiogenesis and possibly disease progression.

U2 - 10.3109/10428194.2012.726720

DO - 10.3109/10428194.2012.726720

M3 - Journal article

C2 - 22946664

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

ER -

ID: 43663769