Variation in postoperative non-steroidal anti-inflammatory analgesic use after colorectal surgery: a database analysis
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Variation in postoperative non-steroidal anti-inflammatory analgesic use after colorectal surgery : a database analysis. / Pommergaard, Hans-Christian; Klein, Mads; Burcharth, Jakob; Rosenberg, Jacob; Dahl, Jørgen B; Scandinavian Postoperative Pain Alliance (ScaPAlli).
In: B M C Anesthesiology, Vol. 14, 18, 2014, p. 1-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Variation in postoperative non-steroidal anti-inflammatory analgesic use after colorectal surgery
T2 - a database analysis
AU - Pommergaard, Hans-Christian
AU - Klein, Mads
AU - Burcharth, Jakob
AU - Rosenberg, Jacob
AU - Dahl, Jørgen B
AU - Scandinavian Postoperative Pain Alliance (ScaPAlli)
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Non-steroid anti-inflammatory drugs (NSAIDs) have been proposed as part of a multimodal postoperative analgesia in patients operated for colorectal cancer. However, whether these drugs are prescribed and taken by the patients have not been evaluated. The aim of this study was to quantify the postoperative use of NSAIDs in these patients.METHODS: Data from patients operated for colorectal cancer between January 1, 2006 and December 31, 2009 were collected from the Danish Colorectal Cancer Group's (DCCG) prospective database. From the electronically registered medical records, data for the use of the two NSAIDs diclofenac and ibuprofen were recorded. The data from six colorectal departments in eastern Denmark were compared.RESULTS: Of the 2,754 patients analyzed overall, 40.6% received NSAIDs as part of their analgesic treatment. The percentage of the patients receiving NSAIDs, receiving a pre-defined dosage as a minimum and receiving NSAIDs as p.r.n. medication, and the type of NSAID were significantly different both between department and within departments. The median dose of ibuprofen and diclofenac were 1200 mg (400-2,400 mg) and 100 mg (50-200 mg), respectively.CONCLUSIONS: The large variation between and within the departments points to an inconsistency in the use of multimodal post-operative pain treatments. This may be a result of insufficient evidence on procedure specific pain treatments and possibly a lack of compliance to existing guidelines. High-quality large-scale studies are warranted to form the basis for guidelines for postoperative analgesic treatment.
AB - BACKGROUND: Non-steroid anti-inflammatory drugs (NSAIDs) have been proposed as part of a multimodal postoperative analgesia in patients operated for colorectal cancer. However, whether these drugs are prescribed and taken by the patients have not been evaluated. The aim of this study was to quantify the postoperative use of NSAIDs in these patients.METHODS: Data from patients operated for colorectal cancer between January 1, 2006 and December 31, 2009 were collected from the Danish Colorectal Cancer Group's (DCCG) prospective database. From the electronically registered medical records, data for the use of the two NSAIDs diclofenac and ibuprofen were recorded. The data from six colorectal departments in eastern Denmark were compared.RESULTS: Of the 2,754 patients analyzed overall, 40.6% received NSAIDs as part of their analgesic treatment. The percentage of the patients receiving NSAIDs, receiving a pre-defined dosage as a minimum and receiving NSAIDs as p.r.n. medication, and the type of NSAID were significantly different both between department and within departments. The median dose of ibuprofen and diclofenac were 1200 mg (400-2,400 mg) and 100 mg (50-200 mg), respectively.CONCLUSIONS: The large variation between and within the departments points to an inconsistency in the use of multimodal post-operative pain treatments. This may be a result of insufficient evidence on procedure specific pain treatments and possibly a lack of compliance to existing guidelines. High-quality large-scale studies are warranted to form the basis for guidelines for postoperative analgesic treatment.
U2 - 10.1186/1471-2253-14-18
DO - 10.1186/1471-2253-14-18
M3 - Journal article
C2 - 24649938
VL - 14
SP - 1
EP - 5
JO - BMC Anesthesiology
JF - BMC Anesthesiology
SN - 1471-2253
M1 - 18
ER -
ID: 138774658