TY - JOUR

T1 - Validation of the 10/66 Dementia Research Group Diagnostic Assessment for Dementia in Arabic

T2 - A Study in Lebanon

AU - Phung, Kieu T T

AU - Chaaya, Monique

AU - Waldemar, Gunhild

AU - Atweh, Samir

AU - Asmar, Khalil

AU - Ghusn, Husam

AU - Karam, Georges

AU - Sawaya, Raja

AU - Khoury, Rose Mary

AU - Zeinaty, Ibrahim

AU - Salman, Sandrine

AU - Hammoud, Salem

AU - Radwan, Wael

AU - Bassil, Nazem

AU - Prince, Martin

N1 - © The Author(s) 2014.

PY - 2014/12

Y1 - 2014/12

N2 - OBJECTIVES: In the North Africa and Middle East region, the illiteracy rates among older people are high, posing a great challenge to cognitive assessment. Validated diagnostic instruments for dementia in Arabic are lacking, hampering the development of dementia research in the region. The study aimed at validating the Arabic version of the 10/66 Dementia Research Group (DRG) diagnostic assessment for dementia to determine whether it is suitable for case ascertainment in epidemiological research.METHODS: A total of 244 participants older than 65 years were included, 100 with normal cognition and 144 with mild to moderate dementia. Dementia was diagnosed by clinicians according to Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria. Depression was diagnosed using the Geriatric Mental State. Trained interviewers blind to the cognitive status of the participants administered the 10/66 DRG diagnostic assessment to the participants and interviewed the caregivers. The discriminatory ability of the 10/66 DRG assessment and its subcomponents were evaluated against the clinical diagnoses.RESULTS: Half of the participants had no formal education and 49% of them were depressed. The 10/66 DRG diagnostic assessment showed excellent sensitivity (92.0%), specificity (95.1%), positive predictive value (PPV, 92.9%), and low false-positive rates among controls with no formal education (8.1%) and depression (5.6%). Each subcomponent of the 10/66 DRG diagnostic assessment independently predicted dementia diagnosis. The predictive ability of the 10/66 DRG assessment was superior to that of its subcomponents.CONCLUSION: The 10/66 DRG diagnostic assessment for dementia is well suited for case ascertainment in epidemiological studies among Arabic-speaking older population with high prevalence of illiteracy.

AB - OBJECTIVES: In the North Africa and Middle East region, the illiteracy rates among older people are high, posing a great challenge to cognitive assessment. Validated diagnostic instruments for dementia in Arabic are lacking, hampering the development of dementia research in the region. The study aimed at validating the Arabic version of the 10/66 Dementia Research Group (DRG) diagnostic assessment for dementia to determine whether it is suitable for case ascertainment in epidemiological research.METHODS: A total of 244 participants older than 65 years were included, 100 with normal cognition and 144 with mild to moderate dementia. Dementia was diagnosed by clinicians according to Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria. Depression was diagnosed using the Geriatric Mental State. Trained interviewers blind to the cognitive status of the participants administered the 10/66 DRG diagnostic assessment to the participants and interviewed the caregivers. The discriminatory ability of the 10/66 DRG assessment and its subcomponents were evaluated against the clinical diagnoses.RESULTS: Half of the participants had no formal education and 49% of them were depressed. The 10/66 DRG diagnostic assessment showed excellent sensitivity (92.0%), specificity (95.1%), positive predictive value (PPV, 92.9%), and low false-positive rates among controls with no formal education (8.1%) and depression (5.6%). Each subcomponent of the 10/66 DRG diagnostic assessment independently predicted dementia diagnosis. The predictive ability of the 10/66 DRG assessment was superior to that of its subcomponents.CONCLUSION: The 10/66 DRG diagnostic assessment for dementia is well suited for case ascertainment in epidemiological studies among Arabic-speaking older population with high prevalence of illiteracy.

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Dementia

KW - Depression

KW - Diagnostic and Statistical Manual of Mental Disorders

KW - Educational Status

KW - Female

KW - Humans

KW - Language

KW - Lebanon

KW - Male

KW - Prevalence

KW - Questionnaires

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Translating

U2 - 10.1177/0891988714532019

DO - 10.1177/0891988714532019

M3 - Journal article

C2 - 24771602

VL - 27

SP - 282

EP - 290

JO - Journal of Geriatric Psychiatry and Neurology

JF - Journal of Geriatric Psychiatry and Neurology

SN - 0891-9887

IS - 4

ER -