TY - JOUR

T1 - Trauma Induced Coagulopathy

T2 - Standard coagulation tests, biomarkers of coagulopathy and endothelial damage in patients with traumatic brain injury

AU - Genét, Gustav Folmer

AU - Johansson, Per

AU - Meyer, Martin Abild Stengaard

AU - Solbeck, Sasha

AU - Sørensen, Anne Marie

AU - Larsen, Claus Falck

AU - Welling, Karen-Lise

AU - Windeløv, Nis Agerlin

AU - Rasmussen, Lars S

AU - Ostrowski, Sisse

PY - 2013

Y1 - 2013

N2 - It remains debated whether traumatic brain injury (TBI) induces a different coagulopathy compared to non-TBI. This study investigated traditional coagulation tests, biomarkers of coagulopathy and endothelial damage in trauma patients with and without TBI. Blood from 80 adult trauma patients were sampled (median of 68 min (IQR 48-88) post-injury) upon admission to our trauma centre. Plasma/serum were retrospectively analysed for biomarkers reflecting sympathoadrenal activation (adrenaline, noradrenaline), coagulation activation/inhibition and fibrinolysis (protein C, activated protein C, tissue factor pathway inhibitor, antithrombin, prothrombinfragment 1+2, thrombin/antithrombin complex, von Willebrand factor, factor XIII, d-dimer, tissue-type plasminogen activator, plasminogen activator inhibitor-1), immunology (IL6), endothelial cell/glycocalyx damage (soluble thrombomodulin, syndecan-1) and vasculogenesis (angiopoietin-1, -2). Patients were stratified according to: 1) isolated severe head/neck injuries (AIS-head/neck≥3, AIS-other3) (sTBI+other) and 3) injuries without significant head/neck injuries (AIS-head/neck 35 sec. and > 1.2, was found in 13%, 47% and 5%, respectively (p=0.000). STBI+other had significantly higher plasma levels of adrenaline, noradrenaline, annexinV, d-dimer, IL6, syndecan-1, solubel thrombomodulin, and reduced protein C and factor XIII levels (all p

AB - It remains debated whether traumatic brain injury (TBI) induces a different coagulopathy compared to non-TBI. This study investigated traditional coagulation tests, biomarkers of coagulopathy and endothelial damage in trauma patients with and without TBI. Blood from 80 adult trauma patients were sampled (median of 68 min (IQR 48-88) post-injury) upon admission to our trauma centre. Plasma/serum were retrospectively analysed for biomarkers reflecting sympathoadrenal activation (adrenaline, noradrenaline), coagulation activation/inhibition and fibrinolysis (protein C, activated protein C, tissue factor pathway inhibitor, antithrombin, prothrombinfragment 1+2, thrombin/antithrombin complex, von Willebrand factor, factor XIII, d-dimer, tissue-type plasminogen activator, plasminogen activator inhibitor-1), immunology (IL6), endothelial cell/glycocalyx damage (soluble thrombomodulin, syndecan-1) and vasculogenesis (angiopoietin-1, -2). Patients were stratified according to: 1) isolated severe head/neck injuries (AIS-head/neck≥3, AIS-other3) (sTBI+other) and 3) injuries without significant head/neck injuries (AIS-head/neck 35 sec. and > 1.2, was found in 13%, 47% and 5%, respectively (p=0.000). STBI+other had significantly higher plasma levels of adrenaline, noradrenaline, annexinV, d-dimer, IL6, syndecan-1, solubel thrombomodulin, and reduced protein C and factor XIII levels (all p

U2 - 10.1089/neu.2012.2612

DO - 10.1089/neu.2012.2612

M3 - Journal article

C2 - 23134525

VL - 30

SP - 301

EP - 306

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 4

ER -