TY - JOUR

T1 - Traditional Cardiovascular Risk Factors and Coronary Artery Calcification in Adults With Polymyositis and Dermatomyositis

T2 - A Danish Multicenter Study

AU - Diederichsen, Louise P

AU - Diederichsen, Axel C P

AU - Simonsen, Jane A

AU - Junker, Peter

AU - Søndergaard, Klaus

AU - Lundberg, Ingrid E

AU - Tvede, Niels

AU - Gerke, Oke

AU - Christensen, Anne F

AU - Dreyer, Lene

AU - Petersen, Henrik

AU - Ejstrup, Leif

AU - Kay, Susan D

AU - Jacobsen, Søren

N1 - © 2015, American College of Rheumatology.

PY - 2015/6

Y1 - 2015/6

N2 - OBJECTIVE: To determine the occurrence of traditional cardiovascular (CV) risk factors and coronary artery calcification (CAC) in adults with polymyositis (PM) or dermatomyositis (DM) compared to healthy controls and to assess the association between CV risk factors, PM/DM, and CAC score.METHODS: Traditional CV risk factors were assessed in a cross-sectional, observational study of 76 patients with PM/DM and in 48 sex- and age-matched healthy controls. CAC was quantified by means of cardiac computed tomography scan and expressed in Agatston units. The associations between CV risk factors, PM/DM, and CAC were studied by multivariate analyses.RESULTS: Thirty-three percent of the patients were obese compared to 11% of the controls (P = 0.005). Hypertension and diabetes mellitus were more frequent in patients (71% versus 42%; P = 0.002, and 13% versus 0%; P = 0.007), and patients had higher levels of triglycerides (P = 0.0009). High CAC score occurred more frequently in patients (20% versus 4%; P = 0.04). In multivariate analysis of patient factors associated with CAC were age (P = 0.02) and smoking (P = 0.02).CONCLUSION: In this study, traditional CV risk factors and severe CAC were commonly found in patients with PM/DM. However, severe CAC was not associated with PM/DM per se, but rather with age and smoking in these patients.

AB - OBJECTIVE: To determine the occurrence of traditional cardiovascular (CV) risk factors and coronary artery calcification (CAC) in adults with polymyositis (PM) or dermatomyositis (DM) compared to healthy controls and to assess the association between CV risk factors, PM/DM, and CAC score.METHODS: Traditional CV risk factors were assessed in a cross-sectional, observational study of 76 patients with PM/DM and in 48 sex- and age-matched healthy controls. CAC was quantified by means of cardiac computed tomography scan and expressed in Agatston units. The associations between CV risk factors, PM/DM, and CAC were studied by multivariate analyses.RESULTS: Thirty-three percent of the patients were obese compared to 11% of the controls (P = 0.005). Hypertension and diabetes mellitus were more frequent in patients (71% versus 42%; P = 0.002, and 13% versus 0%; P = 0.007), and patients had higher levels of triglycerides (P = 0.0009). High CAC score occurred more frequently in patients (20% versus 4%; P = 0.04). In multivariate analysis of patient factors associated with CAC were age (P = 0.02) and smoking (P = 0.02).CONCLUSION: In this study, traditional CV risk factors and severe CAC were commonly found in patients with PM/DM. However, severe CAC was not associated with PM/DM per se, but rather with age and smoking in these patients.

KW - Age Factors

KW - Aged

KW - Case-Control Studies

KW - Comorbidity

KW - Coronary Angiography

KW - Coronary Artery Disease

KW - Cross-Sectional Studies

KW - Denmark

KW - Dermatomyositis

KW - Female

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Odds Ratio

KW - Polymyositis

KW - Prevalence

KW - Prognosis

KW - Registries

KW - Risk Assessment

KW - Risk Factors

KW - Severity of Illness Index

KW - Smoking

KW - Tomography, X-Ray Computed

KW - Vascular Calcification

U2 - 10.1002/acr.22520

DO - 10.1002/acr.22520

M3 - Journal article

C2 - 25418360

VL - 67

SP - 848

EP - 854

JO - Arthritis care and research : the official journal of the Arthritis Health Professions Association

JF - Arthritis care and research : the official journal of the Arthritis Health Professions Association

SN - 0893-7524

IS - 6

ER -