Topical combination of diclofenac, calcipotriol, and difluoromethylornithine has beneficial effects comparable to 5-fluorouracil for the treatment of non-melanoma skin cancer in mice
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Topical combination of diclofenac, calcipotriol, and difluoromethylornithine has beneficial effects comparable to 5-fluorouracil for the treatment of non-melanoma skin cancer in mice. / Pommergaard, Hans-Christian; Burcharth, Jakob; Rosenberg, Jacob; Raskov, Hans.
In: Journal of Chemotherapy, Vol. 26, No. 2, 04.2014, p. 105-110.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Topical combination of diclofenac, calcipotriol, and difluoromethylornithine has beneficial effects comparable to 5-fluorouracil for the treatment of non-melanoma skin cancer in mice
AU - Pommergaard, Hans-Christian
AU - Burcharth, Jakob
AU - Rosenberg, Jacob
AU - Raskov, Hans
PY - 2014/4
Y1 - 2014/4
N2 - Non-melanoma skin cancer (NMSC) is the most common form of skin cancer. Owing to the significant adverse effects of existing treatments, alternatives are needed. The aim of this study was to evaluate the use of topically administered combination therapy and 5-flurouracil (5-FU) for the treatment of UVB induced NMSC in a mouse model. Ninety-six SKH-1 mice were randomized to one placebo group and two treatment groups (diclofenac+calcitriol+difluoromethylornithine (DFMO) and 5-FU). After UVB radiation for 20 weeks, the mice with tumours were treated topically for the following 17 weeks. Both treatments significantly reduced the number of tumours, number of mice with tumours as well as tumour area size compared with placebo. As the clinical use of 5-FU may induce more adverse effects, a combination of diclofenac+calcitriol+DFMO could be a promising alternative. Human studies are warranted to determine the beneficial effects and possible adverse effects of this new treatment.
AB - Non-melanoma skin cancer (NMSC) is the most common form of skin cancer. Owing to the significant adverse effects of existing treatments, alternatives are needed. The aim of this study was to evaluate the use of topically administered combination therapy and 5-flurouracil (5-FU) for the treatment of UVB induced NMSC in a mouse model. Ninety-six SKH-1 mice were randomized to one placebo group and two treatment groups (diclofenac+calcitriol+difluoromethylornithine (DFMO) and 5-FU). After UVB radiation for 20 weeks, the mice with tumours were treated topically for the following 17 weeks. Both treatments significantly reduced the number of tumours, number of mice with tumours as well as tumour area size compared with placebo. As the clinical use of 5-FU may induce more adverse effects, a combination of diclofenac+calcitriol+DFMO could be a promising alternative. Human studies are warranted to determine the beneficial effects and possible adverse effects of this new treatment.
KW - Administration, Topical
KW - Animals
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Calcitriol
KW - Diclofenac
KW - Eflornithine
KW - Female
KW - Fluorouracil
KW - Mice
KW - Mice, Hairless
KW - Random Allocation
KW - Skin Neoplasms
U2 - 10.1179/1973947813Y.0000000117
DO - 10.1179/1973947813Y.0000000117
M3 - Journal article
C2 - 24090798
VL - 26
SP - 105
EP - 110
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
SN - 1120-009X
IS - 2
ER -
ID: 138556220