The role of purinergic receptors in cancer-induced bone pain
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The role of purinergic receptors in cancer-induced bone pain. / Falk, Sarah; Uldall, Maria; Heegaard, Anne-Marie.
In: Journal of Osteoporosis, 2012, p. Article ID 758181.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The role of purinergic receptors in cancer-induced bone pain
AU - Falk, Sarah
AU - Uldall, Maria
AU - Heegaard, Anne-Marie
N1 - Article ID 758181
PY - 2012
Y1 - 2012
N2 - Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. The recent development of specific animal models has increased the understanding of the molecular and cellular mechanisms underlying cancer-induced bone pain including the involvement of ATP and the purinergic receptors in the progression of the pain state. In nociception, ATP acts as an extracellular messenger to transmit sensory information both at the peripheral site of tissue damage and in the spinal cord. Several of the purinergic receptors have been shown to be important for the development and maintenance of neuropathic and inflammatory pain, and studies have demonstrated the importance of both peripheral and central mechanisms. We here provide an overview of the current literature on the role of purinergic receptors in cancer-induced bone pain with emphasis on some of the difficulties related to studying this complex pain state.
AB - Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. The recent development of specific animal models has increased the understanding of the molecular and cellular mechanisms underlying cancer-induced bone pain including the involvement of ATP and the purinergic receptors in the progression of the pain state. In nociception, ATP acts as an extracellular messenger to transmit sensory information both at the peripheral site of tissue damage and in the spinal cord. Several of the purinergic receptors have been shown to be important for the development and maintenance of neuropathic and inflammatory pain, and studies have demonstrated the importance of both peripheral and central mechanisms. We here provide an overview of the current literature on the role of purinergic receptors in cancer-induced bone pain with emphasis on some of the difficulties related to studying this complex pain state.
U2 - 10.1155/2012/758181
DO - 10.1155/2012/758181
M3 - Review
SP - Article ID 758181
JO - Journal of Osteoporosis
JF - Journal of Osteoporosis
SN - 2090-8059
ER -
ID: 45847063