The association of targeted temperature management at 33 and 36 °C with outcome in patients with moderate shock on admission after out-of-hospital cardiac arrest: a post hoc analysis of the Target Temperature Management trial
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The association of targeted temperature management at 33 and 36 °C with outcome in patients with moderate shock on admission after out-of-hospital cardiac arrest : a post hoc analysis of the Target Temperature Management trial. / Annborn, Martin; Bro-Jeppesen, John; Nielsen, Niklas; Ullén, Susann; Kjaergaard, Jesper; Hassager, Christian; Wanscher, Michael; Hovdenes, Jan; Pellis, Tommaso; Pelosi, Paolo; Wise, Matt P; Cronberg, Tobias; Erlinge, David; Friberg, Hans; TTM-trial investigators.
In: Intensive Care Medicine, Vol. 40, No. 9, 09.2014, p. 1210-1219.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The association of targeted temperature management at 33 and 36 °C with outcome in patients with moderate shock on admission after out-of-hospital cardiac arrest
T2 - a post hoc analysis of the Target Temperature Management trial
AU - Annborn, Martin
AU - Bro-Jeppesen, John
AU - Nielsen, Niklas
AU - Ullén, Susann
AU - Kjaergaard, Jesper
AU - Hassager, Christian
AU - Wanscher, Michael
AU - Hovdenes, Jan
AU - Pellis, Tommaso
AU - Pelosi, Paolo
AU - Wise, Matt P
AU - Cronberg, Tobias
AU - Erlinge, David
AU - Friberg, Hans
AU - TTM-trial investigators
PY - 2014/9
Y1 - 2014/9
N2 - PURPOSE: We hypothesized that a targeted temperature of 33 °C as compared to that of 36 °C would increase survival and reduce the severity of circulatory shock in patients with shock on admission after out-of-hospital cardiac arrest (OHCA).METHODS: The recently published Target Temperature Management trial (TTM-trial) randomized 939 OHCA patients with no difference in outcome between groups and no difference in mortality at the end of the trial in a predefined subgroup of patients with shock at admission. Shock was defined as a systolic blood pressure of <90 mm Hg for >30 min or the need of supportive measures to maintain a blood pressure ≥90 mmHg and/or clinical signs of end-organ hypoperfusion. In this post hoc analysis reported here, we further analyzed the 139 patients with shock at admission; all had been randomized to receive intervention at 33 °C (TTM33; n = 71) or 36 °C (TTM36; n = 68). Primary outcome was 180-day mortality. Secondary outcomes were intensive care unit (ICU) and 30-day mortality, severity of circulatory shock assessed by mean arterial pressure, serum lactate, fluid balance and the extended Sequential Organ Failure assessment (SOFA) score.RESULTS: There was no significance difference between targeted temperature management at 33 °C or 36 °C on 180-day mortality [log-rank test, p = 0.17, hazard ratio 1.33, 95 % confidence interval (CI) 0.88-1.98] or ICU mortality (61 vs. 44 %, p = 0.06; relative risk 1.37, 95 % CI 0.99-1.91). Serum lactate and the extended cardiovascular SOFA score were higher in the TTM33 group (p < 0.01).CONCLUSIONS: We found no benefit in survival or severity of circulatory shock with targeted temperature management at 33 °C as compared to 36 °C in patients with shock on admission after OHCA.
AB - PURPOSE: We hypothesized that a targeted temperature of 33 °C as compared to that of 36 °C would increase survival and reduce the severity of circulatory shock in patients with shock on admission after out-of-hospital cardiac arrest (OHCA).METHODS: The recently published Target Temperature Management trial (TTM-trial) randomized 939 OHCA patients with no difference in outcome between groups and no difference in mortality at the end of the trial in a predefined subgroup of patients with shock at admission. Shock was defined as a systolic blood pressure of <90 mm Hg for >30 min or the need of supportive measures to maintain a blood pressure ≥90 mmHg and/or clinical signs of end-organ hypoperfusion. In this post hoc analysis reported here, we further analyzed the 139 patients with shock at admission; all had been randomized to receive intervention at 33 °C (TTM33; n = 71) or 36 °C (TTM36; n = 68). Primary outcome was 180-day mortality. Secondary outcomes were intensive care unit (ICU) and 30-day mortality, severity of circulatory shock assessed by mean arterial pressure, serum lactate, fluid balance and the extended Sequential Organ Failure assessment (SOFA) score.RESULTS: There was no significance difference between targeted temperature management at 33 °C or 36 °C on 180-day mortality [log-rank test, p = 0.17, hazard ratio 1.33, 95 % confidence interval (CI) 0.88-1.98] or ICU mortality (61 vs. 44 %, p = 0.06; relative risk 1.37, 95 % CI 0.99-1.91). Serum lactate and the extended cardiovascular SOFA score were higher in the TTM33 group (p < 0.01).CONCLUSIONS: We found no benefit in survival or severity of circulatory shock with targeted temperature management at 33 °C as compared to 36 °C in patients with shock on admission after OHCA.
KW - Aged
KW - Body Temperature
KW - Female
KW - Hospitalization
KW - Humans
KW - Hypothermia, Induced
KW - Male
KW - Middle Aged
KW - Out-of-Hospital Cardiac Arrest
KW - Severity of Illness Index
KW - Shock
U2 - 10.1007/s00134-014-3375-8
DO - 10.1007/s00134-014-3375-8
M3 - Journal article
C2 - 25001475
VL - 40
SP - 1210
EP - 1219
JO - European Journal of Intensive Care Medicine
JF - European Journal of Intensive Care Medicine
SN - 0935-1701
IS - 9
ER -
ID: 138138634