Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study
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Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1 : A randomized, sham-controlled study. / Schoenen, Jean; Jensen, Rigmor Højland; Lantéri-Minet, Michel; Láinez, Miguel Ja; Gaul, Charly; Goodman, Amy M; Caparso, Anthony; May, Arne.
In: Cephalalgia, 2013.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1
T2 - A randomized, sham-controlled study
AU - Schoenen, Jean
AU - Jensen, Rigmor Højland
AU - Lantéri-Minet, Michel
AU - Láinez, Miguel Ja
AU - Gaul, Charly
AU - Goodman, Amy M
AU - Caparso, Anthony
AU - May, Arne
PY - 2013
Y1 - 2013
N2 - BackgroundThe pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG). We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).MethodsA multicenter, multiple CH attack study of an implantable on-demand SPG neurostimulator was conducted in patients suffering from refractory CCH. Each CH attack was randomly treated with full, sub-perception, or sham stimulation. Pain relief at 15 minutes following SPG stimulation and device- or procedure-related serious adverse events (SAEs) were evaluated.FindingsThirty-two patients were enrolled and 28 completed the randomized experimental period. Pain relief was achieved in 67.1% of full stimulation-treated attacks compared to 7.4% of sham-treated and 7.3% of sub-perception-treated attacks (p
AB - BackgroundThe pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG). We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).MethodsA multicenter, multiple CH attack study of an implantable on-demand SPG neurostimulator was conducted in patients suffering from refractory CCH. Each CH attack was randomly treated with full, sub-perception, or sham stimulation. Pain relief at 15 minutes following SPG stimulation and device- or procedure-related serious adverse events (SAEs) were evaluated.FindingsThirty-two patients were enrolled and 28 completed the randomized experimental period. Pain relief was achieved in 67.1% of full stimulation-treated attacks compared to 7.4% of sham-treated and 7.3% of sub-perception-treated attacks (p
U2 - 10.1177/0333102412473667
DO - 10.1177/0333102412473667
M3 - Journal article
C2 - 23314784
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
ER -
ID: 48477853