Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention
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Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. / Lindberg, Søren; Pedersen, Sune H; Mogelvang, Rasmus; Galatius, Søren; Flyvbjerg, Allan; Jensen, Jan Skov; Bjerre, Mette.
In: American Heart Journal, Vol. 164, No. 5, 2012, p. 786-92.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention
AU - Lindberg, Søren
AU - Pedersen, Sune H
AU - Mogelvang, Rasmus
AU - Galatius, Søren
AU - Flyvbjerg, Allan
AU - Jensen, Jan Skov
AU - Bjerre, Mette
N1 - Copyright © 2012 Mosby, Inc. All rights reserved.
PY - 2012
Y1 - 2012
N2 - The complement system is an important mediator of inflammation, which plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies suggest that activation of the complement cascade resulting in the formation of soluble membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture and may be the direct cause of tissue damage related to ischemia/reperfusion injury. However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to investigate the prognostic role of sMAC in patients with ST-segment elevation myocardial infarction (STEMI).
AB - The complement system is an important mediator of inflammation, which plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies suggest that activation of the complement cascade resulting in the formation of soluble membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture and may be the direct cause of tissue damage related to ischemia/reperfusion injury. However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to investigate the prognostic role of sMAC in patients with ST-segment elevation myocardial infarction (STEMI).
U2 - 10.1016/j.ahj.2012.08.018
DO - 10.1016/j.ahj.2012.08.018
M3 - Journal article
C2 - 23137511
VL - 164
SP - 786
EP - 792
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 5
ER -
ID: 48477083