TY - JOUR

T1 - Skin pH, Atopic Dermatitis, and Filaggrin Mutations

AU - Bandier, Josefine

AU - Johansen, Jeanne Duus

AU - Petersen, Lars Jelstrup

AU - Carlsen, Berit Christina

PY - 2014/5/14

Y1 - 2014/5/14

N2 - BACKGROUND: The acidic pH of the skin plays a role in antimicrobial defense by regulating the bacterial skin flora and aspects of barrier. Filaggrin is a co-factor in maintaining a low skin pH because of its degradation into acidic amino acids. Accordingly, lack of filaggrin due to filaggrin mutations may influence skin pH.OBJECTIVE: We aimed to determine the epidermal pH in different groups stratified by filaggrin mutations and atopic dermatitis. Further, we investigated the changes in pH according to severity of mutational status among patients with dermatitis, irrespective of skin condition.METHODS: pH was measured with a multiprobe system pH probe (PH 905), and the study population was composed of 67 individuals, who had all been genotyped for 3 filaggrin mutations (R501X, 2282del4, R2447X).RESULTS: We found no clear pattern in relation to filaggrin mutation carrier status. Individuals with wild-type filaggrin displayed both the most acidic and most alkaline values independent of concomitant skin disease; however, no statistical differences between the groups were found.CONCLUSIONS: The lack of significant diversity in skin pH in relation to filaggrin mutation carrier status suggests that the effect of filaggrin mutations on skin pH is not pronounced.

AB - BACKGROUND: The acidic pH of the skin plays a role in antimicrobial defense by regulating the bacterial skin flora and aspects of barrier. Filaggrin is a co-factor in maintaining a low skin pH because of its degradation into acidic amino acids. Accordingly, lack of filaggrin due to filaggrin mutations may influence skin pH.OBJECTIVE: We aimed to determine the epidermal pH in different groups stratified by filaggrin mutations and atopic dermatitis. Further, we investigated the changes in pH according to severity of mutational status among patients with dermatitis, irrespective of skin condition.METHODS: pH was measured with a multiprobe system pH probe (PH 905), and the study population was composed of 67 individuals, who had all been genotyped for 3 filaggrin mutations (R501X, 2282del4, R2447X).RESULTS: We found no clear pattern in relation to filaggrin mutation carrier status. Individuals with wild-type filaggrin displayed both the most acidic and most alkaline values independent of concomitant skin disease; however, no statistical differences between the groups were found.CONCLUSIONS: The lack of significant diversity in skin pH in relation to filaggrin mutation carrier status suggests that the effect of filaggrin mutations on skin pH is not pronounced.

KW - Adult

KW - DNA Mutational Analysis

KW - Denmark

KW - Dermatitis, Atopic

KW - Female

KW - Genotype

KW - Hand Dermatoses

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Intermediate Filament Proteins

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Skin

KW - Skin Tests

KW - Young Adult

U2 - 10.1097/DER.0000000000000045

DO - 10.1097/DER.0000000000000045

M3 - Journal article

C2 - 24819286

VL - 25

SP - 127

EP - 129

JO - Dermatitis

JF - Dermatitis

SN - 1710-3568

IS - 3

ER -