Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels

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Standard

Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels. / Russo, R E; Hounsgaard, J.

In: Neuroscience, Vol. 61, No. 2, 01.07.1994, p. 191-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Russo, RE & Hounsgaard, J 1994, 'Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels', Neuroscience, vol. 61, no. 2, pp. 191-7.

APA

Russo, R. E., & Hounsgaard, J. (1994). Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels. Neuroscience, 61(2), 191-7.

Vancouver

Russo RE, Hounsgaard J. Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels. Neuroscience. 1994 Jul 1;61(2):191-7.

Author

Russo, R E ; Hounsgaard, J. / Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels. In: Neuroscience. 1994 ; Vol. 61, No. 2. pp. 191-7.

Bibtex

@article{5a89ecbe0f0640a1a1c4031a2190c447,
title = "Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels",
abstract = "Windup--the gradual increase of the response--of dorsal horn neurons to repeated activation of primary afferents is an elementary form of short-term plasticity that may mediate central sensitization to pain. In deep dorsal horn neurons of the turtle spinal cord in vitro we report windup of the response to repeated depolarizing current pulses as well as to repeated stimulation of the ipsilateral dorsal root. We found both forms of windup to be mediated by a depolarizing potential produced by increasing activation of postsynaptic L-type Ca2+ channels. These results suggest a central role for intrinsic postsynaptic properties in nociceptive plasticity and for L-type Ca2+ channels as a promising target for therapeutic intervention.",
keywords = "Action Potentials, Afferent Pathways, Animals, Calcium Channels, Neuronal Plasticity, Neurons, Pain, Spinal Cord, Turtles",
author = "Russo, {R E} and J Hounsgaard",
year = "1994",
month = jul,
day = "1",
language = "English",
volume = "61",
pages = "191--7",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Pergamon Press",
number = "2",

}

RIS

TY - JOUR

T1 - Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels

AU - Russo, R E

AU - Hounsgaard, J

PY - 1994/7/1

Y1 - 1994/7/1

N2 - Windup--the gradual increase of the response--of dorsal horn neurons to repeated activation of primary afferents is an elementary form of short-term plasticity that may mediate central sensitization to pain. In deep dorsal horn neurons of the turtle spinal cord in vitro we report windup of the response to repeated depolarizing current pulses as well as to repeated stimulation of the ipsilateral dorsal root. We found both forms of windup to be mediated by a depolarizing potential produced by increasing activation of postsynaptic L-type Ca2+ channels. These results suggest a central role for intrinsic postsynaptic properties in nociceptive plasticity and for L-type Ca2+ channels as a promising target for therapeutic intervention.

AB - Windup--the gradual increase of the response--of dorsal horn neurons to repeated activation of primary afferents is an elementary form of short-term plasticity that may mediate central sensitization to pain. In deep dorsal horn neurons of the turtle spinal cord in vitro we report windup of the response to repeated depolarizing current pulses as well as to repeated stimulation of the ipsilateral dorsal root. We found both forms of windup to be mediated by a depolarizing potential produced by increasing activation of postsynaptic L-type Ca2+ channels. These results suggest a central role for intrinsic postsynaptic properties in nociceptive plasticity and for L-type Ca2+ channels as a promising target for therapeutic intervention.

KW - Action Potentials

KW - Afferent Pathways

KW - Animals

KW - Calcium Channels

KW - Neuronal Plasticity

KW - Neurons

KW - Pain

KW - Spinal Cord

KW - Turtles

M3 - Journal article

C2 - 7969900

VL - 61

SP - 191

EP - 197

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 2

ER -

ID: 33729670