Safety considerations for transplanting cryopreserved ovarian tissue to restore fertility in female patients who have recovered from Ewing's sarcoma
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Safety considerations for transplanting cryopreserved ovarian tissue to restore fertility in female patients who have recovered from Ewing's sarcoma. / Sørensen, Stine D; Greve, Tine; Wielenga, Vera Timmermans; Wallace, W Hamish B; Andersen, Claus Yding.
In: Future Oncology, Vol. 10, No. 2, 02.2014, p. 277-283.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Safety considerations for transplanting cryopreserved ovarian tissue to restore fertility in female patients who have recovered from Ewing's sarcoma
AU - Sørensen, Stine D
AU - Greve, Tine
AU - Wielenga, Vera Timmermans
AU - Wallace, W Hamish B
AU - Andersen, Claus Yding
PY - 2014/2
Y1 - 2014/2
N2 - Ewing's sarcoma (EWS) is a highly malignant cancer in children, adolescents and young adults. The chemotherapy required to treat female EWS patients may cause primary ovarian insufficiency and infertility as a side effect. Cryopreservation of ovarian tissue before the start of chemotherapy can potentially preserve fertility. When the patient has been cured and primary ovarian insufficiency has developed, transplantation of frozen/thawed ovarian tissue can restore ovarian function. The tissue is usually collected before chemotherapy is initiated, and malignant cells may contaminate the stored ovarian tissue, potentially causing recrudescence of the original cancer after transplantation. The risk of EWS metastasizing to the ovary is probably low but has not been studied in great detail. This review describes the available evidence on the risk of malignant cell contamination in the ovaries of EWS patients and presents a new case of malignant cells in an ovarian biopsy from a girl with EWS.
AB - Ewing's sarcoma (EWS) is a highly malignant cancer in children, adolescents and young adults. The chemotherapy required to treat female EWS patients may cause primary ovarian insufficiency and infertility as a side effect. Cryopreservation of ovarian tissue before the start of chemotherapy can potentially preserve fertility. When the patient has been cured and primary ovarian insufficiency has developed, transplantation of frozen/thawed ovarian tissue can restore ovarian function. The tissue is usually collected before chemotherapy is initiated, and malignant cells may contaminate the stored ovarian tissue, potentially causing recrudescence of the original cancer after transplantation. The risk of EWS metastasizing to the ovary is probably low but has not been studied in great detail. This review describes the available evidence on the risk of malignant cell contamination in the ovaries of EWS patients and presents a new case of malignant cells in an ovarian biopsy from a girl with EWS.
KW - Antineoplastic Agents
KW - Cryopreservation
KW - Female
KW - Humans
KW - Infertility, Female
KW - Neoplasm Recurrence, Local
KW - Neoplasm Seeding
KW - Ovarian Neoplasms
KW - Ovary
KW - Radiotherapy
KW - Risk
KW - Sarcoma, Ewing
U2 - 10.2217/fon.13.183
DO - 10.2217/fon.13.183
M3 - Journal article
C2 - 24490613
VL - 10
SP - 277
EP - 283
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 2
ER -
ID: 138131321