Regulatory circuits controlling white versus brown adipocyte differentiation.
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Regulatory circuits controlling white versus brown adipocyte differentiation. / Hansen, Jacob B; Kristiansen, Karsten.
In: Biochemical Journal, Vol. 398, No. 2, 2006, p. 153-68.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Regulatory circuits controlling white versus brown adipocyte differentiation.
AU - Hansen, Jacob B
AU - Kristiansen, Karsten
N1 - Keywords: Adipose Tissue; Adipose Tissue, Brown; Animals; Carrier Proteins; Cell Differentiation; Gene Expression Regulation; Humans; Ion Channels; Membrane Proteins; Mitochondrial Proteins; Signal Transduction
PY - 2006
Y1 - 2006
N2 - Adipose tissue is a major endocrine organ that exerts a profound influence on whole-body homoeostasis. Two types of adipose tissue exist in mammals: WAT (white adipose tissue) and BAT (brown adipose tissue). WAT stores energy and is the largest energy reserve in mammals, whereas BAT, expressing UCP1 (uncoupling protein 1), can dissipate energy through adaptive thermogenesis. In rodents, ample evidence supports BAT as an organ counteracting obesity, whereas less is known about the presence and significance of BAT in humans. Despite the different functions of white and brown adipocytes, knowledge of factors differentially influencing the formation of white and brown fat cells is sparse. Here we summarize recent progress in the molecular understanding of white versus brown adipocyte differentiation, including novel insights into transcriptional and signal transduction pathways. Since expression of UCP1 is the hallmark of BAT and a key factor determining energy expenditure, we also review conditions associated with enhanced energy expenditure and UCP1 expression in WAT that may provide information on processes involved in brown adipocyte differentiation.
AB - Adipose tissue is a major endocrine organ that exerts a profound influence on whole-body homoeostasis. Two types of adipose tissue exist in mammals: WAT (white adipose tissue) and BAT (brown adipose tissue). WAT stores energy and is the largest energy reserve in mammals, whereas BAT, expressing UCP1 (uncoupling protein 1), can dissipate energy through adaptive thermogenesis. In rodents, ample evidence supports BAT as an organ counteracting obesity, whereas less is known about the presence and significance of BAT in humans. Despite the different functions of white and brown adipocytes, knowledge of factors differentially influencing the formation of white and brown fat cells is sparse. Here we summarize recent progress in the molecular understanding of white versus brown adipocyte differentiation, including novel insights into transcriptional and signal transduction pathways. Since expression of UCP1 is the hallmark of BAT and a key factor determining energy expenditure, we also review conditions associated with enhanced energy expenditure and UCP1 expression in WAT that may provide information on processes involved in brown adipocyte differentiation.
U2 - 10.1042/BJ20060402
DO - 10.1042/BJ20060402
M3 - Journal article
C2 - 16898874
VL - 398
SP - 153
EP - 168
JO - Biochemical Journal
JF - Biochemical Journal
SN - 0264-6021
IS - 2
ER -
ID: 8419316