Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia
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Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. / Afzal, Shoaib; Bojesen, Stig E; Nordestgaard, Børge G.
In: Alzheimer's & Dementia, Vol. 10, No. 3, 2014, p. 296-302.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia
AU - Afzal, Shoaib
AU - Bojesen, Stig E
AU - Nordestgaard, Børge G
N1 - Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.
AB - BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.
KW - Aged
KW - Alzheimer Disease
KW - Blood Chemical Analysis
KW - Dementia, Vascular
KW - Denmark
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Risk
KW - Risk Factors
KW - Vitamin D
KW - Vitamin D Deficiency
U2 - 10.1016/j.jalz.2013.05.1765
DO - 10.1016/j.jalz.2013.05.1765
M3 - Journal article
C2 - 23871764
VL - 10
SP - 296
EP - 302
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
SN - 1552-5260
IS - 3
ER -
ID: 138501393