Postexercise nutrient intake enhances leg protein balance in early postmenopausal women
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Postexercise nutrient intake enhances leg protein balance in early postmenopausal women. / Holm, Lars; Esmarck, B.; Suetta, C.; Matsumoto, K.; Doi, Tatsuya; Mizuno, M.; Miller, Benjamin F; Kjær, Michael.
In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 60, No. 9, 01.09.2005, p. 1212-1218.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Postexercise nutrient intake enhances leg protein balance in early postmenopausal women
AU - Holm, Lars
AU - Esmarck, B.
AU - Suetta, C.
AU - Matsumoto, K.
AU - Doi, Tatsuya
AU - Mizuno, M.
AU - Miller, Benjamin F
AU - Kjær, Michael
PY - 2005/9/1
Y1 - 2005/9/1
N2 - Background. We investigated the effect of nutrient administration after a session of resistance exercise on muscle protein kinetics in six healthy, early postmenopausal women, in a crossover design of random and double-blinded administration of protein and carbohydrate (PC) or placebo (NON).Methods. Fasted participants received a primed-constant infusion of L-[ring-2H5]-phenylalanine. After 90 minutes of rest, the participants performed leg-resistance exercises followed by the oral supplementation. During the following 4 hours, net protein balance (NB) and rate of disappearance and appearance of phenylalanine were calculated from arterial–venous blood samples and blood flow measurements.Results. NB was elevated (p <.001) in the PC group compared to the NON group, and NB was not different from zero in the PC group, whereas it was negative in the NON group. Net balance results were supported by kinetic data from a reduced number of participants, showing that rate of disappearance was responsible for the initial (<1 hour) effect of PC, whereas a reduced rate of appearance enhanced the NB from 1.5 to 3 hours after training in the PC group.Conclusion. In early postmenopausal women, nutrient ingestion following resistance exercise improved anabolism by enhancing NB in skeletal muscle.
AB - Background. We investigated the effect of nutrient administration after a session of resistance exercise on muscle protein kinetics in six healthy, early postmenopausal women, in a crossover design of random and double-blinded administration of protein and carbohydrate (PC) or placebo (NON).Methods. Fasted participants received a primed-constant infusion of L-[ring-2H5]-phenylalanine. After 90 minutes of rest, the participants performed leg-resistance exercises followed by the oral supplementation. During the following 4 hours, net protein balance (NB) and rate of disappearance and appearance of phenylalanine were calculated from arterial–venous blood samples and blood flow measurements.Results. NB was elevated (p <.001) in the PC group compared to the NON group, and NB was not different from zero in the PC group, whereas it was negative in the NON group. Net balance results were supported by kinetic data from a reduced number of participants, showing that rate of disappearance was responsible for the initial (<1 hour) effect of PC, whereas a reduced rate of appearance enhanced the NB from 1.5 to 3 hours after training in the PC group.Conclusion. In early postmenopausal women, nutrient ingestion following resistance exercise improved anabolism by enhancing NB in skeletal muscle.
U2 - 10.1186/2193-1801-2-109
DO - 10.1186/2193-1801-2-109
M3 - Journal article
VL - 60
SP - 1212
EP - 1218
JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
SN - 1079-5006
IS - 9
ER -
ID: 129777614