Polymorphism in interleukin-7 receptor [alpha] gene is associated with faster CD4+ T-cell recovery after initiation of combination antiretroviral therapy
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Polymorphism in interleukin-7 receptor [alpha] gene is associated with faster CD4+ T-cell recovery after initiation of combination antiretroviral therapy. / Hartling, Hans Jakob; Thørner, Lise W; Erikstrup, Christian; Harritshøj, Lene H; Kronborg, Gitte; Pedersen, Court; Larsen, Carsten S; Helleberg, Marie; Gerstoft, Jan; Obel, Niels; Ullum, Henrik; Nielsen, Susanne D.
In: AIDS (London, England), Vol. 28, No. 12, 31.07.2014, p. 1739-1748.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Polymorphism in interleukin-7 receptor [alpha] gene is associated with faster CD4+ T-cell recovery after initiation of combination antiretroviral therapy
AU - Hartling, Hans Jakob
AU - Thørner, Lise W
AU - Erikstrup, Christian
AU - Harritshøj, Lene H
AU - Kronborg, Gitte
AU - Pedersen, Court
AU - Larsen, Carsten S
AU - Helleberg, Marie
AU - Gerstoft, Jan
AU - Obel, Niels
AU - Ullum, Henrik
AU - Nielsen, Susanne D
PY - 2014/7/31
Y1 - 2014/7/31
N2 - OBJECTIVES: To investigate single-nucleotide polymorphisms (SNPs) in the gene encoding interleukin-7 receptor α (IL7RA) as predictors for CD4⁺ T-cell change after initiation of combination antiretroviral therapy (cART) in HIV-infected whites.DESIGN: SNPs in IL7RA were determined in the Danish HIV Cohort Study.METHODS: CD4⁺ T-cell changes were estimated 6 months, 1, 2, and 5 years after initiation of cART in 1683 HIV-infected virally suppressed individuals. Five SNPs in IL7RA were examined as predictors for CD4⁺ T-cell change in the first (0-6 months after initiation of cART) and second phase (>6 months after initiation of cART) of immune recovery. Univariable and multivariable analyses including age, sex, calendar period, CD4⁺ nadir, and baseline CD4⁺ T-cell count and viral load as covariates were performed.RESULTS: Individuals carrying two T-alleles in rs6897932 had faster CD4⁺ T-cell recovery compared with individuals carrying a C-allele in the first phase of immune recovery [mean CD4⁺ T-cell change, cells/μL (95% confidence interval), in TT: 177 (151-203), CT: 131 (119-143), CC: 141 (132-151), P = 0.018]. No isolated effect of rs6897932 on CD4⁺ T-cell change was found in the second phase of immune recovery; however, the initial difference in CD4⁺ T-cell recovery remained during 5 years. The effect was most pronounced in individuals above 40 years of age.CONCLUSION: T-allele homozygosity in rs6897932 is a predictor for faster CD4⁺ T-cell recovery after initiation of cART in HIV-infected whites, however, only in the first phase of immune recovery.
AB - OBJECTIVES: To investigate single-nucleotide polymorphisms (SNPs) in the gene encoding interleukin-7 receptor α (IL7RA) as predictors for CD4⁺ T-cell change after initiation of combination antiretroviral therapy (cART) in HIV-infected whites.DESIGN: SNPs in IL7RA were determined in the Danish HIV Cohort Study.METHODS: CD4⁺ T-cell changes were estimated 6 months, 1, 2, and 5 years after initiation of cART in 1683 HIV-infected virally suppressed individuals. Five SNPs in IL7RA were examined as predictors for CD4⁺ T-cell change in the first (0-6 months after initiation of cART) and second phase (>6 months after initiation of cART) of immune recovery. Univariable and multivariable analyses including age, sex, calendar period, CD4⁺ nadir, and baseline CD4⁺ T-cell count and viral load as covariates were performed.RESULTS: Individuals carrying two T-alleles in rs6897932 had faster CD4⁺ T-cell recovery compared with individuals carrying a C-allele in the first phase of immune recovery [mean CD4⁺ T-cell change, cells/μL (95% confidence interval), in TT: 177 (151-203), CT: 131 (119-143), CC: 141 (132-151), P = 0.018]. No isolated effect of rs6897932 on CD4⁺ T-cell change was found in the second phase of immune recovery; however, the initial difference in CD4⁺ T-cell recovery remained during 5 years. The effect was most pronounced in individuals above 40 years of age.CONCLUSION: T-allele homozygosity in rs6897932 is a predictor for faster CD4⁺ T-cell recovery after initiation of cART in HIV-infected whites, however, only in the first phase of immune recovery.
U2 - 10.1097/QAD.0000000000000354
DO - 10.1097/QAD.0000000000000354
M3 - Journal article
C2 - 24911352
VL - 28
SP - 1739
EP - 1748
JO - AIDS
JF - AIDS
SN - 1350-2840
IS - 12
ER -
ID: 138221293