TY - JOUR

T1 - Patch testing with a textile dye mix – a multicentre study

AU - Ryberg, Kristina

AU - Agner, Tove

AU - Andersen, Klaus E

AU - Bircher, Andreas

AU - Diepgen, Thomas

AU - Foti, Caterina

AU - Giménez-Arnau, Ana

AU - Gonçalo, Margarida

AU - Goossens, An

AU - Johansen, Jeanne D

AU - Le Coz, Christophe

AU - Maibach, Howard I

AU - Bruze, Magnus

N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Disperse dyes are well-known contact sensitizers. However, they are not included in the majority of commercially available baseline patch test series.OBJECTIVES: To investigate the outcome of patch testing with a textile dye mix (TDM) consisting of eight disperse dyes at dermatology clinics in various countries.PATIENTS/MATERIALS/METHODS: Two thousand nine hundred and seven consecutive dermatitis patients at 12 dermatology clinics representing nine countries were tested with a TDM at 6.6%, consisting of Disperse Blue 35, Disperse Yellow 3, Disperse Orange 1 and 3, and Disperse Red 1 and 17, all at 1.0%, and Disperse Blue 106 and Disperse Blue 124, each at 0.3%, provisionally included in the baseline series. Eighty-seven per cent of the patients allergic to the TDM were also tested with the eight separate dyes.RESULTS: Contact allergy to TDM was found in 108 patients (3.7%). The frequency of contact allergy varied from 2.1% to 6.9% in different centres. Simultaneous reactivity to p-phenylenediamine was found in 57 of the TDM-positive patients (53%). The most frequent dye allergen among the TDM-positive patients was Disperse Orange 3. The contact allergy could have explained or contributed to the dermatitis in approximately one-third of the patients for whom clinical relevance of the TDM contact allergy was recorded.CONCLUSIONS: The TDM should be considered for inclusion in the European baseline series.

AB - BACKGROUND: Disperse dyes are well-known contact sensitizers. However, they are not included in the majority of commercially available baseline patch test series.OBJECTIVES: To investigate the outcome of patch testing with a textile dye mix (TDM) consisting of eight disperse dyes at dermatology clinics in various countries.PATIENTS/MATERIALS/METHODS: Two thousand nine hundred and seven consecutive dermatitis patients at 12 dermatology clinics representing nine countries were tested with a TDM at 6.6%, consisting of Disperse Blue 35, Disperse Yellow 3, Disperse Orange 1 and 3, and Disperse Red 1 and 17, all at 1.0%, and Disperse Blue 106 and Disperse Blue 124, each at 0.3%, provisionally included in the baseline series. Eighty-seven per cent of the patients allergic to the TDM were also tested with the eight separate dyes.RESULTS: Contact allergy to TDM was found in 108 patients (3.7%). The frequency of contact allergy varied from 2.1% to 6.9% in different centres. Simultaneous reactivity to p-phenylenediamine was found in 57 of the TDM-positive patients (53%). The most frequent dye allergen among the TDM-positive patients was Disperse Orange 3. The contact allergy could have explained or contributed to the dermatitis in approximately one-third of the patients for whom clinical relevance of the TDM contact allergy was recorded.CONCLUSIONS: The TDM should be considered for inclusion in the European baseline series.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Azo Compounds

KW - Benzocaine

KW - Child

KW - Child, Preschool

KW - Dermatitis, Allergic Contact

KW - Humans

KW - Male

KW - Middle Aged

KW - Patch Tests

KW - Phenylenediamines

KW - Textiles

KW - Young Adult

U2 - 10.1111/cod.12244

DO - 10.1111/cod.12244

M3 - Journal article

C2 - 24815318

VL - 71

SP - 215

EP - 223

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 4

ER -