Pancreatic beta-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Pancreatic beta-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity. / Solomon, Thomas; Malin, Steven K; Karstoft, Kristian; Kashyap, Sangeeta R; Haus, Jacob M; Kirwan, John P.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 10, 21.08.2013, p. 4176-4186.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Pancreatic beta-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity
AU - Solomon, Thomas
AU - Malin, Steven K
AU - Karstoft, Kristian
AU - Kashyap, Sangeeta R
AU - Haus, Jacob M
AU - Kirwan, John P
PY - 2013/8/21
Y1 - 2013/8/21
N2 - ContextUnderstanding inter-subject variability in glycemic control following exercise training will help individualize treatment.ObjectiveTo determine whether this variability is related to training-induced changes in insulin sensitivity or pancreatic beta-cell function.Design, Setting, and ParticipantsAn observational clinical study of N=105 subjects with impaired glucose tolerance or type 2 diabetes.Interventions and Main Outcome MeasuresIndividual subject changes in fitness (VO2max), glycemia (HbA1c, fasting glucose, OGTT), insulin sensitivity (Si; hyperinsulinemic-euglycemic clamp), oral glucose-stimulated insulin secretion (GSIS), and disposition index (DI) were measured following 12-16-weeks of aerobic exercise training. Regression analyses were used to identify relationships between variables.ResultsFollowing training, 86% of subjects increased VO2max and lost weight. HbA1c, fasting glucose, and 2-hour OGTT glucose, were reduced in 69%, 62%, and 68% of subjects respectively; while Si improved in 90% of the participants. Changes in glycemic control were congruent with changes in GSIS such that 66% of subjects had a reduction in first-phase GSIS, and 46% had reduced second-phase GSIS. Training increased first- and second-phase DI in 83% and 74% of subjects. Training-induced changes in glycemic control were related to changes in GSIS (P
AB - ContextUnderstanding inter-subject variability in glycemic control following exercise training will help individualize treatment.ObjectiveTo determine whether this variability is related to training-induced changes in insulin sensitivity or pancreatic beta-cell function.Design, Setting, and ParticipantsAn observational clinical study of N=105 subjects with impaired glucose tolerance or type 2 diabetes.Interventions and Main Outcome MeasuresIndividual subject changes in fitness (VO2max), glycemia (HbA1c, fasting glucose, OGTT), insulin sensitivity (Si; hyperinsulinemic-euglycemic clamp), oral glucose-stimulated insulin secretion (GSIS), and disposition index (DI) were measured following 12-16-weeks of aerobic exercise training. Regression analyses were used to identify relationships between variables.ResultsFollowing training, 86% of subjects increased VO2max and lost weight. HbA1c, fasting glucose, and 2-hour OGTT glucose, were reduced in 69%, 62%, and 68% of subjects respectively; while Si improved in 90% of the participants. Changes in glycemic control were congruent with changes in GSIS such that 66% of subjects had a reduction in first-phase GSIS, and 46% had reduced second-phase GSIS. Training increased first- and second-phase DI in 83% and 74% of subjects. Training-induced changes in glycemic control were related to changes in GSIS (P
U2 - 10.1210/jc.2013-2232
DO - 10.1210/jc.2013-2232
M3 - Journal article
C2 - 23966244
VL - 98
SP - 4176
EP - 4186
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 10
ER -
ID: 49898695