NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease

Research output: Contribution to journal › Journal article › Research › peer-review

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NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease. / Rathcke, C.N.; Kjøller, Erik; Fogh-Andersen, N.; Zerahn, B.; Vestergaard, H.

In: P L o S One, Vol. 5, No. 12, 12.2010, p. 1-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rathcke, CN, Kjøller, E, Fogh-Andersen, N, Zerahn, B & Vestergaard, H 2010, 'NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease', P L o S One, vol. 5, no. 12, pp. 1-8. https://doi.org/10.1371/journal.pone.0014196

APA

Rathcke, C. N., Kjøller, E., Fogh-Andersen, N., Zerahn, B., & Vestergaard, H. (2010). NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease. P L o S One, 5(12), 1-8. https://doi.org/10.1371/journal.pone.0014196

Vancouver

Rathcke CN, Kjøller E, Fogh-Andersen N, Zerahn B, Vestergaard H. NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease. P L o S One. 2010 Dec;5(12):1-8. https://doi.org/10.1371/journal.pone.0014196

Author

Rathcke, C.N. ; Kjøller, Erik ; Fogh-Andersen, N. ; Zerahn, B. ; Vestergaard, H. / NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease. In: P L o S One. 2010 ; Vol. 5, No. 12. pp. 1-8.

Bibtex

@article{cf098bb768694b8e98a5fe83c543d3d6,
title = "NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease",
abstract = "Background: Myocardial perfusion imaging (MPI) can detect myocardial perfusion abnormalities but many examinations are without pathological findings. This study examines whether circulating biomarkers can be used as screening modality prior to MPI. Methodology/Principal Findings: 243 patients with an intermediate risk of CAD or with known CAD with renewed suspicion of ischemia were referred to MPI. Blood samples were analyzed for N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP), YKL-40, IL-6, matrix metalloproteinase 9 (MMP-9) and high sensitive C-reactive protein (hsCRP). Patients with myocardial perfusion defects had elevated levels of NT-proBNP (p95% regardless of existing CAD. Conclusions: 20-25% of patients suspected of CAD could have been spared a MPI by using a NT-proBNP cut-off concentration at 25 ng/l with a negative predictive value >95%. NT-proBNP has the potential use of being a screening marker of CAD before referral of the patient to MPI",
author = "C.N. Rathcke and Erik Kj{\o}ller and N. Fogh-Andersen and B. Zerahn and H. Vestergaard",
year = "2010",
month = dec,
doi = "http://dx.doi.org/10.1371/journal.pone.0014196",
language = "English",
volume = "5",
pages = "1--8",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease

AU - Rathcke, C.N.

AU - Kjøller, Erik

AU - Fogh-Andersen, N.

AU - Zerahn, B.

AU - Vestergaard, H.

PY - 2010/12

Y1 - 2010/12

N2 - Background: Myocardial perfusion imaging (MPI) can detect myocardial perfusion abnormalities but many examinations are without pathological findings. This study examines whether circulating biomarkers can be used as screening modality prior to MPI. Methodology/Principal Findings: 243 patients with an intermediate risk of CAD or with known CAD with renewed suspicion of ischemia were referred to MPI. Blood samples were analyzed for N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP), YKL-40, IL-6, matrix metalloproteinase 9 (MMP-9) and high sensitive C-reactive protein (hsCRP). Patients with myocardial perfusion defects had elevated levels of NT-proBNP (p95% regardless of existing CAD. Conclusions: 20-25% of patients suspected of CAD could have been spared a MPI by using a NT-proBNP cut-off concentration at 25 ng/l with a negative predictive value >95%. NT-proBNP has the potential use of being a screening marker of CAD before referral of the patient to MPI

AB - Background: Myocardial perfusion imaging (MPI) can detect myocardial perfusion abnormalities but many examinations are without pathological findings. This study examines whether circulating biomarkers can be used as screening modality prior to MPI. Methodology/Principal Findings: 243 patients with an intermediate risk of CAD or with known CAD with renewed suspicion of ischemia were referred to MPI. Blood samples were analyzed for N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP), YKL-40, IL-6, matrix metalloproteinase 9 (MMP-9) and high sensitive C-reactive protein (hsCRP). Patients with myocardial perfusion defects had elevated levels of NT-proBNP (p95% regardless of existing CAD. Conclusions: 20-25% of patients suspected of CAD could have been spared a MPI by using a NT-proBNP cut-off concentration at 25 ng/l with a negative predictive value >95%. NT-proBNP has the potential use of being a screening marker of CAD before referral of the patient to MPI

U2 - http://dx.doi.org/10.1371/journal.pone.0014196

DO - http://dx.doi.org/10.1371/journal.pone.0014196

M3 - Journal article

VL - 5

SP - 1

EP - 8

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 12

ER -

ID: 34097203