Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. / Kumar, Vivek; Rahbek-Clemmensen, Troels; Billesbølle, Christian B; Jorgensen, Trine Nygaard; Gether, Ulrik; Newman, Amy Hauck.

In: A C S Medicinal Chemistry Letters, Vol. 5, No. 6, 12.06.2014, p. 696-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kumar, V, Rahbek-Clemmensen, T, Billesbølle, CB, Jorgensen, TN, Gether, U & Newman, AH 2014, 'Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram', A C S Medicinal Chemistry Letters, vol. 5, no. 6, pp. 696-9. https://doi.org/10.1021/ml5000806

APA

Kumar, V., Rahbek-Clemmensen, T., Billesbølle, C. B., Jorgensen, T. N., Gether, U., & Newman, A. H. (2014). Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. A C S Medicinal Chemistry Letters, 5(6), 696-9. https://doi.org/10.1021/ml5000806

Vancouver

Kumar V, Rahbek-Clemmensen T, Billesbølle CB, Jorgensen TN, Gether U, Newman AH. Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. A C S Medicinal Chemistry Letters. 2014 Jun 12;5(6):696-9. https://doi.org/10.1021/ml5000806

Author

Kumar, Vivek ; Rahbek-Clemmensen, Troels ; Billesbølle, Christian B ; Jorgensen, Trine Nygaard ; Gether, Ulrik ; Newman, Amy Hauck. / Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. In: A C S Medicinal Chemistry Letters. 2014 ; Vol. 5, No. 6. pp. 696-9.

Bibtex

@article{d89f12d71973447c9248bb230777fcb8,
title = "Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram",
abstract = "Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hSERT, hDAT, and hNET, respectively) and for binding at SERT, in transiently transfected COS7 cells. Compound 14 demonstrated high affinity binding and selectivity for SERT (K i = 3 nM). Visualization of SERT, using confocal laser scanning microscopy, validated compound 14 as a novel tool for studying SERT expression and distribution in living cells.",
author = "Vivek Kumar and Troels Rahbek-Clemmensen and Billesb{\o}lle, {Christian B} and Jorgensen, {Trine Nygaard} and Ulrik Gether and Newman, {Amy Hauck}",
year = "2014",
month = jun,
day = "12",
doi = "10.1021/ml5000806",
language = "English",
volume = "5",
pages = "696--9",
journal = "ACS Medicinal Chemistry Letters",
issn = "1948-5875",
publisher = "American Chemical Society",
number = "6",

}

RIS

TY - JOUR

T1 - Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram

AU - Kumar, Vivek

AU - Rahbek-Clemmensen, Troels

AU - Billesbølle, Christian B

AU - Jorgensen, Trine Nygaard

AU - Gether, Ulrik

AU - Newman, Amy Hauck

PY - 2014/6/12

Y1 - 2014/6/12

N2 - Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hSERT, hDAT, and hNET, respectively) and for binding at SERT, in transiently transfected COS7 cells. Compound 14 demonstrated high affinity binding and selectivity for SERT (K i = 3 nM). Visualization of SERT, using confocal laser scanning microscopy, validated compound 14 as a novel tool for studying SERT expression and distribution in living cells.

AB - Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hSERT, hDAT, and hNET, respectively) and for binding at SERT, in transiently transfected COS7 cells. Compound 14 demonstrated high affinity binding and selectivity for SERT (K i = 3 nM). Visualization of SERT, using confocal laser scanning microscopy, validated compound 14 as a novel tool for studying SERT expression and distribution in living cells.

U2 - 10.1021/ml5000806

DO - 10.1021/ml5000806

M3 - Journal article

C2 - 24944746

VL - 5

SP - 696

EP - 699

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

SN - 1948-5875

IS - 6

ER -

ID: 120587834