Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450. / Rydberg, Patrik; Jørgensen, Martin S.; Jacobsen, T.A.; Jacobsen, A.-M.; Madsen, Kim G.; Olsen, L.

In: Angewandte Chemie International Edition, Vol. 52, No. 3, 14.01.2013, p. 993-997.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rydberg, P, Jørgensen, MS, Jacobsen, TA, Jacobsen, A-M, Madsen, KG & Olsen, L 2013, 'Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450', Angewandte Chemie International Edition, vol. 52, no. 3, pp. 993-997. https://doi.org/10.1002/anie.201206207

APA

Rydberg, P., Jørgensen, M. S., Jacobsen, T. A., Jacobsen, A-M., Madsen, K. G., & Olsen, L. (2013). Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450. Angewandte Chemie International Edition, 52(3), 993-997. https://doi.org/10.1002/anie.201206207

Vancouver

Rydberg P, Jørgensen MS, Jacobsen TA, Jacobsen A-M, Madsen KG, Olsen L. Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450. Angewandte Chemie International Edition. 2013 Jan 14;52(3):993-997. https://doi.org/10.1002/anie.201206207

Author

Rydberg, Patrik ; Jørgensen, Martin S. ; Jacobsen, T.A. ; Jacobsen, A.-M. ; Madsen, Kim G. ; Olsen, L. / Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450. In: Angewandte Chemie International Edition. 2013 ; Vol. 52, No. 3. pp. 993-997.

Bibtex

@article{ee16f1d25f024a5f8232d37ef91b7674,
title = "Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450",
abstract = "Calculations: Cytochrome P450 enzymes facilitate a number of chemically different reactions. For example, amines can be either N-dealkylated or N-oxidized, but it is complex to rationalize which of these competing reactions occurs. It is shown that the barrier for inversion of the alkylamine nitrogen atom seems to be of vital importance for the amount of N-oxidized product formed relative to dealkylation and hydroxylation products.",
author = "Patrik Rydberg and J{\o}rgensen, {Martin S.} and T.A. Jacobsen and A.-M. Jacobsen and Madsen, {Kim G.} and L. Olsen",
year = "2013",
month = jan,
day = "14",
doi = "10.1002/anie.201206207",
language = "English",
volume = "52",
pages = "993--997",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "3",

}

RIS

TY - JOUR

T1 - Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450

AU - Rydberg, Patrik

AU - Jørgensen, Martin S.

AU - Jacobsen, T.A.

AU - Jacobsen, A.-M.

AU - Madsen, Kim G.

AU - Olsen, L.

PY - 2013/1/14

Y1 - 2013/1/14

N2 - Calculations: Cytochrome P450 enzymes facilitate a number of chemically different reactions. For example, amines can be either N-dealkylated or N-oxidized, but it is complex to rationalize which of these competing reactions occurs. It is shown that the barrier for inversion of the alkylamine nitrogen atom seems to be of vital importance for the amount of N-oxidized product formed relative to dealkylation and hydroxylation products.

AB - Calculations: Cytochrome P450 enzymes facilitate a number of chemically different reactions. For example, amines can be either N-dealkylated or N-oxidized, but it is complex to rationalize which of these competing reactions occurs. It is shown that the barrier for inversion of the alkylamine nitrogen atom seems to be of vital importance for the amount of N-oxidized product formed relative to dealkylation and hydroxylation products.

UR - http://www.scopus.com/inward/record.url?scp=84872328870&partnerID=8YFLogxK

U2 - 10.1002/anie.201206207

DO - 10.1002/anie.201206207

M3 - Journal article

C2 - 23192954

AN - SCOPUS:84872328870

VL - 52

SP - 993

EP - 997

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 3

ER -

ID: 45249213