Modulation of central sensitisation by detoxification in MOH: Results of a 12-month detoxification study
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Modulation of central sensitisation by detoxification in MOH : Results of a 12-month detoxification study. / Munksgaard, Signe B; Bendtsen, Lars; Jensen, Rigmor H.
In: Cephalalgia, 2013.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Modulation of central sensitisation by detoxification in MOH
T2 - Results of a 12-month detoxification study
AU - Munksgaard, Signe B
AU - Bendtsen, Lars
AU - Jensen, Rigmor H
PY - 2013
Y1 - 2013
N2 - BackgroundHuman and animal models suggest that central sensitisation plays a role in medication-overuse headache (MOH). We aimed to study pain perception in MOH patients before and a year after withdrawal.MethodsWe examined pain perception in 35 MOH patients before and two, six and 12 months after detoxification. For baseline comparison, we tested 40 healthy controls. We measured cephalic and extra-cephalic pressure-pain thresholds and supra-threshold pressure-pain scores and extra-cephalic pain thresholds, supra-threshold pain scores and temporal summation for electrical stimulation.ResultsOf the 35 patients, 21 patients completed the entire study and remained cured of MOH. Statistically significant differences between patients and healthy controls were found in cephalic pressure-pain thresholds (137.3 kPa vs. 170 kPa, p
AB - BackgroundHuman and animal models suggest that central sensitisation plays a role in medication-overuse headache (MOH). We aimed to study pain perception in MOH patients before and a year after withdrawal.MethodsWe examined pain perception in 35 MOH patients before and two, six and 12 months after detoxification. For baseline comparison, we tested 40 healthy controls. We measured cephalic and extra-cephalic pressure-pain thresholds and supra-threshold pressure-pain scores and extra-cephalic pain thresholds, supra-threshold pain scores and temporal summation for electrical stimulation.ResultsOf the 35 patients, 21 patients completed the entire study and remained cured of MOH. Statistically significant differences between patients and healthy controls were found in cephalic pressure-pain thresholds (137.3 kPa vs. 170 kPa, p
U2 - 10.1177/0333102412475235
DO - 10.1177/0333102412475235
M3 - Journal article
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
ER -
ID: 48425371